Browsing NTNU Open by Author "Bjørkøy, Geir"

Now showing items 21-40 of 41

    • Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells 

      Starheim, Kristian Kobbenes; Holien, Toril; Misund, Kristine; Johansson, Ida; Baranowska, Katarzyna Anna; Sponaas, Anne Marit; Hella, Hanne; Buene, Glenn; Waage, Anders; Sundan, Anders; Bjørkøy, Geir (Journal article; Peer reviewed, 2016)
      Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, ...

    • KRAS-mutasjonsstatus i diagnostikk og behandling av kreft 

      Nordraak, Anne Ohren; Skog, Marte (Bachelor thesis, 2020)
      Kreft er en samlebetegnelse på en stor gruppe sykdommer, som har til felles at de starter med ukontrollert cellevekst. Kreftceller og tumorvev har helt spesielle egenskaper sammenlignet med normalt vev. Dette er seks ...

    • Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration 

      Felszeghy, Szabolcs; Viiri, Johanna; Paterno, Jussi J.; Hyttinen, Juha M.T.; Koskela, Ali; Chen, Mei; Leinonen, Henri; Tanila, Heikki; Kivinen, Niko; Koistinen, Arto; Toropainen, Elisa; Amadio, Marialaura; Smedowski, Adrian; Reinisalo, Mika; Winiarczyk, Mateusz; Mackiewicz, Jerzy; Mutikainen, Maija; Ruotsalainen, Anna-Kaisa; Kettunen, Mikko; Jokivarsi, Kimmo; Sinha, Debasish; Kinnunen, Kati; Petrovski, Goran; Blasiak, Janusz; Bjørkøy, Geir; Koskelainen, Ari; Skottman, Heli; Urtti, Arto; Salminen, Antero; Kannan, Ram; Ferrington, Deborah A.; Xu, Heping; Levonen, Anna-Liisa; Tavi, Pasi; Kauppinen, Anu; Kaarniranta, Kai (Journal article; Peer reviewed, 2019)
      Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves ...

    • Metodeetablering av long-range PCR for nøyaktig påvisning av klinisk relevante varianter i PRSS1-genet. 

      Skulberg, Magnus Barnholt; Andreassen, Kristoffer Emil (Bachelor thesis, 2020)
      Trypsinogen er et proenzym som omdannes til det viktige fordøyelsesenzymet trypsin i mange arter, deriblant mennesket. Genene som koder for de tre isoformene til trypsinogen er serin protease 1, 2 og 3, forkortet PRSS1, ...

    • Monitoring protein synthesis and degradation by metabolic AHA labeling and click chemistry based detection 

      Gärtner, Hanne Holm (Master thesis, 2014)
      The proteome determines the biochemical reactions that can be carried out by the cell, and is thus highly dynamic and tightly regulated by protein synthesis and degradation for adaption to environmental cues and cellular ...

    • MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity 

      Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2015)
      Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ...

    • MRI Reveals the in Vivo Cellular and Vascular Response to BEZ235 in Ovarian Cancer Xenografts with Different PI3-Kinase Pathway Activity 

      Cebulla, Jana; Huuse-Røneid, Else Marie; Pettersen, Kristine; van der Veen, Anna; Kim, Eugene; Andersen, Sonja; Prestvik, Wenche S; Bofin, Anna M.; Pathak, Arvind P; Bjørkøy, Geir; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2014-12-23)
      Background: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates ...

    • N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2 

      Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)
      Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ...

    • Nephronectin in breast cancer progression and metastasis 

      Toraskar, Jimita Prashant (Doctoral theses at NTNU;2018:390, Doctoral thesis, 2018)
      Breast cancer is life threatening due to its ability to spread and invade other tissues. The best approach in solving a problem of this sort is to be able to reason backwards. Tumors appear chaotic as they are composed of ...

    • Novel pathways to metastasis of breast cancer 

      Wolowczyk, Camilla Izabel (Doctoral theses at NTNU;2020:397, Doctoral thesis, 2020)
      Ny diagnostikk for persontilpasset behandling av brystkreft Rundt 3600 kvinner blir årlig diagnostisert med brystkreft i Norge. Bedre diagnostikk og behandling bidrar til at flere enn 90% av brystkreftpasientene i dag ...

    • NRF2 drives an oxidative stress response predictive of breast cancer 

      Wolowczyk, Camilla; Neckmann, Ulrike; Aure, Miriam Ragle; Hall, Martina; Johannessen, Bjarne; Zhao, Sen; Skotheim, Rolf I.; Andersen, Sonja Benedikte; Zwiggelaar, Rosalie Theda Margien; Steigedal, Tonje S.; Lingjærde, Ole Christian; Sahlberg, Kristine Kleivi; Almaas, Eivind; Bjørkøy, Geir (Peer reviewed; Journal article, 2022)
      Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting in overtreatment. To identify metastasis-related ...

    • On the Identification of Features of Aggressive Breast Cancer Development 

      Neckmann, Ulrike (Doctoral theses at NTNU;2019:68, Doctoral thesis, 2019)
      Innføring av nasjonale mammografiprogrammer har ført til en økning av antall brystkrefttilfeller; først og fremst ikke-invasive tumorer. Vi vet at få av disse svulstene vil bli mestastatiske og dødelige, men vi mangler i ...

    • Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer 

      Lamsal, Apsana; Andersen, Sonja Benedikte; Johansson, Ida; Vietri, Marina; Bokil, Ansooya Avinash; Kurganovs, Natalie Jayne; Rylander, Felicia; Bjørkøy, Geir; Pettersen, Kristine; Giambelluca, Miriam Soledad (Peer reviewed; Journal article, 2023)
      Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved ...

    • p62/SQSTM1 sin rolle i regulering av type I interferon-responsen i metastaserende brystkreftceller 

      Rylander, Felicia; Sritharan, Sajaki (Bachelor thesis, 2019)
      Kreft er en genetisk sykdom som karakteriseres av ukontrollert proliferasjon av celler i et vev. Brystkreft er en av de hyppigste kreftformene på verdensbasis, og har også flest overlevelser i Norge. Det er flere typiske ...

    • Pharmaceutical targeting of RIPK1-signaling: Characterization of cell death in human macrophage systems and therapeutic potential in multiple myeloma 

      Moen, Ingrid Nyhus (Doktoravhandlingar ved NTNU;2021:411, Doctoral thesis, 2021)
      The receptor-interacting protein kinase 1 (RIPK1)-pathway is a key regulator of inflammation and cell death. RIPK1-dependent cell death has been well studied in murine macrophages but as it is context dependent and differently ...

    • S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes 

      Børkja, Mathieu; Giambelluca, Miriam Soledad; Ytterhus, Borgny; Prestvik, Wenche Slettahjell; Bjørkøy, Geir; Bofin, Anna M. (Peer reviewed; Journal article, 2023)
      Background and aims Amplification of S100A8 occurs in 10–30% of all breast cancers and has been linked to poorer prognosis. Similarly, the protein S100A8 is overexpressed in a roughly comparable proportion of breast cancers ...

    • Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form 

      Aarhus, Thomas Ihle; Bjørnstad, Frithjof Andreas; Wolowczyk, Camilla Izabel; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjørkøy, Geir; Pridans, Clare; Eickhoff, Jan; Klebl, Bert; Hoff, Bård Helge; Sundby, Eirik (Peer reviewed; Journal article, 2023)
      Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible ...

    • TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy 

      Håland, Erling (Doctoral theses at NTNU;2024:74, Doctoral thesis, 2024)
      TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy Multiple myeloma is a hematological malignancy characterized by accumulation of malignant plasma cells in the bone marrow. This can lead to uncontrolled ...

    • The Interplay of Oxidative Stress Responses and Autophagy in Inflammation 

      Mildenberger, Jennifer Melanie (Doctoral theses at NTNU;2017:186, Doctoral thesis, 2017)
      To assure homeostasis, cells have to continuously adapt to exogenous and endogenous threats. This is achieved by response mechanisms like the oxidative stress response, autophagy and inflammation. The oxidative stress ...

    • The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells 

      Johansson, Ida; Monsen, Vivi Anita Talstad; Pettersen, Kristine; Mildenberger, Jennifer; Misund, Kristine; Kaarniranta, Kai; Schønberg, Svanhild Margrethe Arentz; Bjørkøy, Geir (Journal article; Peer reviewed, 2015)
      Accumulation and aggregation of misfolded proteins is a hallmark of several diseases collectively known as proteinopathies. Autophagy has a cytoprotective role in diseases associated with protein aggregates. Age-related ...