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dc.contributor.authorIanevski, Aleksandr
dc.contributor.authorSimonsen, Ronja Meyer
dc.contributor.authorMyhre, Vegard
dc.contributor.authorTenson, Tanel
dc.contributor.authorOksenych, Valentyn
dc.contributor.authorBjørås, Magnar
dc.contributor.authorKainov, Denis
dc.date.accessioned2022-09-29T13:49:14Z
dc.date.available2022-09-29T13:49:14Z
dc.date.created2022-05-26T17:16:38Z
dc.date.issued2022
dc.identifier.citationNucleic Acids Research (NAR). 2022, .en_US
dc.identifier.issn0305-1048
dc.identifier.urihttps://hdl.handle.net/11250/3022582
dc.description.abstractViruses can cross species barriers and cause unpredictable outbreaks in man with substantial economic and public health burdens. Broad-spectrum antivirals, (BSAs, compounds inhibiting several human viruses), and BSA-containing drug combinations (BCCs) are deemed as immediate therapeutic options that fill the void between virus identification and vaccine development. Here, we present DrugVirus.info 2.0 (https://drugvirus.info), an integrative interactive portal for exploration and analysis of BSAs and BCCs, that greatly expands the database and functionality of DrugVirus.info 1.0 webserver. Through the data portal that now expands the spectrum of BSAs and provides information on BCCs, we developed two modules for (i) interactive analysis of users’ own antiviral drug and combination screening data and their comparison with published datasets, and (ii) exploration of the structure–activity relationship between various BSAs. The updated portal provides an essential toolbox for antiviral drug development and repurposing applications aiming to identify existing and novel treatments of emerging and re-emerging viral threats.en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleDrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)en_US
dc.title.alternativeDrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber4en_US
dc.source.journalNucleic Acids Research (NAR)en_US
dc.identifier.doi10.1093/nar/gkac348
dc.identifier.cristin2027593
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal