Browsing NTNU Open by Author "Stølen, Tomas"
Now showing items 1-12 of 12
-
Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure
Johnsen, Anne Berit; Høydal, Morten Andre; Røsbjørgen, Ragnhild; Stølen, Tomas; Wisløff, Ulrik (Journal article; Peer reviewed, 2013)Background: There is limited knowledge about atrial myocyte Ca2+ handling in the failing hearts. The aim of this study was to examine atrial myocyte contractile function and Ca2+ handling in rats with post-infarction heart ... -
Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity
Johnsen, Anne Berit; Rolim, Natale Pinheiro Lage; Stølen, Tomas; Alves, Marcia; Sousa, Mirta; Slupphaug, Geir; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Wisløff, Ulrik; Høydal, Morten Andre (Peer reviewed; Journal article, 2013-10-16)Background: Although high aerobic capacity is associated with effective cardiac function, the effect of aerobic capacity on atrial function, especially in terms of cellular mechanisms, is not known. We aimed to investigate ... -
Characterization of Electrical Activity in Post-myocardial Infarction Scar Tissue in Rat Hearts Using Multiphoton Microscopy
Ghouri, Iffath A; Kelly, Allan; Salerno, Simona; Garten, Karin; Stølen, Tomas; Smith, Godfrey L (Journal article; Peer reviewed, 2018)Background: The origin of electrical behavior in post-myocardial infarction scar tissue is still under debate. This study aims to examine the extent and nature of the residual electrical activity within a stabilized ... -
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ... -
High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes
Bækkerud, Fredrik Hjulstad; Salerno, Simona; Ceriotti, Paola; Morland, Cecilie; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Høydal, Morten; Catalucci, Daniele; Stølen, Tomas (Journal article; Peer reviewed, 2019)UNIKARD (Project Number 217777/H10) -
Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure
Høydal, Morten; Karevold, Asbjørn; Garstad, Idar Kirkeby; Wiseth, Rune; Haaverstad, Rune; Stølen, Tomas; Contu, Riccardo; Condorelli, Gianluigi; Ellingsen, Øyvind; Smith, Godfrey L; Kemi, Ole J; Wisløff, Ulrik (Journal article; Peer reviewed, 2018)Aims Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end‐stage heart failure (HF). To address this limitation, we provide data on ... -
Investigation of cellular and structural basis of cardiac arrhythmias using two-photon microscopy
Salerno, Simona (Doctoral theses at NTNU;2020:165, Doctoral thesis, 2020)Cardiovascular diseases are often associated with arrhythmias, an electrical dysfunction in which the normal heart rhythm is disturbed. Arrhythmias are multifactorial phenomena, and understanding the mechanisms underlying ... -
MRS-based metabolic profiling of cardiac and skeletal muscle from rats with heart failure, low intrinsic fitness, aging and exercise training
Shi, Mingshu (Doctoral theses at NTNU;2019:371, Doctoral thesis, 2019)Background: Heart failure is associated with reduced exercise capacity and impaired myocardial and skeletal muscle metabolism. Other factors, such as inborn genetic difference, aging, and exercise training, can also lead ... -
Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training
Shi, Mingshu; Ellingsen, Øyvind; Bathen, Tone Frost; Høydal, Morten; Koch, Lauren G.; Britton, Steven L.; Wisløff, Ulrik; Stølen, Tomas; Esmaeili, Morteza (Journal article; Peer reviewed, 2018)Purpose Exercise training increases aerobic capacity and is beneficial for health, whereas low aerobic exercise capacity is a strong independent predictor of cardiovascular disease and premature death. The purpose of ... -
Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training
Shi, Mingshu; Ellingsen, Øyvind; Bathen, Tone Frost; Høydal, Morten; Koch, Lauren G.; Britton, Steven L.; Wisløff, Ulrik; Stølen, Tomas; Esmaeili, Morteza (Peer reviewed; Journal article, 2018)Purpose Exercise training increases aerobic capacity and is beneficial for health, whereas low aerobic exercise capacity is a strong independent predictor of cardiovascular disease and premature death. The purpose of the ... -
T cell costimulation blockade blunts pressure overload-induced heart failure
Kallikourdis, Marinos; Martini, Elisa; Carullo, Pierluigi; Sardi, Claudia; Roselli, Giuliana; Greco, Carolina M; Vignali, Debora; Riva, Federica; Berre, Anne Marie Ormbostad; Stølen, Tomas; Fumero, Andrea; Faggian, Giuseppe; Di Pasquale, Elisa; Elia, Leonardo; Rumio, Cristiano; Catalucci, Daniele; Papait, Roberto; Condorelli, Gianluigi (Journal article; Peer reviewed, 2017)Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual ... -
The effect of exercise training on myocardial and skeletal muscle metabolism by MR spectroscopy in rats with heart failure
Shi, Mingshu; Ellingsen, Øyvind; Bathen, Tone Frost; Høydal, Morten; Stølen, Tomas; Esmaeili, Morteza (Journal article; Peer reviewed, 2019)he metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the ...