Browsing NTNU Open by Author "Bruland, Torunn"
Now showing items 1-20 of 36
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5-ASA Affects the PPAR-gamma Protein Expression and Chemokine Release in Intestinal Epithelial Cells
Lokøy, Renate (Master thesis, 2024)Bakgrunn: Inflammatorisk tarm sykdom (IBD) er en kronisk immunologisk sykdom som består av ulcerøs kolitt (UC) og Crohn’s sykdom (CD). De karakteriseres av betennelse i fordøyelsessystemet, oftest i tarmene. Hva som ... -
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2018)The chemokine C-C motif ligand 20 (CCL20) is increased in the colonic mucosa during active inflammatory bowel disease (IBD) and can be found both in the epithelium and immune cells in the lamina propria. The present study ... -
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023) -
Dissecting the roles of ASPM and Clusterin in gastric oxyntic mucosa - from immature stem cells to metaplastic chief cells
Vange, Pål (Doctoral theses at NTNU;2018:289, Doctoral thesis, 2018)Gastric cancer is the third most common cause of cancer-related mortality worldwide. Increased understanding of initiation of gastric carcinogenesis and development of tools that enable early diagnosis are of critical ... -
Effects of Budesonide on the Intestinal Epithelium: Studies using IBD patient-derived Colonoids
Hammarqvist, Emilie Prytz (Master thesis, 2021)Bakgrunn: Tarmepitelcellene er etter hvert anerkjent som en viktig faktor i sykdomsbildet til inflammatoriske tarmsykdom (IBD). Det tradisjonelle anti-inflammatoriske steroid- legemiddelet budesonid er mye brukt i behandling ... -
Effects of Deucravacitinib in Intestinal Epithelial Cells
Cermakova, Romana (Master thesis, 2024)Bakgrunn: Inflammatorisk tarmsykdom (IBD), inkludert Crohns sykdom og ulcerøs kolitt, referer til en gruppe kroniske medisinske lidelser som forårsaker vedvarende betennelse i mage-tarmkanalen. Den eksakte årsaken til IBD ... -
Effects of JAK inhibitor Brepocitinib on Intestinal Epithelial Cells
Myrseth, Marte Gisvold (Master thesis, 2024)Bakgrunn og mål: Inflammatorisk tarmsykdom (IBD) inkluderer en gruppe kroniske inflammatoriske lidelser som påvirker fordøyelseskanalen. Tarmepitelceller spiller en viktig rolle i opprettholdelsen av homeostasen i tarmen ... -
Estimating Time-Continuous Gene Expression Profiles Using the Linear Mixed Effects Framework
Page, Christian Magnus (Master thesis, 2012)With the first generation of microarray experiments there were discussions and important arguments on how the samples should be treated. This included what kind of transformation and normalization procedures that the data ... -
Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Bruland, Torunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2015)Background: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are ... -
Gammadelta T cells in Crohn's disease: a new player in the disease pathogenesis?
catalan-Serra, Ignacio; Sandvik, Arne Kristian; Bruland, Torunn; Andreu-Ballester, Juan Carlos (Journal article; Peer reviewed, 2017)Crohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. An altered immune response to commensal intestinal bacteria takes place in genetically predisposed individuals, resulting ... -
Gastrin regulated activation of proteins in the elF2α-p-ATF4 network
Afroz, Wahida (Master thesis, 2013)This master's thesis is a part of a research project of The Gastroenterology Cell Biology Group investigating molecular responses to gastrin induced gene expression, with focus on how duration and intensity of gastrin ... -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis
Bruland, Torunn; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and ... -
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ... -
Intestinal epithelial ISG15 interactions with the immune system
Walaas, Gunnar Andreas (Master thesis, 2022)Introduksjon Inflammatorisk tarmsykdom (IBD) er en tilstand med kronisk inflammasjon i gastrointestinal traktus som utgjøres av sykdommene Crohns sykdom og ulcerøs kolitt. Det finnes ingen kur for IBD, men behandlingen er ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet (Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013) -
NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ...