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Serum metabolome associated with severity of acute traumatic brain injury

dc.contributor.authorThomas, Ilias
dc.contributor.authorDickens, Alex M.
dc.contributor.authorPosti, Jussi P.
dc.contributor.authorCzeiter, Endre
dc.contributor.authorDuberg, Daniel
dc.contributor.authorSinioja, Tim
dc.contributor.authorKråkström, Matilda
dc.contributor.authorRetel Helmrich, Isabel R. A.
dc.contributor.authorWang, Kevin K. W.
dc.contributor.authorMaas, Andrew I. R.
dc.contributor.authorSteyerberg, Ewout W.
dc.contributor.authorMenon, David K.
dc.contributor.authorTenovuo, Olli
dc.contributor.authorHyötyläinen, Tuulia
dc.contributor.authorBüki, András
dc.contributor.authorOrešič, Matej
dc.contributor.authorÅkerlund, Cecilia
dc.contributor.authorAmrein, Krisztina
dc.contributor.authorAndelic, Nada
dc.contributor.authorAndreassen, Lasse
dc.contributor.authorAnke, Audny Gabriele Wagner
dc.contributor.authorAntoni, Anna
dc.contributor.authorAudibert, Gérard
dc.contributor.authorAzouvi, Philippe
dc.contributor.authorAzzolini, Maria Luisa
dc.contributor.authorBartels, Ronald
dc.contributor.authorBarzó, Pál
dc.contributor.authorBeauvais, Romuald
dc.contributor.authorBeer, Ronny
dc.contributor.authorBellander, Bo-Michael
dc.contributor.authorBelli, Antonio
dc.contributor.authorBenali, Habib
dc.contributor.authorBerardino, Maurizio
dc.contributor.authorBeretta, Luigi
dc.contributor.authorBlaabjerg, Morten
dc.contributor.authorBragge, Peter
dc.contributor.authorBrazinova, Alexandra
dc.contributor.authorBrinck, Vibeke
dc.contributor.authorBrooker, Joanne
dc.contributor.authorBrorsson, Camilla
dc.contributor.authorBullinger, Monika
dc.contributor.authorCabeleira, Manuel
dc.contributor.authorCaccioppola, Alessio
dc.contributor.authorCalappi, Emiliana
dc.contributor.authorCalvi, Maria Rosa
dc.contributor.authorCameron, Peter
dc.contributor.authorLozano, Guillermo Carbayo
dc.contributor.authorCarbonara, Marco
dc.contributor.authorCavallo, Simona
dc.contributor.authorChevallard, Giorgio
dc.contributor.authorChieregato, Arturo
dc.contributor.authorCiterio, Giuseppe
dc.contributor.authorClusmann, Hans
dc.contributor.authorCoburn, Mark
dc.contributor.authorColes, Jonathan
dc.contributor.authorCooper, Jamie D.
dc.contributor.authorCorreia, Marta
dc.contributor.authorČović, Amra
dc.contributor.authorCurry, Nicola
dc.contributor.authorCzeiter, Endre
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorDahyot-Fizelier, Claire
dc.contributor.authorDark, Paul
dc.contributor.authorDawes, Helen
dc.contributor.authorDe Keyser, Véronique
dc.contributor.authorDegos, Vincent
dc.contributor.authorCorte, Francesco Della
dc.contributor.authorden Boogert, Hugo
dc.contributor.authorDepreitere, Bart
dc.contributor.authorĐilvesi, Đula
dc.contributor.authorDixit, Abhishek
dc.contributor.authorDonoghue, Emma
dc.contributor.authorDreier, Jens
dc.contributor.authorDulière, Guy-Loup
dc.contributor.authorErcole, Ari
dc.contributor.authorEsser, Patrick
dc.contributor.authorEzer, Erzsébet
dc.contributor.authorFabricius, Martin
dc.contributor.authorFeigin, Valery L.
dc.contributor.authorFoks, Kelly
dc.contributor.authorFrisvold, Shirin
dc.contributor.authorFurmanov, Alex
dc.contributor.authorGagliardo, Pablo
dc.contributor.authorGalanaud, Damien
dc.contributor.authorGantner, Dashiell
dc.contributor.authorGao, Guoyi
dc.contributor.authorGeorge, Pradeep
dc.contributor.authorGhuysen, Alexandre
dc.contributor.authorGiga, Lelde
dc.contributor.authorGlocker, Ben
dc.contributor.authorGolubovic, Jagoš
dc.contributor.authorGomez, Pedro A.
