Blar i NTNU Open på forfatter "Afset, Jan Egil"

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    • High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting 

      Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)
      Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ...

    • Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling 

      Moen, Siv Helen; Ehrnström, Birgitta; Kojen, June Frengen; Yurchenko, Mariya; Beckwith, Kai Sandvold; Afset, Jan Egil; Damås, Jan Kristian; Zhenyi, Hu; Hang, Yin; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2019)
      TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived ...

    • Incidence of invasive Group B Streptococcal infection and the risk of infant death and cerebral palsy: a Norwegian Cohort Study 

      Mynarek, Maren; Bjellmo, Solveig; Lydersen, Stian; Afset, Jan Egil; Andersen, Guro Lillemoen; Vik, Torstein (Peer reviewed; Journal article, 2020)
      Background Group B Streptococcus (GBS) is the leading cause of invasive neonatal infection worldwide. In high-income countries mortality rates are 4–10%, and among survivors of GBS meningitis 30–50% have neurodevelopmental ...

    • Investigation of an outbreak caused by antibiotic susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway 

      Rønning, Torunn Gresdal; Ås, Christina Gabrielsen; Støen, Ragnhild; Bergh, Kåre; Afset, Jan Egil; Holte, Mari Sagli; Radtke, Andreas (Journal article; Peer reviewed, 2018)
      Abstract Aim Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway ...

    • Kodepraksis ved sepsis 2008–21 

      Skei, Nina Vibeche; Afset, Jan Egil; Ehrnström, Anna Greta Birgitta; Nessan, Bente Sofie; Damås, Jan Kristian; Nilsen, Tom Ivar Lund; Gustad, Lise Tuset (Journal article; Peer reviewed, 2024)
      Bakgrunn:Sepsis har høy insidens og mortalitet. For planlegging av helsetjenester og i forskning trengs presise data, og det er behov for å kartlegge kodepraksis i Norge. Materiale og metode: Alle personer over 17 år som ...

    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...

    • Metodesammenligning av E-test mot agarfortynningsteknikk for undersøkelse av resistens mot Metronidazole i Helicobacter pylori 

      Belsås, Silje Svendsli; Lundin, Anna Linnea (Bachelor thesis, 2023)
      Bakgrunn: Fordi Helicobacter pylori (H.pylori) er både kravstor og saktevoksende er det svært viktig å benytte optimal dyrkningsmetode for å oppnå tilstrekkelig vekst for in-vitro undersøkelser. Bakterien har begynt å ...

    • Metodevalidering for påvisning av biofilmproduksjon hos Staphylococcus aureus 

      Conradsen, Sigurd Martinussen; Ginbot, Shenhet Zekgeb (Bachelor thesis, 2021)
      Biofilmproduksjon er en viktig fenotypisk egenskap hos en rekke bakteriearter sett i sammenheng med behandling av infeksjoner. I denne oppgaven ble det etablert og validert en semikvantitativ metode for fenotypisk påvisning ...

    • Molecular characterization and whole genome epidemiology of Staphylococcus aureus strains 

      Blomseth, Nora Berg (Master thesis, 2023)
      Staphylococcus aureus er både en kommensal bakterie som finnes på huden og i nesehulen, og en patogen bakterie kan forårsake en rekke alvorlige infeksjoner. Det er den nest vanligste årsaken til blodstrømsinfeksjon (BSI), ...

    • Mortality and neurodevelopmental outcome after invasive group B streptococcal infection in infants 

      Mynarek, Maren; Vik, Torstein; Andersen, Guro Lillemoen; Brigtsen, Anne Karin; Hollung, Sandra Julsen; Larose, Tricia L; Lydersen, Stian; Olsen, Lene Christin; Strøm, Marianne; Afset, Jan Egil (Peer reviewed; Journal article, 2023)
      Aim: To assess case fatality rate (CFR), infant mortality, and long-term neurodevelopmental disorders (NDDs) after invasive group B streptococcal (GBS; Streptococcus agalactiae) infection in infants. Method: Children born ...

    • Novel Synergistic Anti-Enteroviral Drug Combinations 

      Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)
      Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: ...

    • Outbreak of tularaemia in central Norway, January to March 2011 

      Larssen, Kjersti Wik; Afset, Jan Egil; Heier, Berit Tafjord; Krogh, Truls; Handeland, Kjell; Vikøren, Turid; Bergh, Kåre (Journal article; Peer reviewed, 2011)
      From January to March 2011, 39 cases of tularaemia were diagnosed in three counties in central Norway: 21 cases of oropharyngeal type, 10 cases of glandular/ulceroglandular type, two of respiratory and two of typhoid type. ...

    • Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection 

      Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning, Torunn Gresdal; Samuelsen, Ørjan; Ås, Christina Gabrielsen (Peer reviewed; Journal article, 2022)
      Introduction Thymine auxotrophic in vitro mutants of Escherichia coli were first reported in the mid-20th century. Later, thymine-dependent clinical strains of E. coli as well as other Enterobacterales, Enterococcus ...

    • Phylogeographical pattern of Francisella tularensis in a nationwide outbreak of tularaemia in Norway, 2011 

      Afset, Jan Egil; Larssen, Kjersti Wik; Bergh, Kåre; Lärkeryd, A; Sjodin, A; Johansson, A; Forsman, M (Journal article; Peer reviewed, 2015)
      In 2011, a nationwide outbreak of tularaemia occurred in Norway with 180 recorded cases. It was associated with the largest peak in lemming density seen in 40 years. Francisella tularensis was isolated from 18 patients. ...

    • Pneumocystis pneumonia in immunosuppressed patients - Epidemiological characterization and identification of diagnostic and prognostic markers 

      Grønseth, Stine (Doctoral theses at NTNU;2023:376, Doctoral thesis, 2023)
      Background Pneumocystis jirovecii is an opportunistic fungus and the causative agent of Pneumocystis pneumonia (PCP) in humans. PCP is foremost known as an AIDS-defining illness in people with advanced HIV-infection. ...

    • Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 

      Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...

    • Predicting in-hospital death from derived EHR trajectory features 

      Bopche, Rajeev; Gustad, Lise Tuset; Afset, Jan Egil; Damås, Jan Kristian; Nytrø, Øystein (Chapter, 2023)
      Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ...

    • Predicting In-Hospital Death from Derived EHR Trajectory Features 

      Bopche, Rajeev; Gustad, Lise Tuset; Afset, Jan Egil; Damås, Jan Kristian; Nytrø, Øystein (Chapter, 2024)
      Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ...

    • Prelabor rupture of membranes and the association with cerebral palsy in term born children: A national registry-based cohort study. 

      Mynarek, Maren; Bjellmo, Solveig; Lydersen, Stian; Strand, Kristin Melheim; Afset, Jan Egil; Andersen, Guro Lillemoen; Vik, Torstein (Journal article; Peer reviewed, 2020)
      Background Guidelines regarding management of prelabor rupture of membranes (PROM) at term vary between immediate induction and expectant management. A long interval between PROM and delivery increases the risk for ...

    • Prevalence of sexually transmitted infections among married women in rural Nepal 

      Shakya, Sunila; Tingulstad, Solveig; Syversen, Unni; Nordbø, Svein Arne; Madhup, Surendra; Vaidya, Krista; Karmacharya, Biraj Man; Åsvold, Bjørn Olav; Afset, Jan Egil (Journal article; Peer reviewed, 2018)
      Introduction. We have previously determined the prevalence of human papillomavirus (HPV) infection among women in rural Nepal. In the current study, we also wanted to examine the prevalence of and risk factors for other ...