Browsing NTNU Open by Author "Moestue, Siver Andreas"

Now showing items 21-40 of 60

    • Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Johansen, Håkon; Steen, Per Arvid; Langørgen, Sverre; Aksnessæther, Bjørg Yksnøy; Indrebø, Gunnar; Sjøbakk, Torill Eidhammer; Tessem, May-Britt; Moestue, Siver Andreas; Knobel, Heidi; Tandstad, Torgrim; Bertilsson, Helena; Solberg, Arne; Bathen, Tone Frost (Peer reviewed; Journal article, 2020)
      Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ...

    • Diffusion-weighted MRI for early detection and characterization of prostate cancer in the transgenic adenocarcinoma of the mouse prostate model 

      Hill, Deborah Katherine; Kim, Eugene; Teruel, Jose Ramon; Jamin, Yann; Widerøe, Marius; Søgaard, Caroline Danielsen; Størkersen, Øystein; Nava Rodriguez, Daniel; Heindl, Andreas; Yuan, Yinyin; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)
      Purpose To improve early diagnosis of prostate cancer to aid clinical decision-making. Diffusion-weighted magnetic resonance imaging (DW-MRI) is sensitive to water diffusion throughout tissues, which correlates with ...

    • EMT-derived alterations in glutamine metabolism sensitize mesenchymal breast cells to mTOR inhibition 

      Karvelsson, Sigurdur; Sigurdsson, Arnar; Seip, Kotryna; Grinde, Maria Tunset; Wang, Qiong; Johanssson, Freyr; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Rolfsson, Ottar; Halldórsson, Skarphédinn (Peer reviewed; Journal article, 2021)
      Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process with strong implications in cancer progression. Understanding the metabolic alterations associated with EMT may open new avenues of treatment ...

    • Estrogen receptor α promotes breast cancer by reprogramming choline metabolism 

      Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui; Zhao, Chunyan; Haldosen, Lars-Arne; Cao, Yihai; Girnita, Leonard; Moestue, Siver Andreas; Dahlman-Wright, Karin (Journal article; Peer reviewed, 2016)
      Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated ...

    • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

      Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ...

    • HR MAS NMR based metabolic profiling of colorectal tumor progression organoids 

      Malvik, Jon Olav (Master thesis, 2020)
      Kolorektal kreft er den nest dødeligste krefttypen i Norge. Dette er delvis på grunn av et asymptomatisk sykdomsforløp som ofte forårsaker at pasienter søker medisinsk hjelp sent i sykdommen. Rask diagnose, staging og ...

    • HVORDAN DISTRIBUERER APOTEKANSATTE TIDEN SIN? - En kartlegging av ansattes tidsbruk i publikumsavdelingen ved Sykehusapoteket i Bodø. 

      Østbø, Ann Katrin (Master thesis, 2019)
      Bakgrunn Feil bruk av legemidler er et økende problem i Norge noe som har ført til at regjeringen har satt søkelys på apotekene og hvordan kompetansen hos apotekansatte kan brukes for å sikre riktig bruk av legemidler. ...

    • Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS 

      Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K (Journal article; Peer reviewed, 2015)
      Tumors develop an abnormal microenvironment during growth, and similar to the metastatic phenotype, the metabolic phenotype of cancer cells is tightly linked to characteristics of the tumor microenvironment (TME). In this ...

    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016-01-28)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...

    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...

    • In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts 

      Esmaeili, Morteza; Moestue, Siver Andreas; Hamans, Bob C.; Veltien, Andor; Kristian, Alexandr; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Bathen, Tone; Heerschap, Arend (Journal article; Peer reviewed, 2015)
      Purpose To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor response to anticancer therapy. We explored 3D 31P magnetic ...

    • Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells 

      Barkovskaya, Anna; Seip, Kotryna; Prasmickaite, Lina; Mills, Ian Geoffrey; Moestue, Siver Andreas; Itkonen, Harri (Peer reviewed; Journal article, 2020)
      In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen ...

    • Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism 

      Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey (Journal article; Peer reviewed, 2016)
      Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...

    • Innføring av multidose i e-resept, og utfordringer når tre legemiddellister blir til en. 

      Sothinathan, Sukumarie (Master thesis, 2020)
      Uoverensstemmelser mellom legemiddellistene fra fastlegen, apotek og hjemmetjeneste har vært et hyppig forekommende problem. Siden alle tre aktørene tar vurderinger basert på egen legemiddelliste risikerer man at behandling ...

    • Interplay of choline metabolites and genes in patient-derived breast cancer xenografts 

      Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2014)
      Introduction Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large ...

    • Intravascular Targets for Molecular Contrast-Enhanced Ultrasound Imaging 

      Moestue, Siver Andreas; Gribbestad, Ingrid S; Hansen, Rune (Journal article; Peer reviewed, 2012)
      Molecular targeting of contrast agents for ultrasound imaging is emerging as a new medical imaging modality. It combines advances in ultrasound technology with principles of molecular imaging, thereby allowing non-invasive ...

    • Koronavaksinering i apotek: En kvalitativ studie av farmasøyters erfaringer 

      Aarnes, Ragnhild Vold (Master thesis, 2022)
      Sammendrag Bakgrunn: Under koronapandemien opplevde mange av landets kommuner at det var vanskelig å skaffe nok personale, til alle de oppgavene som måtte gjennomføres. For å øke kapasiteten til å vaksinere mot covid-19, ...

    • Legers erfaringer og vurderinger om hvordan kommunikasjon påvirker pasienters etterlevelse av legemiddelbruk 

      Bjørknes, Marthe Rambøl (Master thesis, 2019)
      Bakgrunn: Feilbruk av legemidler kan gi unødvendige bivirkninger, nedsatt livskvalitet og dødsfall. WHO rapporterte at 30-50 % av legemidler brukt ved kroniske sykdommer ikke tas som anbefalt. Å ha flere forskrivere har ...

    • Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy 

      Moestue, Siver Andreas; Engebråten, Olav; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2011)
      Despite huge efforts in development of drugs targeting oncogenic signalling, the number of such drugs entering clinical practice to date remains limited. Rational use of biomarkers for drug candidate selection and early ...

    • Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts 

      van der Kemp, Wybe J. M.; Grinde, Maria Tunset; Malvik, Jon Olav; van Laarhoven, Hanneke W. M.; Prompers, Jeanine J.; Klomp, Dennis W. J.; Burgering, Boudewijn; Bathen, Tone Frost; Moestue, Siver Andreas (Peer reviewed; Journal article, 2022)
      Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ...