Now showing items 21-29 of 29

    • MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity 

      Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2014-12-23)
      Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ...
    • N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2 

      Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)
      Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ...
    • Nephronectin in breast cancer progression and metastasis 

      Toraskar, Jimita Prashant (Doctoral theses at NTNU;2018:390, Doctoral thesis, 2018)
      Breast cancer is life threatening due to its ability to spread and invade other tissues. The best approach in solving a problem of this sort is to be able to reason backwards. Tumors appear chaotic as they are composed of ...
    • Novel pathways to metastasis of breast cancer 

      Wolowczyk, Camilla Izabel (Doctoral theses at NTNU;2020:397, Doctoral thesis, 2020)
      Ny diagnostikk for persontilpasset behandling av brystkreft Rundt 3600 kvinner blir årlig diagnostisert med brystkreft i Norge. Bedre diagnostikk og behandling bidrar til at flere enn 90% av brystkreftpasientene i dag ...
    • On the Identification of Features of Aggressive Breast Cancer Development 

      Neckmann, Ulrike (Doctoral theses at NTNU;2019:68, Doctoral thesis, 2019)
      Innføring av nasjonale mammografiprogrammer har ført til en økning av antall brystkrefttilfeller; først og fremst ikke-invasive tumorer. Vi vet at få av disse svulstene vil bli mestastatiske og dødelige, men vi mangler i ...
    • p62/SQSTM1 sin rolle i regulering av type I interferon-responsen i metastaserende brystkreftceller 

      Rylander, Felicia; Sritharan, Sajaki (Bachelor thesis, 2019)
      Kreft er en genetisk sykdom som karakteriseres av ukontrollert proliferasjon av celler i et vev. Brystkreft er en av de hyppigste kreftformene på verdensbasis, og har også flest overlevelser i Norge. Det er flere typiske ...
    • The Interplay of Oxidative Stress Responses and Autophagy in Inflammation 

      Mildenberger, Jennifer Melanie (Doctoral theses at NTNU;2017:186, Doctoral thesis, 2017)
      To assure homeostasis, cells have to continuously adapt to exogenous and endogenous threats. This is achieved by response mechanisms like the oxidative stress response, autophagy and inflammation. The oxidative stress ...
    • The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells 

      Johansson, Ida; Monsen, Vivi Anita Talstad; Pettersen, Kristine; Mildenberger, Jennifer; Misund, Kristine; Kaarniranta, Kai; Schønberg, Svanhild Margrethe Arentz; Bjørkøy, Geir (Journal article; Peer reviewed, 2015)
      Accumulation and aggregation of misfolded proteins is a hallmark of several diseases collectively known as proteinopathies. Autophagy has a cytoprotective role in diseases associated with protein aggregates. Age-related ...
    • Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking 

      Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)
      Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ...