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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

dc.contributor.authorWinkler, Thomas W.
dc.contributor.authorRasheed, Humaira
dc.contributor.authorTeumer, Alexander
dc.contributor.authorGorski, Mathias
dc.contributor.authorRowan, Bryce X.
dc.contributor.authorStanzick, Kira J.
dc.contributor.authorThomas, Laurent
dc.contributor.authorTin, Adrienne
dc.contributor.authorHoppmann, Anselm
dc.contributor.authorChu, Audrey Y.
dc.contributor.authorTayo, Bamidele
dc.contributor.authorThio, Chris H. L.
dc.contributor.authorCusi, Daniele
dc.contributor.authorChai, Jin-Fang
dc.contributor.authorSieber, Karsten B.
dc.contributor.authorHorn, Katrin
dc.contributor.authorLi, Man
dc.contributor.authorScholz, Markus
dc.contributor.authorCocca, Massimiliano
dc.contributor.authorWuttke, Matthias
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorYang, Qiong
dc.contributor.authorGhasemi, Sahar
dc.contributor.authorNutile, Teresa
dc.contributor.authorLi, Yong
dc.contributor.authorPontali, Giulia
dc.contributor.authorGünther, Felix
dc.contributor.authorDehghan, Abbas
dc.contributor.authorCorrea, Adolfo
dc.contributor.authorParsa, Afshin
dc.contributor.authorFeresin, Agnese
dc.contributor.authorde Vries, Aiko P. J.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorSmith, Albert V.
dc.contributor.authorOldehinkel, Albertine J.
dc.contributor.authorDe Grandi, Alessandro
dc.contributor.authorRosenkranz, Alexander R.
dc.contributor.authorFranke, Andre
dc.contributor.authorTeren, Andrej
dc.contributor.authorMetspalu, Andres
dc.contributor.authorHicks, Andrew A.
dc.contributor.authorMorris, Andrew P.
dc.contributor.authorTönjes, Anke
dc.contributor.authorMorgan, Anna
dc.contributor.authorPodgornaia, Anna I.
dc.contributor.authorPeters, Annette
dc.contributor.authorKörner, Antje
dc.contributor.authorMahajan, Anubha
dc.contributor.authorCampbell, Archie
dc.contributor.authorFreedman, Barry I.
dc.contributor.authorSpedicati, Beatrice
dc.contributor.authorPonte, Belen
dc.contributor.authorSchöttker, Ben
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorBanas, Bernhard
dc.contributor.authorKrämer, Bernhard K.
dc.contributor.authorJung, Bettina
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorSmith, Blair H.
dc.contributor.authorNing, Boting
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorVanderwerff, Brett R.
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorKammerer, Candace M.
dc.contributor.authorLangefeld, Carl D.
dc.contributor.authorHayward, Caroline
dc.contributor.authorSpracklen, Cassandra N.
dc.contributor.authorRobinson-Cohen, Cassianne
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorLindgren, Cecilia M.
dc.contributor.authorWang, Chaolong
dc.contributor.authorSabanayagam, Charumathi
dc.contributor.authorHeng, Chew-Kiat
dc.contributor.authorLanzani, Chiara
dc.contributor.authorKhor, Chiea-Chuen
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorFuchsberger, Christian
dc.contributor.authorGieger, Christian
dc.contributor.authorShaffer, Christian M.
dc.contributor.authorSchulz, Christina-Alexandra
dc.contributor.authorWiller, Cristen J.
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorGudbjartsson, Daniel F.
dc.contributor.authorRuggiero, Daniela
dc.contributor.authorToniolo, Daniela
dc.contributor.authorCzamara, Darina
dc.contributor.authorPorteous, David J.
dc.contributor.authorWaterworth, Dawn M.
dc.contributor.authorMascalzoni, Deborah
dc.contributor.authorMook-Kanamori, Dennis O.
dc.contributor.authorReilly, Dermot F.
dc.contributor.authorDaw, E. Warwick
dc.contributor.authorHofer, Edith
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorSalvi, Erika
dc.contributor.authorBottinger, Erwin P.
dc.contributor.authorTai, E-Shyong
dc.contributor.authorCatamo, Eulalia
dc.contributor.authorRizzi, Federica
dc.contributor.authorGuo, Feng
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorGuilianini, Franco
dc.contributor.authorSveinbjornsson, Gardar
dc.contributor.authorEhret, Georg
dc.contributor.authorWaeber, Gerard
dc.contributor.authorBiino, Ginevra
dc.contributor.authorGirotto, Giorgia
dc.contributor.authorPistis, Giorgio
dc.contributor.authorNadkarni, Girish N.
