Blar i NTNU Open på forfatter "Damås, Jan Kristian"
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Early identification and risk factors for sepsis-clinical and epidemiological studies
Askim, Åsa Susanne (Doctoral theses at NTNU;2018:161, Doctoral thesis, 2018)Denne avhandlingen fokuserer på risikofaktorer for sepsis; angst og depresjon, alder, kjønn, komorbiditet og livsstil, og vurderer ulike verktøy for tidlig identifisering av pasienter med sepsis. Sepsis rammer 30 millioner ... -
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival
Torsvik, Malvin; Gustad, Lise; Mehl, Arne; Bangstad, Inger Lise; Vinje, Liv Jorun; Damås, Jan Kristian; Solligård, Erik (Journal article; Peer reviewed, 2016)Background: Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less ... -
Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar; Holte, Espen; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Espevik, Terje; Aakhus, Svend; Damås, Jan Kristian; Aukrust, Pål; Wiseth, Rune; Gullestad, Lars (Journal article; Peer reviewed, 2016)Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial ... -
The Effects of Shift Work on the Immune System: A Narrative Review
Thorkildsen, Marianne Thorkildsen; Gustad, Lise Tuset; Damås, Jan Kristian (Peer reviewed; Journal article, 2023)Working a shift work schedule has been hypothesized to have negative effects on health. One such described consequence is altered immune response and increased risk of infections. Former reviews have concluded that more ... -
Enhanced expression of CXCL10 in inflammatory bowel disease: Potential role of mucosal toll-like 3 receptor stimulation
Østvik, Ann Elisabet; Granlund, Atle; Bugge, Marit; Nilsen, Nadra; Torp, Sverre Helge; Waldum, Helge; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article, 2013)We explored the gene expression in colonic biopsies of active and inactive inflammatory bowel disease (IBD), in an extensive material of ulcerative colitis (UC) and Crohn`s disease (CD). The chemokine CXCL10 and its receptor ... -
Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway
Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2021) -
Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993-2011: an observational study
Askim, Åsa Susanne; Mehl, Arne; Paulsen, Julie; DeWan, Andrew T.; VESTRHEIM, DIDRIK FRIMANN; Åsvold, Bjørn Olav; Damås, Jan Kristian; Solligård, Erik (Journal article; Peer reviewed, 2016)Background: Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. ... -
Epidemiology and outcome of Staphylococcus aureusbloodstream infection and sepsis in a Norwegian county 1996–2011: an observational study
Paulsen, Julie; Mehl, Arne; Askim, Åsa Susanne; Solligård, Erik; Åsvold, Bjørn Olav; Damås, Jan Kristian (Journal article; Peer reviewed, 2015)Background: Staphylococcus aureus is one of the most common and lethal causes of bloodstream infection and the incidence is increasing. We carried out a prospective observational study of patients with Staphylococcus ... -
Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
Mohus, Randi Marie; Gustad, Lise Tuset; Furberg, Anne-Sofie; Moen, Martine Kjølberg; Liyanarachi, Kristin Vardheim; Askim, Åsa Susanne; Åsberg, Signe Elisabeth; DeWan, Andrew T.; Rogne, Tormod; Simonsen, Gunnar Skov; Nilsen, Tom Ivar Lund; Åsvold, Bjørn Olav; Damås, Jan Kristian; Solligård, Erik (Peer reviewed; Journal article, 2022)Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using ... -
Exploring the role of TLR8 as a sensor in bacterial infections
Ehrnström, Birgitta (Doctoral theses at NTNU;2019:382, Doctoral thesis, 2019) -
Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Bruland, Torunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2015)Background: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are ... -
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Torp, Sverre Helge; Flatberg, Arnar; Beisvag, Vidar; Waldum, Helge; Flo, Trude Helen; Espevik, Terje; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Anti-microbial peptides might influence the pathogenesis and course of inflammatory bowel disease (IBD). We sought to clarify the role of the anti-microbial glycoprotein lipocalin 2 (LCN2) in the colon by determining its ... -
Fatty Acids Composition and HIV Infection: Altered Levels of n-6 Polyunsaturated Fatty Acids Are Associated with Disease Progression
Ueland, Thor; Waagsbø, Bjørn; Berge, Rolf Kristian; Trøseid, Marius; Aukrust, Pål; Damås, Jan Kristian (Peer reviewed; Journal article, 2023)Fatty acids (FAs) are important regulators of immune responses and innate defense mechanisms. We hypothesized that disturbed FA metabolism could contribute to the progression of HIV infection. Plasma levels of 45 FAs were ... -
Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease
Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2017)Background and Aim Accurate, noninvasive biomarkers are needed to diagnose and monitor inflammatory bowel disease (IBD). Neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin 2, is expressed in inflamed ... -
Gestational age at birth and hospitalisations for infections among individuals aged 0–50 years in Norway: a longitudinal, register-based, cohort study
Nilsen, Sara Marie; Valand, Jonas; Rogne, Tormod; Asheim, Andreas; Yin, Weiyao; Metsälä, Johanna; Opdahl, Signe; Døllner, Henrik; Damås, Jan Kristian; Kajantie, Eero; Solligård, Erik; Sandin, Sven; Risnes, Kari Ravndal (Peer reviewed; Journal article, 2023)Background Preterm birth is associated with increased risk of childhood infections. Whether this risk persists into adulthood is unknown and limited information is available on risk patterns across the full range of ... -
High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting
Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ... -
Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling
Moen, Siv Helen; Ehrnström, Birgitta; Kojen, June Frengen; Yurchenko, Mariya; Beckwith, Kai Sandvold; Afset, Jan Egil; Damås, Jan Kristian; Zhenyi, Hu; Hang, Yin; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2019)TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived ... -
IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction
Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their ... -
Immunoregulatory roles of chemokines and epithelium in inflammatory bowel disease - CCL20 in mucosa, human colonoids and peripheral blood mononuclear cells
Skovdahl, Helene Kolstad (Doctoral theses at NTNU;2020:382, Doctoral thesis, 2020)Inflammatory bowel diseases (IBD) are characterized by chronic inflammation in the intestinal tract, which leads to substantial cost for the individual and for society. The pathogenesis is described as an inflammation ... -
Incidence, case fatality and long-term outcomes in patients with sepsis - Nationwide registry studies of sepsis and COVID-19-related sepsis
Skei, Nina Vibeche (Doctoral theses at NTNU;2024:36, Doctoral thesis, 2024)Sepsis is a severe immune reaction to an infection that leads to acute organ dysfunction and is a common cause of hospitalization, morbidity, and death. After surviving sepsis, many patients experience health impairments ...