Blar i NTNU Open på forfatter "Wiseth, Rune"
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3-D Doppler imaging in cardiac applications using high frame-rate sequences
Fiorentini, Stefano (Doctoral theses at NTNU;2020:60, Doctoral thesis, 2020)Several decades after the establishment of Doppler ultrasound, quantification and imaging of blood flow using Doppler-based techniques continue to face multiple challenges. Out-of-plane flow, transit-time broadening and ... -
Abnormal glucose regulation and coronary artery disease
Haug, Siril (Master thesis, 2016)Abnormal glucose regulation describes a condition with disturbed glucometabolic status. Patients with this abnormality have an increased risk of developing both micro- and macrovascular complications. Patients with abnormal ... -
Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study
Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2021)Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either ... -
The association between circulating lipoprotein subfractions and lipid content in coronary atheromatous plaques assessed by near-infrared spectroscopy
Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Gigante, Bruna; Giskeødegård, Guro F.; Bathen, Tone Frost; Follestad, Turid; Wiseth, Rune; Madssen, Erik; Bye, Anja (Peer reviewed; Journal article, 2023)Background Lipid content in coronary atheromatous plaques, measured by near-infrared spectroscopy (NIRS), can predict the risk of future coronary events. Biomarkers that reflect lipid content in coronary plaques may ... -
Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy
Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Taraldsen, Maria Dalen; Gigante, Bruna; Follestad, Turid; Røsjø, Helge Rørvik; Omland, Torbjørn; Wiseth, Rune; Madssen, Erik; Bye, Anja (Peer reviewed; Journal article, 2023)Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs ... -
Associations between circulating microRNAs, lipid content and plaque geometry in coronary atheromatous plaques assessed by near-infrared spectroscopy and intravascular ultrasound
Taraldsen, Maria Dalen (Doctoral theses at NTNU;2023:187, Doctoral thesis, 2023)Utredning og oppfølging av barn med hofteleddsdysplasi Hofteleddsdysplasi (DDH), også kallet «umodne hofteledd» hos barn, er en av de vanligste medfødte barneortopediske lidelser. Uten behandling kan det medføre smerter ... -
Behandling av hjerteinfarkt med ST-elevasjon – en observasjonsstudie
Arnesen, Julie Synnøve; Strøm, Knut Henrik; Bønaa, Kaare Harald; Wiseth, Rune (Peer reviewed; Journal article, 2019)BAKGRUNN Hjerteinfarkt med ST-elevasjon behandles med reperfusjon, enten med primær perkutan koronar intervensjon (PCI) eller med trombolytisk behandling. Behandlingsvalg avhenger av transporttid til nærmeste PCI-senter. ... -
BEtablocker Treatment After acute Myocardial Infarction in revascularized patients without reduced left ventricular ejection fraction (BETAMI): Rationale and design of a prospective, randomized, open, blinded end-point study
Munkhaugen, John; Ruddox, Vidar; Halvorsen, Sigrun; Dammen, Toril; Fagerland, Morten; Hernæs, Kjersti Helene; Vethe, Nils Tore; Prescott, Eva; Jensen, Svend Eggert; Rødevand, Olaf; Jortveit, Jarle; Bendz, Bjørn; Schirmer, Henrik; Kõber, Lars; Botker, Hans Erik; Larsen, Alf Inge; Vikenes, Kjell; Steigen, Terje; Wiseth, Rune; Pedersen, Terje Rolf; Edvardsen, Thor; Otterstad, Jan Erik; Atar, Dan (Peer reviewed; Journal article, 2019)Background - Current guidelines on the use of β-blockers in post–acute myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF) are based on studies before the implementation of modern ... -
CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trial
Vesterbekkmo, Elisabeth Kleivhaug; Madssen, Erik; Aksetøy, Inger-Lise Aamot; Follestad, Turid; Nilsen, Hans-Olav; Hegbom, Knut; Wisløff, Ulrik; Wiseth, Rune (Peer reviewed; Journal article, 2022)Background The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in ... -
Coronary artery occlusions diagnosed by transthoracic Doppler
Vegsundvåg, Johnny Åge; Holte, Espen; Wiseth, Rune; Hegbom, Knut; Hole, Torstein (Journal article; Peer reviewed, 2014)Background Our aim was to assess whether anterograde flow velocities in septal perforating branches could identify an occluded contralateral coronary artery, and to assess the feasibility and accuracy of diagnosing ... -
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Peer reviewed; Journal article, 2023)Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ... -
Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study
Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Rotevatn, Svein; Mannsverk, Jan Torbjørn; Larsen, Tommy; Larsby, Kristina; Skarstad, Sigrun; Fosse, Eivind Øygard; Dahl-Eriksen, Øystein; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2021)Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies ... -
Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar; Holte, Espen; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Espevik, Terje; Aakhus, Svend; Damås, Jan Kristian; Aukrust, Pål; Wiseth, Rune; Gullestad, Lars (Journal article; Peer reviewed, 2016)Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial ... -
The effect of drug-eluting stents on target lesion revascularization in native coronary arteries: Results from the NORSTENT randomized study
Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Melvær, Giil Lasse; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2020)Background: The NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) or bare-metal stent (BMS) with 5-year follow-up. No difference was found in the composite ... -
Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure
Høydal, Morten; Karevold, Asbjørn; Garstad, Idar Kirkeby; Wiseth, Rune; Haaverstad, Rune; Stølen, Tomas; Contu, Riccardo; Condorelli, Gianluigi; Ellingsen, Øyvind; Smith, Godfrey L; Kemi, Ole J; Wisløff, Ulrik (Journal article; Peer reviewed, 2018)Aims Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end‐stage heart failure (HF). To address this limitation, we provide data on ... -
IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction
Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their ... -
Impact of baseline coronary flow and its distribution on Fractional Flow Reserve prediction
Muller, Lucas Omar; Fossan, Fredrik Eikeland; Bråten, Anders Tjellaug; Jørgensen, Arve; Wiseth, Rune; Hellevik, Leif Rune (Journal article; Peer reviewed, 2019)Model‐based prediction of fractional flow reserve (FFR) in the context of stable coronary artery disease (CAD) diagnosis requires a number of modelling assumptions. One of these assumptions is the definition of a baseline ... -
Insomnia and risk for cardiovascular disease
Laugsand, Lars Erik Sande (Doctoral Theses at NTNU, 1503-8181; 2012:100, Doctoral thesis, 2012)Insomni og risiko for hjerte- og karsykdom Forskning som har blitt utført det siste tiåret har gitt resultater som taler for at dårlig søvn og søvnlidelser bidrar til utvikling av hjerte- og karsykdom. Insomni er definert ... -
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ... -
Interleukin-6 receptor inhibition in non-ST-elevation myocardial infarction - Results from a randomized clinical trial
Kleveland, Ola (Doctoral theses at NTNU;2019:50, Doctoral thesis, 2019)Norsk sammenfatning: Inhibering av interleukin-6 ved hjerteinfarkt uten ST-segment elevasjon i EKG. Resultater fra en randomisert klinisk studie. Dette arbeidet inneholder resultater fra en klinisk, randomisert, ...