Blar i NTNU Open på forfatter "Bruheim, Per"
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Characterization of a Paxx Knockout Mouse Model - Growth and immune system development in mice deficient of DNA repair factor PAXX
Sæterstad, Siri (Master thesis, 2018)Non-Homologous End-Joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in higher eukaryotes, functional throughout the cell cycle. NHEJ involves a variety of proteins; some are essential, whereas others ... -
Characterization of airborne bacteria at an underground subway station
Dybwad, Marius; Granum, Per Einar; Bruheim, Per; Blatny, Janet Martha (Journal article; Peer reviewed, 2012)The reliable detection of airborne biological threat agents depends on several factors, including the performance criteria of the detector and its operational environment. One step in improving the detector's performance ... -
Characterization of genotype and beer fermentation properties of Norwegian Farmhouse Ale Yeasts
Rasmussen, Truls C. (Master thesis, 2016)Eight different Norwegian Farmhouse Ale Yeasts from Voss, Stranda, Lærdal, Hornindal and Olden were donated to IBT for analysis. The yeast were phenotypically characterized and two beer styles were produced under laboratory ... -
Combined Metabolome and Lipidome analyses for in-depth characterization of lipid accumulation in the DHA producing Aurantiochytrium sp. T66
Bartosova, Zdenka; Ertesvåg, Helga; Nyfløt, Eirin Lishaugen; Kämpe, Kristoffer; Aasen, Inga Marie; Bruheim, Per (Peer reviewed; Journal article, 2021)Thraustochytrids are marine heterotrophic microorganisms known for their potential to accumulate docosahexaenoic acid (DHA)-enriched lipids. There have been many attempts to improve thraustochytrid DHA bioprocesses, ... -
Decoding the Metabolic Reprogramming Underlying Toll-like Receptor Signaling
Kim, Hera (Doctoral theses at NTNU;2021:297, Doctoral thesis, 2021) -
Demyelinating polyneuropathy in goats lacking prion protein
Skedsmo, Fredrik Strebel; Malachin, Giulia; Våge, Dag Inge; Hammervold, Mie Marie; Salvesen, Øyvind; Ersdal, Cecilie; Ranheim, Birgit; Stafsnes, Marit Hallvardsdotter; Bartosova, Zdenka; Bruheim, Per; Jäderlund, Karin Hultin; Matiasek, Kaspar; Espenes, Arild; Tranulis, Michael A. (Journal article; Peer reviewed, 2019)Studies in mice with ablation of Prnp, the gene that encodes the cellular prion protein (PrPC), have led to the hypothesis that PrPC is important for peripheral nerve myelin maintenance. Here, we have used a nontransgenic ... -
Determining the Potential of Second Generation β-clamp Targeting Peptides as Antimicrobial Agents
Husdal, Lisa (Master thesis, 2024)Antibiotikareistens er et kritisk globalt helseproblem som truer effekten av antibiotika, som har vært viktige i behandlingen av bakterielle infeksjoner siden antibiotika ble oppdaget på begynnelsen av 1900-tallet. Det ... -
Development and application of cultivation and analytical workflows for the study of cellular responses to antibiotics in E. coli
Thorfinnsdottir, Lilja Brekke (Doctoral theses at NTNU;2024:127, Doctoral thesis, 2024)Antibiotics revolutionized medicine during the 1900s. However, a void in new discoveries in the last decades and increased antibiotic resistance are major threats to society. New antibiotics are highly needed to cope with ... -
Development of an Analytical Method for the Determination of the Antigen Binding Capacity of Radiolabeled Antibodies
Andersen, Lene (Master thesis, 2012)The foundation of Algeta's second alpha-pharmaceutical platform is thorium-227, a radionuclide that emits alpha particles with high energy. By linking thorium-227 to tumor binding monoclonal antibodies, Algeta has the ... -
Diet and Life Stage-Associated Lipidome Remodeling in Atlantic Salmon
Jin, Yang; Harvey, Thomas Nelson; Bartosova, Zdenka; Hassani, Sahar; Bruheim, Per; Sandve, Simen Rød; Vik, Jon Olav (Peer reviewed; Journal article, 2021)Salmon is an important source of long-chain highly unsaturated fatty acids (LC-HUFAs) such as 22:6n-3 [docosahexaenoic acid (DHA)]. In the present study, we conducted two identical experiments on salmon in freshwater (FW) ... -
Differentially Regulated pathways of Potential Importance for Treatment Response and Cardiac Toxicity after Administration of Doxorubicine to BC Patients
Olsen, Tone (Master thesis, 2012)Doxorubicin is a topoisomerase-targeting anthracycline that is one of the most effective anticancer drugs currently known. However, its clinical use is restricted by cardiotoxicity and the development of drug resistance. ... -
Effects of Hypoxia on Cell Growth and Metabolism in the Leukemia Cell Line JJN-3 and Bladder Cancer Cell Line UM-UC-3
Langørgen, Ida Eide (Master thesis, 2018)Hypoxia is a condition in which the oxygen (O2) access is extremely reduced and thus limits the O2 available for cellular respiration. The hypoxic condition induces metabolic adjustments in the cells that permit further ... -
Effekt av endring i fermenteringsbetingelser på smak, i produksjon av øl
Korvald, Eirin (Master thesis, 2015)Ved produksjon av øl er det hovedsaklig fire ingredienser som brukes: vann, malt, humle og gjær. Gjæren står for fermenteringen av sukker til alkohol, men bidrar også med produksjon av andre smaksstoffer, for eksempel ... -
Elucidating the Impact of Various Physiological Conditions on Persister Cell Formation in Escherichia coli
Hovde Bø, Gaute (Master thesis, 2020)I løpet av dei siste tiåra har det vore ei stagnering i antibiotikautvikling samstundes som det har vore ei auking i førekomsten av antibiotikaresistens. Det er difor av stor interesse å få ei djupare forståing av dei ... -
Establishment of a Metabolite Extraction Method with MS-based Metabolite Profiling of Invasive Ductal Carcinoma Xenografts
Madsen, Trude Marita (Master thesis, 2012)Breast cancer is a complex disease comprising subtypes with varying clinical behavior, biological features and treatment response. Breast cancer heterogeneity characterized by different subtypes, is responsible for the ... -
Establishment of a Standardized Protocol and Assessing the Impact of Growth Phases for Persister Quantification
Brygmann, Elise (Master thesis, 2019)Persister er en subpopulasjon av celler i en bakteriekultur som har lang levetid ved antibiotika behandling. Persisterne oppstår hovedsakelig fra to mekanismer: trigget og spontant. Triggede persistere er et svar på cellulær ... -
Establishment of an Alginate-Based 3D Culture System of C2C12 Cells in Serum Free Medium and Investigation of the Metabolic Profiles
Scheffold, Jana (Master thesis, 2022)In vitro dyrket kjøtt, kjent som syntetisk kjøtt, er et fremvoksende felt innen bioteknologi med bakgrunn i miljøpåvirkning fra tradisjonell kjøttproduksjon og dyrevelferd. Derimot krever storskala produksjon av syntetisk ... -
Establishment of protocol for generation of human heart organoids derived from iPSCs
Solvang, Vanessa (Master thesis, 2021)Hjertet er av avgjørende betydning for menneskers helse og livskvalitet og forstyrrelser av dets funksjon kan ha livstruende konsekvenser. Ettersom dyremodeller ikke er i stand til å fullstendig representere detaljene i ... -
Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis
Rutkis, Reinis; Strazdina, Inese; Lasa, Zane; Bruheim, Per; Kalnenieks, Uldis (Peer reviewed; Journal article, 2021)Objective Zymomonas mobilis is an alpha-proteobacterium with a rapid ethanologenic pathway, involving Entner–Doudoroff (E–D) glycolysis, pyruvate decarboxylase (Pdc) and two alcohol dehydrogenase (ADH) isoenzymes. Pyruvate ... -
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
Fontana, Diletta; Mauri, Mario; Renso, Rossella; Docci, Mattia; Crespiatico, Ilaria; Røst, Lisa Marie; Jang, Mi; Niro, Antonio; D’Aliberti, Deborah; Massimino, Luca; Bertagna, Mayla; Zambrotta, Giovanni; Bossi, Mario; Citterio, Stefania; Crescenzi, Barbara; Fanelli, Francesca; Cassina, Valeria; Corti, Roberta; Salerno, Domenico; Nardo, Luca; Chinello, Clizia; Mantegazza, Francesco; Mecucci, Cristina; Magni, Fulvio; Cavaletti, Guido; Bruheim, Per; Larsen, Steen; Rea, Delphine; Gambacorti-Passerini, Carlo; Piazza, Rocco (Peer reviewed; Journal article, 2020)Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate in primary leukemic cells and in cell ...