dc.contributor.author | Papoutsis, Iosif | |
dc.contributor.author | Knudtsen, Ingerid Skjei | |
dc.contributor.author | Sande, Erlend Peter Skaug | |
dc.contributor.author | Rekstad, Bernt Louni | |
dc.contributor.author | Öllers, Michel | |
dc.contributor.author | van Elmpt, Wouter | |
dc.contributor.author | Arnesen, Marius Røthe | |
dc.contributor.author | Malinen, Eirik | |
dc.date.accessioned | 2023-01-18T12:41:42Z | |
dc.date.available | 2023-01-18T12:41:42Z | |
dc.date.created | 2022-05-02T13:49:32Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Physics and imaging in radiation oncology (PIRO). 2022, 21 101-107. | en_US |
dc.identifier.issn | 2405-6316 | |
dc.identifier.uri | https://hdl.handle.net/11250/3044311 | |
dc.description.abstract | Background and purpose
Dose painting by numbers (DPBN) require a high degree of dose modulation to fulfill the image-based voxel wise dose prescription. The aim of this study was to assess the dosimetric accuracy of 18F-fluoro-2-deoxy-glucose positron emission tomography(18F-FDG-PET)-based DPBN in an anthropomorphic lung phantom using alanine dosimetry.
Materials and methods
A linear dose prescription based on 18F-FDG-PET image intensities within the gross tumor volume (GTV) of a lung cancer patient was employed. One DPBN scheme with low dose modulation (Scheme A; minimum/maximum fraction dose to the GTV 2.92/4.26 Gy) and one with a high modulation (Scheme B; 2.81/4.52 Gy) were generated. The plans were transferred to a computed tomograpy (CT) scan of a thorax phantom based on CT images of the patient. Using volumetric modulated arc therapy (VMAT), DPBN was delivered to the phantom with embedded alanine dosimeters. A plan was also delivered to an intentionally misaligned phantom. Absorbed doses at various points in the phantom were measured by alanine dosimetry.
Results
A pointwise comparison between GTV doses from prescription, treatment plan calculation and VMAT delivery showed high correspondence, with a mean and maximum dose difference of <0.1 Gy and 0.3 Gy, respectively. No difference was found in dosimetric accuracy between scheme A and B. The misalignment caused deviations up to 1 Gy between prescription and delivery.
Conclusion
DPBN can be delivered with high accuracy, showing that the treatment may be applied correctly from a dosimetric perspective. Still, misalignment may cause considerable dosimetric erros, indicating the need for patient immobilization and monitoring. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom | en_US |
dc.title.alternative | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 101-107 | en_US |
dc.source.volume | 21 | en_US |
dc.source.journal | Physics and imaging in radiation oncology (PIRO) | en_US |
dc.identifier.doi | 10.1016/j.phro.2022.02.013 | |
dc.identifier.cristin | 2020698 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |