Browsing NTNU Open by Author "Bofin, Anna M."
Now showing items 21-33 of 33
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PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes
Skjervold, Anette Hansen; Valla, Marit; Ytterhus, Borgny; Bofin, Anna M. (Peer reviewed; Journal article, 2023)Introduction P21-activated kinase 1 (PAK1) is known to be overexpressed in several human tumour types, including breast cancer (BC). It is located on chromosome 11 (11q13.5-q14.1) and plays a significant role in proliferation ... -
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy
Hansen, Ailin Falkmo; Høiem, Therese Stork; Selnæs, Kirsten Margrete; Bofin, Anna M.; Størkersen, Øystein; Bertilsson, Helena; Wright, Alan J.; Giskeødegård, Guro F.; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Peer reviewed; Journal article, 2023)Background The dual upregulation of TOP2A and EZH2 gene expression has been proposed as a biomarker for recurrence in prostate cancer patients to be treated with radical prostatectomy. A low tissue level of the metabolite ... -
Predictors of adherence and the role of primary non-adherence in antihormonal treatment of breast cancer
Dragvoll, Ida; Bofin, Anna M.; Søiland, Håvard; Taraldsen, Gunnar; Engstrøm, Monica J (Peer reviewed; Journal article, 2022)Background Antihormonal treatment for hormone receptor (HR) positive breast cancer has highly beneficial effects on both recurrence rates and survival. We investigate adherence and persistence in this group of ... -
Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer
Hansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan J; Bertilsson, Helena; Richardsen, Elin; Viset, Trond; Bofin, Anna M.; Angelsen, Anders; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2016)TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG by using an integrated ... -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
Cao, Maria Dung; Giskeødegård, Guro F.; Bathen, Tone Frost; Sitter, Beathe; Bofin, Anna M.; Lønning, Per Eystein; Lundgren, Steinar; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2012)Background Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced breast ... -
Quantifying tumour vascularity in non-luminal breast cancers
Kraby, Maria Ryssdal; Opdahl, Signe; Akslen, Lars A.; Bofin, Anna M. (Journal article; Peer reviewed, 2017)Aims Microvessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in histopathological sections. In this study, we assessed MVD, pMVD and VPI ... -
Reproducible lipid alterations in patient-derived breast cancer xenograft FFPE tissue identified with MALDI MSI for pre-clinical and clinical application
Denti, Vanna; Andersen, Maria Karoline; Smith, Andrew; Bofin, Anna M.; Nordborg, Anna; Magni, Fulvio; Moestue, Siver Andreas; Giampà, Marco (Peer reviewed; Journal article, 2021)The association between lipid metabolism and long-term outcomes is relevant for tumor diagnosis and therapy. Archival material such as formalin-fixed and paraffin embedded (FFPE) tissues is a highly valuable resource for ... -
S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes
Børkja, Mathieu; Giambelluca, Miriam Soledad; Ytterhus, Borgny; Prestvik, Wenche Slettahjell; Bjørkøy, Geir; Bofin, Anna M. (Peer reviewed; Journal article, 2023)Background and aims Amplification of S100A8 occurs in 10–30% of all breast cancers and has been linked to poorer prognosis. Similarly, the protein S100A8 is overexpressed in a roughly comparable proportion of breast cancers ... -
SFRP4 gene expression is increased in aggressive prostate cancer
Sandsmark, Elise; Andersen, Maria Karoline; Bofin, Anna M.; Bertilsson, Helena; Drabløs, Finn; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2017)Increased knowledge of the molecular differences between indolent and aggressive prostate cancer is needed for improved risk stratification and treatment selection. Secreted frizzled-related protein 4 (SFRP4) is a modulator ... -
Stromal collagen content in breast tumors correlates with in vivo diffusion-weighted imaging: A comparison of multi b-value DWI with histologic specimen from benign and malignant breast lesions
Egnell, Liv Elisabet; Vidic, Igor; Jerome, Neil Peter; Bofin, Anna M.; Bathen, Tone Frost; Goa, Pål Erik (Journal article; Peer reviewed, 2019)Background:Increased deposition and reorientation of stromal collagenfibers are associated with breast cancer progres-sion and invasiveness. Diffusion-weighted imaging (DWI) may be sensitive to the collagenfiber organization ... -
The prognostic value of androgen receptors in breast cancer subtypes
Kraby, Maria Ryssdal; Valla, Marit; Opdahl, Signe; Haugen, Olav Anton; Sawicka, Joanna Ewa; Engstrøm, Monica J; Bofin, Anna M. (Journal article; Peer reviewed, 2018)Purpose Androgen receptor (AR) expression is frequent in breast cancer and has been associated with good prognosis in several studies. The present study investigates AR-expression in relation to molecular subtypes, ... -
TOP2A gene copy number change in breast cancer
Engstrøm, Monica J; Ytterhus, Borgny; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Peer reviewed; Journal article, 2014)Aims The clinical significance of TOP2A as a prognostic marker has not been clarified. The aims of this study were to investigate the frequency of TOP2A copy number change; to correlate TOP2A with HER2 status, hormone ... -
Tumor-infiltrerende lymfocytter ved brystkreft – Assosiasjoner med overlevelse
Henriksen, Tommy (Master thesis, 2013)Innledning: Tumor-infiltrerende lymfocytter (TIL) har blitt assosiert med prognose ved flere kreftformer, men det er fortsatt debattert hvilken rolle de spiller ved brystkreft. Hensikten med studien var å undersøke om ...