dc.contributor.authorDelgado, Graciela E.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorSnieder, Harold
dc.contributor.authorCampbell, Harry
dc.contributor.authorWhite, Harvey D.
dc.contributor.authorGao, He
dc.contributor.authorStringham, Heather M.
dc.contributor.authorSchmidt, Helena
dc.contributor.authorLi, Hengtong
dc.contributor.authorBrenner, Hermann
dc.contributor.authorHolm, Hilma
dc.contributor.authorKirsten, Holgen
dc.contributor.authorKramer, Holly
dc.contributor.authorRudan, Igor
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorOlafsson, Isleifur
dc.contributor.authorMartins, Jade
dc.contributor.authorCook, James P.
dc.contributor.authorWilson, James F.
dc.contributor.authorHalbritter, Jan
dc.contributor.authorFelix, Janine F.
dc.contributor.authorDivers, Jasmin
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorLee, Jeannette Jen-Mai
dc.contributor.authorO’Connell, Jeffrey
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorLiu, Jianjun
dc.contributor.authorXu, Jie
dc.contributor.authorThiery, Joachim
dc.contributor.authorÄrnlöv, Johan
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorJakobsdottir, Johanna
dc.contributor.authorTremblay, Johanne
dc.contributor.authorChambers, John C.
dc.contributor.authorWhitfield, John B.
dc.contributor.authorGaziano, John M.
dc.contributor.authorMarten, Jonathan
dc.contributor.authorCoresh, Josef
dc.contributor.authorJonas, Jost B.
dc.contributor.authorMychaleckyj, Josyf C.
dc.contributor.authorChristensen, Kaare
dc.contributor.authorEckardt, Kai-Uwe
dc.contributor.authorMohlke, Karen L.
dc.contributor.authorEndlich, Karlhans
dc.contributor.authorDittrich, Katalin
dc.contributor.authorRyan, Kathleen A.
dc.contributor.authorRice, Kenneth M.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorHo, Kevin
dc.contributor.authorNikus, Kjell
dc.contributor.authorMatsuda, Koichi
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorMiliku, Kozeta
dc.contributor.authorHveem, Kristian
dc.contributor.authorLind, Lars
dc.contributor.authorWallentin, Lars
dc.contributor.authorYerges-Armstrong, Laura M.
dc.contributor.authorRaffield, Laura M.
dc.contributor.authorPhillips, Lawrence S.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorLange, Leslie A.
dc.contributor.authorCitterio, Lorena
dc.contributor.authorKlaric, Lucija
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorIsing, Marcus
dc.contributor.authorKleber, Marcus E.
dc.contributor.authorFrancescatto, Margherita
dc.contributor.authorConcas, Maria Pina
dc.contributor.authorCiullo, Marina
dc.contributor.authorPiratsu, Mario
dc.contributor.authorOrho-Melander, Marju
dc.contributor.authorLaakso, Markku
dc.contributor.authorLoeffler, Markus
dc.contributor.authorPerola, Markus
dc.contributor.authorde Borst, Martin H.
dc.contributor.authorGögele, Martin
dc.contributor.authorBianca, Martina La
dc.contributor.authorLukas, Mary Ann
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorBiggs, Mary L.
dc.contributor.authorWojczynski, Mary K.
dc.contributor.authorKavousi, Maryam
dc.contributor.authorKanai, Masahiro
dc.contributor.authorAkiyama, Masato
dc.contributor.authorYasuda, Masayuki
dc.contributor.authorNauck, Matthias
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorChee, Miao-Li
dc.contributor.authorChee, Miao-Ling
dc.contributor.authorBoehnke, Michael
dc.contributor.authorPreuss, Michael H.
dc.contributor.authorStumvoll, Michael
dc.contributor.authorProvince, Michael A.
dc.contributor.authorEvans, Michele K.
dc.contributor.authorO’Donoghue, Michelle L.
dc.contributor.authorKubo, Michiaki
dc.contributor.authorKähönen, Mika
dc.contributor.authorKastarinen, Mika
dc.contributor.authorNalls, Mike A.
dc.contributor.authorKuokkanen, Mikko
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorBochud, Murielle
dc.contributor.authorJosyula, Navya Shilpa
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorTan, Nicholas Y. Q.
dc.contributor.authorPalmer, Nicholette D.
