Blar i NTNU Open på forfatter "Børset, Magne"
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Phosphatases of regenerating liver are key regulators of metabolism in cancer cells - role of Serine/Glycine metabolism
Abdollahi, Pegah; Vandsemb, Esten Nymoen; Børset, Magne (Peer reviewed; Journal article, 2022)Purpose of review Phosphatases of regenerating liver (PRL) are dual-specificity phosphatases and comprise three members, PRL-1, -2 and -3. Despite the importance of PRLs as oncoproteins, there is no consensus function ... -
PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2
Vandsemb, Esten; Rye, Morten Beck; Steiro, Ida Johnsen; Elsaadi, Samah; Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Sponaas, Anne-Marit; Børset, Magne; Abdollahi, Pegah (Peer reviewed; Journal article, 2021)Multiple myeloma (MM) is an incurable hematologic malignancy resulting from the clonal expansion of plasma cells. MM cells are interacting with components of the bone marrow microenvironment such as cytokines to survive ... -
PRL-3 – et protein som ruster kreftceller til å leve med lav pH og O2
Huitfeldt, Ivar Espenes; Grøndalen, Andreas (Master thesis, 2023)Introduksjon: Myelomatose er en kreftsykdom som i hovedsak manifesterer seg i beinmargen, der differensierte plasmaceller gjennom genetiske aberrasjoner blir omdannet til maligne myelomceller. Cellene er tilpasset et svært ... -
PRL-3 – et protein som ruster kreftceller til å leve med lav pH og O2
Huitfeldt, Ivar Espenes; Grøndalen, Andreas (Master thesis, 2023)Introduksjon: Myelomatose er en kreftsykdom som i hovedsak manifesterer seg i beinmargen, der differensierte plasmaceller gjennom genetiske aberrasjoner blir omdannet til maligne myelomceller. Cellene er tilpasset et svært ... -
PRL-3–a signaling hub in Multiple Myeloma
Abdollahi, Pegah (Doctoral theses at NTNU;2017:131, Doctoral thesis, 2017)PRL-3 -en sentral aktør i myelomatsoecellens signalformidling: Myelomatose er en kreftform som oppstår i plasmaceller, den ferdig differensierte formen for B lymfocytter. Et kjennetegn på myelomatose er dens lokalisasjon ... -
Protein tyrosine phosphatases in multiple myeloma
Abdollahi, Pegah; Köhn, Maja; Børset, Magne (Peer reviewed; Journal article, 2020)Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even ... -
Raised serum levels of syndecan-1 (CD138), in a case of acute idiopathic systemic capillary leak syndrome (SCLS) (Clarkson's disease)
Bøe, Ole Wilhelm; Sveen, Kjell; Børset, Magne; Druey, Kirk M. (Journal article; Peer reviewed, 2018)BACKGROUND: Systemic capillary leak syndrome (SCLS) (Clarkson’s disease) is a rare disorder of unknown etiology, characterized by transient episodes of hypotension, and the microvascular leak of fluids into the peripheral ... -
Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3
Abdollahi, Pegah; Vandsemb, Esten Nymoen; Hjort, Magnus Aassved; Misund, Kristine; Holien, Toril; Sponaas, Anne-Marit; Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Børset, Magne (Journal article; Peer reviewed, 2016)Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of ... -
Targeting Cytosolic Phospholipase A2 alpha (cPLA2α) in Hematological Cancers and Inflammation
Mahammad, Nur (Doctoral theses at NTNU;2023:409, Doctoral thesis, 2023)Cytosolic phospholipase A2 alpha (cPLA2α) is an enzyme that plays a crucial role in regulating the balance between cellular growth and death by releasing the unsaturated fatty acid arachidonic acid from membrane lipids. ... -
Targeting phosphoglycerate dehydrogenase in multiple myeloma
Elsaadi, Samah; Steiro, Ida Johnsen; Abdollahi, Pegah; Vandsemb, Esten; Yang, Rui; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Menu, Eline; Sponaas, Anne-Marit; Børset, Magne (Peer reviewed; Journal article, 2021)Background: Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required. ... -
The Effect of Platelet Lysate as a Medium Supplement in Cultures of Human Multiple Myeloma
Bruvoll, Ingrid Engum (Master thesis, 2014)Multiple myeloma (MM) is a cancer of antibody-producing plasma cells in the bone marrow. It is the second most frequent hematological malignancy and comprises 1 % of all cancer. Most human myeloma cell lines (hMCLs) derived ... -
The influence of PRL3 on the IL-6 pathway in multiple myeloma: an explorative analysis using transcriptomics and proteomics
Vandsemb, Esten Nymoen (Master thesis, 2017)BACKGROUND: Multiple myeloma (MM) is an incurable malignancy of plasma cells. So far, blocking single growth factors, such as IL-6, has not led to improved patient survival in MM. We have previously published promising in ... -
Why do myeloma patients have bone disease? A historical perspective.
Børset, Magne; Sundan, Anders; Waage, Anders; Standal, Therese (Peer reviewed; Journal article, 2019)The question of how myeloma cells cause destruction of skeletal tissue has interested scientists for many years, and knowledge in this field has developed in parallel with the understanding of physiological bone remodeling. ...