dc.contributor.authorGratz, Johannes
dc.contributor.authorGravesteijn, Benjamin
dc.contributor.authorGrossi, Francesca
dc.contributor.authorGruen, Russell L.
dc.contributor.authorGupta, Deepak
dc.contributor.authorHaagsma, Juanita A.
dc.contributor.authorHaitsma, Iain
dc.contributor.authorHelbok, Raimund
dc.contributor.authorHelseth, Eirik
dc.contributor.authorHorton, Lindsay
dc.contributor.authorHuijben, Jilske
dc.contributor.authorHutchinson, Peter J.
dc.contributor.authorJacobs, Bram
dc.contributor.authorJankowski, Stefan
dc.contributor.authorJarrett, Mike
dc.contributor.authorJiang, Ji-yao
dc.contributor.authorJohnson, Faye
dc.contributor.authorJones, Kelly
dc.contributor.authorKaran, Mladen
dc.contributor.authorKolias, Angelos G.
dc.contributor.authorKompanje, Erwin
dc.contributor.authorKondziella, Daniel
dc.contributor.authorKornaropoulos, Evgenios
dc.contributor.authorKoskinen, Lars-Owe
dc.contributor.authorKovács, Noémi
dc.contributor.authorKowark, Ana
dc.contributor.authorLagares, Alfonso
dc.contributor.authorLanyon, Linda
dc.contributor.authorLaureys, Steven
dc.contributor.authorLecky, Fiona
dc.contributor.authorLedoux, Didier
dc.contributor.authorLefering, Rolf
dc.contributor.authorLegrand, Valerie
dc.contributor.authorLejeune, Aurelie
dc.contributor.authorLevi, Leon
dc.contributor.authorLightfoot, Roger
dc.contributor.authorLingsma, Hester
dc.contributor.authorMaas, Andrew I. R.
dc.contributor.authorCastaño-León, Ana M.
dc.contributor.authorMaegele, Marc
dc.contributor.authorMajdan, Marek
dc.contributor.authorManara, Alex
dc.contributor.authorManley, Geoffrey
dc.contributor.authorMartino, Costanza
dc.contributor.authorMaréchal, Hugues
dc.contributor.authorMattern, Julia
dc.contributor.authorMcMahon, Catherine
dc.contributor.authorMelegh, Béla
dc.contributor.authorMenovsky, Tomas
dc.contributor.authorMikolic, Ana
dc.contributor.authorMisset, Benoit
dc.contributor.authorMuraleedharan, Visakh
dc.contributor.authorMurray, Lynnette
dc.contributor.authorNegru, Ancuta
dc.contributor.authorNelson, David
dc.contributor.authorNewcombe, Virginia
dc.contributor.authorNieboer, Daan
dc.contributor.authorNyirádi, József
dc.contributor.authorOlubukola, Otesile
dc.contributor.authorOrtolano, Fabrizio
dc.contributor.authorPalotie, Aarno
dc.contributor.authorParizel, Paul M.
dc.contributor.authorPayen, Jean-François
dc.contributor.authorPerera, Natascha
dc.contributor.authorPerlbarg, Vincent
dc.contributor.authorPersona, Paolo
dc.contributor.authorPeul, Wilco
dc.contributor.authorPiippo-Karjalainen, Anna
dc.contributor.authorPirinen, Matti
dc.contributor.authorPles, Horia
dc.contributor.authorPolinder, Suzanne
dc.contributor.authorPomposo, Inigo
dc.contributor.authorPosti, Jussi P.
dc.contributor.authorPuybasset, Louis
dc.contributor.authorRadoi, Andreea
dc.contributor.authorRagauskas, Arminas
dc.contributor.authorRaj, Rahul
dc.contributor.authorRambadagalla, Malinka
dc.contributor.authorRhodes, Jonathan
dc.contributor.authorRichardson, Sylvia
dc.contributor.authorRichter, Sophie
dc.contributor.authorRipatti, Samuli
dc.contributor.authorRocka, Saulius
dc.contributor.authorRøe, Cecilie
dc.contributor.authorRøise, Olav
dc.contributor.authorRosand, Jonathan
dc.contributor.authorRosenfeld, Jeffrey V.
dc.contributor.authorRosenlund, Christina
dc.contributor.authorRosenthal, Guy
dc.contributor.authorRossaint, Rolf
dc.contributor.authorRossi, Sandra
dc.contributor.authorRueckert, Daniel
dc.contributor.authorRusnák, Martin
dc.contributor.authorSahuquillo, Juan
dc.contributor.authorSakowitz, Oliver
dc.contributor.authorSanchez-Porras, Renan
dc.contributor.authorSandor, Janos
dc.contributor.authorSchäfer, Nadine
dc.contributor.authorSchmidt, Silke
dc.contributor.authorSchoechl, Herbert
dc.contributor.authorSchoonman, Guus
dc.contributor.authorSchou, Rico Frederik
dc.contributor.authorSchwendenwein, Elisabeth
dc.contributor.authorSewalt, Charlie
dc.contributor.authorSkandsen, Toril
dc.contributor.authorSmielewski, Peter
dc.contributor.authorSorinola, Abayomi
dc.contributor.authorStamatakis, Emmanuel
dc.contributor.authorStanworth, Simon
dc.contributor.authorStevens, Robert
dc.contributor.authorStewart, William
dc.contributor.authorStocchetti, Nino
dc.contributor.authorSundström, Nina
dc.contributor.authorTakala, Riikka
dc.contributor.authorTamás, Viktória
dc.contributor.authorTamosuitis, Tomas
dc.contributor.authorTaylor, Mark Steven
dc.contributor.authorTe Ao, Braden
dc.contributor.authorTheadom, Alice
dc.contributor.authorThomas, Matt
dc.contributor.authorTibboel, Dick
dc.contributor.authorTimmers, Marjolein
dc.contributor.authorTolias, Christos
dc.contributor.authorTrapani, Tony
dc.contributor.authorTudora, Cristina Maria
dc.contributor.authorUnterberg, Andreas
dc.contributor.authorVajkoczy, Peter
dc.contributor.authorVallance, Shirley
dc.contributor.authorValeinis, Egils
dc.contributor.authorVámos, Zoltán
dc.contributor.authorvan der Jagt, Mathieu
dc.contributor.authorVan der Steen, Gregory
dc.contributor.authorvan der Naalt, Joukje
dc.contributor.authorvan Dijck, Jeroen T. J. M.
dc.contributor.authorvan Essen, Thomas A.
dc.contributor.authorVan Hecke, Wim
dc.contributor.authorvan Heugten, Caroline
dc.contributor.authorVan Praag, Dominique
dc.contributor.authorVyvere, Thijs Vande
dc.contributor.authorvan Wijk, Roel P. J.
dc.contributor.authorVargiolu, Alessia
dc.contributor.authorVega, Emmanuel
dc.contributor.authorVelt, Kimberley
dc.contributor.authorVerheyden, Jan
dc.contributor.authorVespa, Paul M.
dc.contributor.authorVik, Anne
dc.contributor.authorVilcinis, Rimantas
dc.contributor.authorVolovici, Victor
dc.contributor.authorvon Steinbüchel, Nicole
dc.contributor.authorVoormolen, Daphne
dc.contributor.authorVulekovic, Petar
dc.contributor.authorWiegers, Eveline
dc.contributor.authorWilliams, Guy
dc.contributor.authorWilson, Lindsay
dc.contributor.authorWinzeck, Stefan
dc.contributor.authorWolf, Stefan
dc.contributor.authorYang, Zhihui
dc.contributor.authorYlén, Peter
dc.contributor.authorYounsi, Alexander
dc.contributor.authorZeiler, Frederick A.
dc.contributor.authorZelinkova, Veronika
dc.contributor.authorZiverte, Agate
dc.contributor.authorZoerle, Tommaso
dc.date.accessioned2022-12-05T07:42:09Z
dc.date.available2022-12-05T07:42:09Z
dc.date.created2022-10-12T11:54:08Z
dc.date.issued2022
dc.identifier.citationNature Communications. 2022, 13 (1), 1-15.en_US
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11250/3035746
dc.description.abstractComplex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleSerum metabolome associated with severity of acute traumatic brain injuryen_US
dc.title.alternativeSerum metabolome associated with severity of acute traumatic brain injuryen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-15en_US
dc.source.volume13en_US
dc.source.journalNature Communicationsen_US
dc.source.issue1en_US
dc.identifier.doi10.1038/s41467-022-30227-5
dc.identifier.cristin2060796
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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