dc.contributor.authorPirastu, Nicola
dc.contributor.authorSchupf, Nicole
dc.contributor.authorVerweij, Niek
dc.contributor.authorHutri-Kähönen, Nina
dc.contributor.authorMononen, Nina
dc.contributor.authorBansal, Nisha
dc.contributor.authorDevuyst, Olivier
dc.contributor.authorMelander, Olle
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorPolasek, Ozren
dc.contributor.authorManunta, Paolo
dc.contributor.authorGasparini, Paolo
dc.contributor.authorMishra, Pashupati P.
dc.contributor.authorSulem, Patrick
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorElliott, Paul
dc.contributor.authorRidker, Paul M.
dc.contributor.authorHamet, Pavel
dc.contributor.authorSvensson, Per O.
dc.contributor.authorJoshi, Peter K.
dc.contributor.authorKovacs, Peter
dc.contributor.authorPramstaller, Peter P.
dc.contributor.authorRossing, Peter
dc.contributor.authorVollenweider, Peter
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorDorajoo, Rajkumar
dc.contributor.authorSim, Ralene Z. H.
dc.contributor.authorBurkhardt, Ralph
dc.contributor.authorTao, Ran
dc.contributor.authorNoordam, Raymond
dc.contributor.authorMägi, Reedik
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorRueedi, Rico
dc.contributor.authorvan Dam, Rob M.
dc.contributor.authorCarroll, Robert J.
dc.contributor.authorGansevoort, Ron T.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorFelicita, Sala Cinzia
dc.contributor.authorSedaghat, Sanaz
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorFreitag-Wolf, Sandra
dc.contributor.authorPendergrass, Sarah A.
dc.contributor.authorGraham, Sarah E.
dc.contributor.authorGordon, Scott D.
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorKerr, Shona M.
dc.contributor.authorVaccargiu, Simona
dc.contributor.authorPatil, Snehal B.
dc.contributor.authorHallan, Stein
dc.contributor.authorBakker, Stephan J. L.
dc.contributor.authorLim, Su-Chi
dc.contributor.authorLucae, Susanne
dc.contributor.authorVogelezang, Suzanne
dc.contributor.authorBergmann, Sven
dc.contributor.authorCorre, Tanguy
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorBoutin, Thibaud S.
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorWong, Tien-Yin
dc.contributor.authorBergler, Tobias
dc.contributor.authorRabelink, Ton J.
dc.contributor.authorEsko, Tõnu
dc.contributor.authorHaller, Toomas
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorVölker, Uwe
dc.contributor.authorFoo, Valencia Hui Xian
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorVitart, Veronique
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorJaddoe, Vincent W. V.
dc.contributor.authorHuang, Wei
dc.contributor.authorZhang, Weihua
dc.contributor.authorWei, Wen Bin
dc.contributor.authorKiess, Wieland
dc.contributor.authorMärz, Winfried
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorLieb, Wolfgang
dc.contributor.authorGao, Xin
dc.contributor.authorSim, Xueling
dc.contributor.authorWang, Ya Xing
dc.contributor.authorFriedlander, Yechiel
dc.contributor.authorTham, Yih-Chung
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorOkada, Yukinori
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorYu, Zhi
dc.contributor.authorThio, Chris H. L.
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorde Borst, Martin H.
dc.contributor.authorHo, Kevin
dc.contributor.authorJosyula, Navya Shilpa
dc.contributor.authorPendergrass, Sarah A.
dc.contributor.authorRowan, Bryce X.
dc.contributor.authorRobinson-Cohen, Cassianne
dc.contributor.authorGaziano, John M.
dc.contributor.authorPhillips, Lawrence S.
dc.contributor.authorTao, Ran
dc.contributor.authorHung, Adriana M.
dc.contributor.authorStark, Klaus J.
dc.contributor.authorStefansson, Kari
dc.contributor.authorBöger, Carsten A.
dc.contributor.authorHung, Adriana M.
dc.contributor.authorKronenberg, Florian
dc.contributor.authorKöttgen, Anna
dc.contributor.authorPattaro, Cristian
dc.contributor.authorHeid, Iris M.
dc.date.accessioned2023-01-31T15:22:20Z
dc.date.available2023-01-31T15:22:20Z
dc.date.created2022-09-15T10:42:26Z
dc.date.issued2022
dc.identifier.citationCommunications Biology. 2022, 5 (1), .en_US
dc.identifier.issn2399-3642
dc.identifier.urihttps://hdl.handle.net/11250/3047490
dc.description.abstractReduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individualsen_US
dc.title.alternativeDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individualsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber0en_US
dc.source.volume5en_US
dc.source.journalCommunications Biologyen_US
dc.source.issue1en_US
dc.identifier.doi10.1038/s42003-022-03448-z
dc.identifier.cristin2051922
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal