dc.contributor.author | Patrono, Livia V. | |
dc.contributor.author | Vrancken, Bram | |
dc.contributor.author | Budt, Matthias | |
dc.contributor.author | Düx, Ariane | |
dc.contributor.author | Lequime, Sebastian | |
dc.contributor.author | Boral, Sengül | |
dc.contributor.author | Gilbert, Marcus Thomas Pius | |
dc.contributor.author | Gogarten, Jan F. | |
dc.contributor.author | Hoffmann, Luisa | |
dc.contributor.author | Horst, David | |
dc.contributor.author | Merkel, Kevin | |
dc.contributor.author | Morens, David | |
dc.contributor.author | Prepoint, Baptiste | |
dc.contributor.author | Schlotterbeck, Jasmin | |
dc.contributor.author | Schuenemann, Verena J. | |
dc.contributor.author | Suchard, Marc A. | |
dc.contributor.author | Taubenberger, Jeffery K. | |
dc.contributor.author | Tenkhoff, Luisa | |
dc.contributor.author | Urban, Christian | |
dc.contributor.author | Widulin, Navena | |
dc.contributor.author | Winter, Eduard | |
dc.contributor.author | Worobey, Michael | |
dc.contributor.author | Schnalke, Thomas | |
dc.contributor.author | Wolff, Thorsten | |
dc.contributor.author | Lemey, Philippe | |
dc.contributor.author | Calvignac-Spencer, Sébastien | |
dc.date.accessioned | 2023-01-17T10:10:55Z | |
dc.date.available | 2023-01-17T10:10:55Z | |
dc.date.created | 2022-10-18T13:29:16Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Nature Communications. 2022, 13 . | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/3043927 | |
dc.description.abstract | The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic | en_US |
dc.title.alternative | Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 9 | en_US |
dc.source.volume | 13 | en_US |
dc.source.journal | Nature Communications | en_US |
dc.identifier.doi | 10.1038/s41467-022-29614-9 | |
dc.identifier.cristin | 2062406 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |