Browsing NTNU Open by Author "Lægreid, Astrid"
Now showing items 21-35 of 35
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NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
Selvik, Linn-Karina M.; Rao, Shalini; Steigedal, Tonje; Haltbakk, Ildri; Misund, Kristine; Bruland, Torunn; Prestvik, Wenche S; Lægreid, Astrid; Thommesen, Liv (Journal article; Peer reviewed, 2014)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
Selvik, Linn-Karina M.; Rao, Shalini; Steigedal, Tonje; Haltbakk, Ildri; Misund, Kristine; Bruland, Torunn; Prestvik, Wenche S; Lægreid, Astrid; Thommesen, Liv (Journal article; Peer reviewed, 2014-11-10)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Scientific knowledge in the age of computation: Explicated, computable and manageable?
Efstathiou, Sophia; Nydal, Rune; Lægreid, Astrid; Kuiper, Martin (Journal article; Peer reviewed, 2019)With increasing publication and data production, scientific knowledge stands not simply as an achievement but also as a challenge. Scientific publications and data are increasingly treated as resources that need to be ... -
Signaling Pathway Modules: network organization elements for understanding cancer and designing therapies.
Tsirvouli, Eirini (Master thesis, 2019)Cancer is a heterogeneous, complex disease and one of the leading causes of death worldwide. The high heterogeneity between individuals, even those affected by the same cancer type, can lead to distinct molecular and ... -
Strategies to Enhance Logic Modeling-Based Cell Line-Specific Drug Synergy Prediction
Niederdorfer, Barbara; Touré, Vasundra; Vazques, Miguel; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid; Flobak, Åsmund (Journal article; Peer reviewed, 2020)Discrete dynamical modeling shows promise in prioritizing drug combinations for screening efforts by reducing the experimental workload inherent to the vast numbers of possible drug combinations. We have investigated ... -
A Study of Models for Prediction of Treatment Response in Cancer
Folkesson, Evelina (Doctoral theses at NTNU;2021:412, Doctoral thesis, 2021)Abstract in Norwegian Kreft kjennetegnes av molekylære forandringer som resulterer i unormal og høy celledeling. Opp gjennom årene har et vesentlig antall kjemoterapier rettet mot å hemme denne celledelingen blitt godkjent ... -
Systems Medicine: From Modeling Systems Perturbations to Predicting Drug Synergies
Flobakk, Åsmund (Doctoral thesis at NTNU;2016:55, Doctoral thesis, 2016)Computational approaches to systems biology and systems medicine enable the study of systems properties that emerge from integrating knowledge about complex interactions, such as in the study of cancer cell phenotypes ... -
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis
Selvik, Linn-Karina M.; Fjeldbo, Christina Sæten; Flatberg, Arnar; Steigedal, Tonje; Misund, Kristine; Anderssen, Endre; Doseth, Berit; Langaas, Mette; Tripathi, Sushil; Beisvag, Vidar; Lægreid, Astrid; Thommesen, Liv; Bruland, Torunn (Journal article; Peer reviewed, 2013)Background How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, ... -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Tripathi, Sushil; Flobak, Åsmund; Chawla, Konika; Baudot, Anaïs; Bruland, Torunn; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid (Journal article; Peer reviewed, 2015) -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Tripathi, Sushil; Flobak, Åsmund; Chawla, Konika; Baudot, Anaïs; Bruland, Torunn; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid (Journal article; Peer reviewed, 2015)Background: The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid ... -
The Gene Ontology Resource: 20 years and still GOing strong.
The Gene Ontology, Consortium; that, includes; Acencio, Marcio Luis; Lægreid, Astrid; Kuiper, Martin; among, others (Journal article; Peer reviewed, 2019)The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and ... -
The MIntAct project - IntAct as a common curation platform for 11 molecular interaction databases
Orchard, Sandra; Ammari, M; Aranda, B; Breuza, L; Briganti, L; Broackes-Carter, F; Campbell, NH; Chavali, G; Chen, C; Del-Toro, N; Duesbury, M; Dumousseau, M; Galeota, E; Hinz, U; Iannuccelli, M; Jagannathan, S; Jimenez, R.; Khadake, J; Lægreid, Astrid; Licata, L; Lovering, RC; Meldal, B; Melidoni, AN; Milagros, M; Peluso, D; Perfetto, Livia; Porras, P; Raghunath, A; Ricard-Blum, S; Roechert, B; Stutz, A; Tognolli, M; Van Roey, K; Cesareni, G; Hermjakob, H (Journal article; Peer reviewed, 2014)IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed ...