New insights into the genetic etiology of Alzheimer's disease and related dementias
Bellenguez, Céline; Küçükali, Fahri; Jansen, Iris E.; Kleineidam, Luca; Moreno-Grau, Sonia; Amin, Najaf; Naj, Adam C.; Campos-Martin, Rafael; Grenier-Boley, Benjamin; Andrade, Victor; Holmans, Peter A.; Boland, Anne; Damotte, Vincent; van der Lee, Sven J.; Costa, Marcos R.; Kuulasmaa, Teemu; Yang, Qiong; de Rojas, Itziar; Bis, Joshua C.; Yaqub, Amber; Prokic, Ivana; Chapuis, Julien; Ahmad, Shahzad; Giedraitis, Vilmantas; Aarsland, Dag; Garcia-Gonzalez, Pablo; Abdelnour, Carla; Alarcón-Martín, Emilio; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Álvarez, Victoria; Armstrong, Nicola J.; Tsolaki, Anthoula; Antúnez, Carmen; Appollonio, Ildebrando; Arcaro, Marina; Archetti, Silvana; Pastor, Alfonso Arias; Arosio, Beatrice; Athanasiu, Lavinia; Bailly, Henri; Banaj, Nerisa; Baquero, Miquel; Barral, Sandra; Beiser, Alexa; Pastor, Ana Belén; Below, Jennifer E.; Benchek, Penelope; Benussi, Luisa; Berr, Claudine; Besse, Céline; Bessi, Valentina; Binetti, Giuliano; Bizarro, Alessandra; Blesa, Rafael; Boada, Mercè; Boerwinkle, Eric; Borroni, Barbara; Boschi, Silvia; Bossù, Paola; Bråthen, Geir; Bressler, Jan; Bresner, Catherine; Brodaty, Henry; Brookes, Keeley J.; Brusco, Luis Ignacio; Buiza-Rueda, Dolores; Bûrger, Katharina; Burholt, Vanessa; Bush, William S.; Calero, Miguel; Cantwell, Laura B.; Chene, Geneviève; Chung, Jaeyoon; Cuccaro, Michael L.; Carracedo, Ángel; Cecchetti, Roberta; Cervera-Carles, Laura; Charbonnier, Camille; Chen, Hung-Hsin; Chillotti, Caterina; Ciccone, Simona; Claassen, Jurgen A H R; Clark, Christopher; Conti, Elisa; Corma-Gómez, Anaïs; Costantini, Emanuele; Custodero, Carlo; Daian, Delphine; Dalmasso, Maria Carolina; Daniele, Antonio; Dardiotis, Efthimios; Dartigues, Jean-François; de Deyn, Peter Paul; de Paiva Lopes, Katia; de Witte, Lot D.; Debette, Stéphanie; Deckert, Jürgen; Del Ser, Teodoro; Denning, Nicola; DeStefano, Anita; Dichgans, Martin; Diehl-Schmid, Janine; Diez-Fairen, Mónica; Rossi, Paolo Dionigi; Djurovic, Srdjan; Duron, Emmanuelle; Düzel, Emrah; Dufouil, Carole; Eiriksdottir, Gudny; Engelborghs, Sebastiaan; Escott-Price, Valentina; Espinosa, Ana; Ewers, Michael; Faber, Kelley M.; Fabrizio, Tagliavini; Nielsen, Sune Fallgaard; Fardo, David W.; Farotti, Lucia; Fenoglio, Chiara; Fernández-Fuertes, Marta; Ferrari, Raffaele; Ferreira, Catarina B.; Ferri, Evelyn; Fin, Bertrand; Fischer, Peter; Fladby, Tormod; Fließbach, Klaus; Fongang, Bernard; Fornage, Myriam; Fortea, Juan; Foroud, Tatiana M.; Fostinelli, Silvia; Fox, Nick C.; Franco-Macías, Emlio; Bullido, María J; Frank-García, Ana; Froelich, Lutz; Fulton-Howard, Brian; Galimberti, Daniela; García-Alberca, Jose Maria; García-González, Pablo; Garcia-Madrona, Sebastian; Garcia-Ribas, Guillermo; Ghidoni, Roberta; Giegling, Ina; Giorgio, Giaccone; Goate, Alison M.; Goldhardt, Oliver; Gomez-Fonseca, Duber; González-Pérez, Antonio; Graff, Caroline; Grande, Giulia; Green, Emma; Grimmer, Timo; Grünblatt, Edna; Grunin, Michelle; Gudnason, Vilmundur; Guetta-Baranes, Tamar; Haapasalo, Annakaisa; Hadjigeorgiou, Georgios; Haines, Jonathan L.; Hamilton-Nelson, Kara L.; Hampel, Harald; Hanon, Olivier; Hardy, John; Hartmann, Annette M.; Hausner, Lucrezia; Harwood, Janet; Heilmann-Heimbach, Stefanie; Helisalmi, Seppo; Heneka, Michael T.; Hernández, Isabel; Herrmann, Martin J.; Hoffmann, Per; Holmes, Clive; Holstege, Henne; Vilas, Raquel Huerto; Hulsman, Marc; Humphrey, Jack; Biessels, Geert Jan; Jian, Xueqiu; Johansson, Charlotte; Jun, Gyungah R.; Kastumata, Yuriko; Kauwe, John; Kehoe, Patrick G.; Kilander, Lena; Ståhlbom, Anne Kinhult; Kivipelto, Miia; Koivisto, Anne; Kornhuber, Johannes; Kosmidis, Mary H.; Kukull, Walter A.; Kuksa, Pavel P.; Kunkle, Brian W.; Kuzma, Amanda B.; Lage, Carmen; Laukka, Erika J.; Launer, Lenore; Lauria, Alessandra; Lee, Chien-Yueh; Lehtisalo, Jenni; Lerch, Ondrej; Lleó, Alberto; Longstreth, William; Lopez, Oscar; de Munain, Adolfo Lopez; Love, Seth; Löwemark, Malin; Luckcuck, Lauren; Lunetta, Kathryn L.; Ma, Yiyi; Macías, Juan; MacLeod, Catherine A.; Maier, Wolfgang; Mangialasche, Francesca; Spallazzi, Marco; Marquié, Marta; Marshall, Rachel; Martin, Eden R.; Montes, Angel Martín; Rodríguez, Carmen Martínez; Masullo, Carlo; Mayeux, Richard; Mead, Simon; Mecocci, Patrizia; Medina, Miguel; Meggy, Alun; Mehrabian, Shima; Mendoza, Silvia; Menéndez-González, Manuel; Mir, Pablo; Moebus, Susanne; Mol, Merel; Molina-Porcel, Laura; Montrreal, Laura; Morelli, Laura; Moreno, Fermin; Morgan, Kevin; Mosley, Thomas; Nöthen, Markus M.; Muchnik, Carolina; Mukherjee, Shubhabrata; Nacmias, Benedetta; Ngandu, Tiia; Nicolas, Gael; Nordestgaard, Børge G; Olaso, Robert; Orellana, Adelina; Orsini, Michela; Ortega, Gemma; Padovani, Alessandro; Paolo, Caffarra; Papenberg, Goran; Parnetti, Lucilla; Pasquier, Florence; Pastor, Pau; Peloso, Gina; Pérez-Cordón, Alba; Pérez-Tur, Jordi; Pericard, Pierre; Peters, Oliver; Pijnenburg, Yolande A L; Pineda, Juan A.; Piñol-Ripoll, Gerard; Pisanu, Claudia; Polak, Thomas; Popp, Julius; Posthuma, Danielle; Priller, Josef; Puerta, Raquel; Quenez, Olivier; Quintela, Inés; Thomassen, Jesper Qvist; Rábano, Alberto; Rainero, Innocenzo; Rajabli, Farid; Ramakers, Inez; Real, Luis M.; Reinders, Marcel J T; Reitz, Christiane; Reyes-Dumeyer, Dolly; Ridge, Perry; Riedel-Heller, Steffi; Riederer, Peter; Roberto, Natalia; Rodriguez-Rodriguez, Eloy; Rongve, Arvid; Allende, Irene Rosas; Rosende-Roca, Maitée; Royo, Jose Luis; Rubino, Elisa; Rujescu, Dan; Sáez, María Eugenia; Sakka, Paraskevi; Saltvedt, Ingvild; Sanabria, Ángela; Sánchez-Arjona, María Bernal; Sanchez-Garcia, Florentino; Juan, Pascual Sánchez; Sánchez-Valle, Raquel; Sando, Sigrid Botne; Sarnowski, Chloé; Satizabal, Claudia L.; Scamosci, Michela; Scarmeas, Nikolaos; Scarpini, Elio; Scheltens, Philip; Scherbaum, Norbert; Scherer, Martin; Schmid, Matthias; Schneider, Anja; Schott, Jonathan M.; Selbæk, Geir; Seripa, Davide; Serrano, Manuel; Sha, Jin; Shadrin, Alexey; Skrobot, Olivia; Slifer, Susan; Snijders, Gijsje J L; Soininen, Hilkka; Solfrizzi, Vincenzo; Solomon, Alina; Song, Yeunjoo; Sorbi, Sandro; Sotolongo-Grau, Oscar; Spalletta, Gianfranco; Spottke, Annika; Squassina, Alessio; Stordal, Eystein; Tartan, Juan Pablo; Tárraga, Lluís; Tesí, Niccolo; Thalamuthu, Anbupalam; Thomas, Tegos; Tosto, Giuseppe; Traykov, Latchezar; Tremolizzo, Lucio; Tybjærg-Hansen, Anne; Uitterlinden, Andre; Ullgren, Abbe; Ulstein, Ingun; Valero, Sergi; Valladares, Otto; Broeckhoven, Christine Van; Vance, Jeffery; Vardarajan, Badri N.; van der Lugt, Aad; Dongen, Jasper Van; van Rooij, Jeroen; van Swieten, John; Vandenberghe, Rik; Verhey, Frans; Vidal, Jean-Sébastien; Vogelgsang, Jonathan; Vyhnalek, Martin; Wagner, Michael; Wallon, David; Wang, Li-San; Wang, Ruiqi; Weinhold, Leonie; Wiltfang, Jens; Windle, Gill; Woods, Bob; Yannakoulia, Mary; Zare, Habil; Zhao, Yi; Zhang, Xiaoling; Zhu, Congcong; Zulaica, Miren; Farrer, Lindsay A.; Psaty, Bruce M.; Ghanbari, Mohsen; Raj, Towfique; Sachdev, Perminder; Mather, Karen; Jessen, Frank; Ikram, M Arfan; de Mendonça, Alexandre; Hort, Jakub; Tsolaki, Magda; Pericak-Vance, Margaret A.; Amouyel, Philippe; Williams, Julie; Frikke-Schmidt, Ruth; Clarimon, Jordi; Deleuze, Jean-François; Rossi, Giacomina; Seshadri, Sudha; Andreassen, Ole; Ingelsson, Martin; Hiltunen, Mikko; Sleegers, Kristel; Schellenberg, Gerard D.; van Duijn, Cornelia M.; Sims, Rebecca; van der Flier, Wiesje M.; Ruiz, Agustín; Ramirez, Alfredo; Lambert, Jean-Charles
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Date
2022Metadata
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Abstract
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
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Nature ResearchJournal
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M.; Hantunen, Sari; Hao, Jie; Hardman, Carla Menêses; Kumar, Rachakulla Hari; Lassen, Tina Harmer; Harooni, Javad; Hashemi-Shahri, Seyed Mohammad; Hassapidou, Maria; Hata, Jun; Haugsgjerd, Teresa Risan; Hayes, Alison J.; He, Jiang; He, Yuan; He, Yuna; Heidinger-Felső, Regina; Heier, Margit; Hejgaard, Tatjana; Hendriks, Marleen Elisabeth; dos Santos Henrique, Rafael; Henriques, Ana; Cadena, Leticia Hernandez; Herrala, Sauli; Herrera-Cuenca, Marianella; Herrera, Victor M.; Herter-Aeberli, Isabelle; Herzig, Karl-Heinz; Heshmat, Ramin; Hill, Allan G.; Ho, Sai Yin; Ho, Suzanne C.; Hobbs, Michael; Höfelmann, Doroteia A.; Holdsworth, Michelle; Homayounfar, Reza; Homs, Clara; Hopman, Wilma M.; Horimoto, Andrea R. V. R.; Hormiga, Claudia M.; Horta, Bernardo L.; Houti, Leila; Howitt, Christina; Htay, Thein Thein; Htet, Aung Soe; Htike, Maung Maung Than; Hu, Yonghua; Huerta, José María; Huhtaniemi, Ilpo Tapani; Huiart, Laetitia; Petrescu, Constanta Huidumac; Huisman, Martijn; Husseini, Abdullatif; Huu, Chinh Nguyen; Huybrechts, Inge; Hwalla, Nahla; Hyska, Jolanda; Iacoviello, Licia; Iakupova, Ellina M.; Ibarluzea, Jesús M.; Ibrahim, Mohsen M.; Wong, Norazizah Ibrahim; Ikram, M. Arfan; Iñiguez, Carmen; Iotova, Violeta; Irazola, Vilma E.; Ishida, Takafumi; Isiguzo, Godsent C.; Islam, Muhammad; Islam, Sheikh Mohammed Shariful; Islek, Duygu; Ivanova-Pandourska, Ivaila Y.; Iwasaki, Masanori; Jääskeläinen, Tuija; Jackson, Rod T.; Jacobs, Jeremy M.; Jadoul, Michel; Jafar, Tazeen; Jallow, Bakary; James, Kenneth; Jamil, Kazi M.; Jamrozik, Konrad; Jansson, Anna; Janszky, Imre; Janus, Edward; Jarani, Juel; Jarvelin, Marjo-Riitta; Jasienska, Grazyna; Jelaković, Ana; Jelaković, Bojan; Jennings, Garry; Jiang, Chao Qiang; Jimenez, Ramon O.; Jöckel, Karl-Heinz; Joffres, Michel; Jokelainen, Jari J.; Jonas, Jost B.; Jonnagaddala, Jitendra; Jørgensen, Torben; Joshi, Pradeep; Josipović, Josipa; Joukar, Farahnaz; Jóźwiak, Jacek J.; Judge, Debra S.; Juolevi, Anne; Jurak, Gregor; Simina, Iulia Jurca; Juresa, Vesna; Kaaks, Rudolf; Kaducu, Felix O.; Kafatos, Anthony; Kaj, Mónika; Kajantie, Eero Olavi; Kakutia, Natia; Kállayová, Daniela; Kalmatayeva, Zhanna; Kalter-Leibovici, Ofra; Kameli, Yves; Kampmann, Freja B.; Kanala, Kodanda R.; Kannan, Srinivasan; Kapantais, Efthymios; Karaglani, Eva; Karakosta, Argyro; Kårhus, Line L.; Karki, Khem B.; Katchunga, Philippe B.; Katibeh, Marzieh; Katz, Joanne; Katzmarzyk, Peter T.; Kauhanen, Jussi; Kaur, Prabhdeep; Kavousi, Maryam; Kazakbaeva, Gyulli M.; Kaze, François F.; Ke, Calvin; Keil, Ulrich; Boker, Lital Keinan; Keinänen-Kiukaanniemi, Sirkka; Kelishadi, Roya; Kelleher, Cecily; Kemper, Han C. G.; Keramati, Maryam; Kerimkulova, Alina; Kersting, Mathilde; Key, Timothy; Khader, Yousef Saleh; Khaledifar, Arsalan; Khalili, Davood; Khaw, Kay-Tee; Kheiri, Bahareh; Kheradmand, Motahareh; Khosravi, Alireza; Khouw, Ilse M. S. L.; Kiechl-Kohlendorfer, Ursula; Kiechl, Sophia J.; Kiechl, Stefan; Killewo, Japhet; Kim, Hyeon Chang; Kim, Jeongseon; Kindblom, Jenny M.; Kingston, Andrew; Klakk, Heidi; Klimek, Magdalena; Klimont, Jeannette; Klumbiene, Jurate; Knoflach, Michael; Koirala, Bhawesh; Kolle, Elin; Kolsteren, Patrick; König, Jürgen; Korpelainen, Raija; Korrovits, Paul; Korzycka, Magdalena; Kos, Jelena; Koskinen, Seppo; Kouda, Katsuyasu; Kovács, Éva; Kovacs, Viktoria Anna; Kovalskys, Irina; Kowlessur, Sudhir; Koziel, Slawomir; Kratenova, Jana; Kratzer, Wolfgang; Kriaucioniene, Vilma; Kriemler, Susi; Kristensen, Peter Lund; Krizan, Helena; Kroker-Lobos, Maria F.; Krokstad, Steinar; Kromhout, Daan; Kruger, Herculina S.; Kruger, Ruan; Kryst, Łukasz; Kubinova, Ruzena; Kuciene, Renata; Kujala, Urho M.; Kujundzic, Enisa; Kulaga, Zbigniew; Kulimbet, Mukhtar; Kumar, R. Krishna; Kunešová, Marie; Kurjata, Pawel; Kusuma, Yadlapalli S.; Kutsenko, Vladimir; Kuulasmaa, Kari; Kyobutungi, Catherine; La, Quang Ngoc; Laamiri, Fatima Zahra; Lachat, Carl; Lackner, Karl J.; Laid, Youcef; Lall, Lachmie; Lam, Tai Hing; Jimenez, Maritza Landaeta; Landais, Edwige; Lanska, Vera; Lappas, Georg; Larijani, Bagher; Larissa, Simo Pone; Latt, Tint Swe; Laurenzi, Martino; Lauria, Laura; Lazo-Porras, Maria; Le Coroller, Gwenaëlle; Le Nguyen Bao, Khanh; Le Port, Agnès; Le, Tuyen D.; Lee, Jeannette; Lee, Jeonghee; Lee, Paul H.; Lehmann, Nils; Lehtimäki, Terho; Lemogoum, Daniel; Leskošek, Branimir; Leszczak, Justyna; Leth-Møller, Katja B.; Leung, Gabriel M.; Levitt, Naomi S.; Li, Yanping; Liivak, Merike; Lilly, Christa L.; Lim, Charlie; Lim, Wei-Yen; Lima-Costa, M. Fernanda; Lin, Hsien-Ho; Lin, Xu; Lin, Yi-Ting; Lind, Lars; Lingam, Vijaya; Linkohr, Birgit; Linneberg, Allan; Lissner, Lauren; Litwin, Mieczyslaw; Liu, Jing; Liu, Lijuan; Lo, Wei-Cheng; Loit, Helle-Mai; Long, Khuong Quynh; Abril, Guadalupe Longo; Lopes, Luis; Lopes, Marcus V. V.; Lopes, Oscar; Lopez-Garcia, Esther; Lopez, Tania; Lotufo, Paulo A.; Lozano, José Eugenio; Lukrafka, Janice L.; Luksiene, Dalia; Lundqvist, Annamari; Lunet, Nuno; Lunogelo, Charles; Lustigová, Michala; Łuszczki, Edyta; M’Buyamba-Kabangu, Jean-René; Ma, Guansheng; Ma, Xu; Machado-Coelho, George L. L.; Machado-Rodrigues, Aristides M.; Macia, Enguerran; Macieira, Luisa M.; Madar, Ahmed Ali; Madsen, Anja L.; Maestre, Gladys E.; Maggi, Stefania; Magliano, Dianna J.; Magnacca, Sara; Magriplis, Emmanuella; Mahasampath, Gowri; Maire, Bernard; Majer, Marjeta; Makdisse, Marcia; Mäki, Päivi; Malekzadeh, Fatemeh; Malekzadeh, Reza; Malhotra, Rahul; Rao, Kodavanti Mallikharjuna; Malyutina, Sofia K.; Maniego, Lynell V.; Manios, Yannis; Manix, Masimango Imani; Mann, Jim I.; Mansour-Ghanaei, Fariborz; Manyanga, Taru; Manzato, Enzo; Marcil, Anie; Margozzini, Paula; Mariño, Joany; Markaki, Anastasia; Markey, Oonagh; Ioannidou, Eliza Markidou; Marques-Vidal, Pedro; Marques, Larissa Pruner; Marrugat, Jaume; Martin-Prevel, Yves; Martin, Rosemarie; Martorell, Reynaldo; Martos, Eva; Maruszczak, Katharina; Marventano, Stefano; Masala, Giovanna; Mascarenhas, Luis P.; Masoodi, Shariq R.; Mathiesen, Ellisiv B.; Mathur, Prashant; Matijasevich, Alicia; Matłosz, Piotr; Matsha, Tandi E.; Matsudo, Victor; Mavrogianni, Christina; Mazur, Artur; Mbanya, Jean Claude N.; McFarlane, Shelly R.; McGarvey, Stephen T.; McKee, Martin; McLachlan, Stela; McLean, Rachael M.; McLean, Scott B.; McNairy, Margaret L.; McNulty, Breige A.; Benchekor, Sounnia Mediene; Medzioniene, Jurate; Mehdipour, Parinaz; Mehlig, Kirsten; Mehrparvar, Amir Houshang; Meirhaeghe, Aline; Meisfjord, Jørgen Rajan; Meisinger, Christa; Melgarejo, Jesus D.; Melkumova, Marina; Mello, João; Méndez, Fabián; Mendivil, Carlos O.; Menezes, Ana Maria B.; Menon, Geetha R.; Mensink, Gert B. M.; Menzano, Maria Teresa; Meshram, Indrapal I.; Meto, Diane T.; Mi, Jie; Michaelsen, Kim F.; Michels, Nathalie; Mikkel, Kairit; Miłkowska, Karolina; Miller, Jody C.; Milushkina, Olga; Minderico, Cláudia S.; Mini, G.K.; Miquel, Juan Francisco; Miranda, J. Jaime; Mirjalili, Mohammad Reza; Mirkopoulou, Daphne; Mirrakhimov, Erkin; Mišigoj-Duraković, Marjeta; Mistretta, Antonio; Mocanu, Veronica; Modesti, Pietro A.; Moghaddam, Sahar Saeedi; Mohajer, Bahram; Mohamed, Mostafa K.; Mohamed, Shukri F.; Mohammad, Kazem; Mohammadi, Mohammad Reza; Mohammadi, Zahra; Mohammadifard, Noushin; Mohammadpourhodki, Reza; Mohan, Viswanathan; Mohanna, Salim; Yusoff, Muhammad Fadhli Mohd; Mohebbi, Iraj; Mohebi, Farnam; Moitry, Marie; Møllehave, Line T.; Møller, Niels C.; Molnár, Dénes; Momenan, Amirabbas; Mondo, Charles K.; Montenegro Mendoza, Roger A.; Monterrubio-Flores, Eric; Monyeki, Kotsedi Daniel K.; Moon, Jin Soo; Moosazadeh, Mahmood; Mopa, Hermine T.; Moradpour, Farhad; Moreira, Leila B.; Morejon, Alain; Moreno, Luis A.; Morey, Francis; Morgan, Karen; Morin, Suzanne N.; Mortensen, Erik Lykke; Moschonis, George; Moslem, Alireza; Mossakowska, Malgorzata; Mostafa, Aya; Mostafavi, Seyed-Ali; Mota-Pinto, Anabela; Mota, Jorge; Motlagh, Mohammad Esmaeel; Motta, Jorge; Moura-dos-Santos, Marcos André; Movsesyan, Yeva; Msyamboza, Kelias P.; Mu, Thet Thet; Muc, Magdalena; Muca, Florian; Mugoša, Boban; Muiesan, Maria L.; Müller-Nurasyid, Martina; Münzel, Thomas; Mursu, Jaakko; Murtagh, Elaine M.; Musa, Kamarul Imran; Milanović, Sanja Musić; Musil, Vera; Musinguzi, Geofrey; Muyer, Muel Telo M. C.; Nabipour, Iraj; Naderimagham, Shohreh; Nagel, Gabriele; Najafi, Farid; Nakamura, Harunobu; Nalecz, Hanna; Námešná, Jana; Nang, Ei Ei K.; Nangia, Vinay B.; Nankap, Martin; Narake, Sameer; Nardone, Paola; Naseri, Take; Nauck, Matthias; Neal, William A.; Nejatizadeh, Azim; Nekkantti, Chandini; Nelis, Keiu; Nenko, Ilona; Neovius, Martin; Nervi, Flavio; Ng, Tze Pin; Nguyen, Chung T.; Nguyen, Nguyen D.; Nguyen, Quang Ngoc; Ni, Michael Y.; Nicolescu, Rodica; Nie, Peng; Nieto-Martínez, Ramfis E.; Nikitin, Yury P.; Ning, Guang; Ninomiya, Toshiharu; Nishi, Nobuo; Nishtar, Sania; Noale, Marianna; Noboa, Oscar A.; Nogueira, Helena; Nordendahl, Maria; Nordestgaard, Børge G.; Noto, Davide; Nowak-Szczepanska, Natalia; Nsour, Mohannad Al; Nuhoğlu, Irfan; Nunes, Baltazar; Nurk, Eha; Nuwaha, Fred; Nyirenda, Moffat; O’Neill, Terence W.; O’Reilly, Dermot; Obreja, Galina; Ochimana, Caleb; Ochoa-Avilés, Angélica M.; Oda, Eiji; Odili, Augustine N.; Oh, Kyungwon; Ohara, Kumiko; Ohlsson, Claes; Ohtsuka, Ryutaro; Olafsson, Örn; Olinto, Maria Teresa A.; Oliveira, Isabel O.; Omar, Mohd Azahadi; Omar, Saeed M.; Onat, Altan; Ong, Sok King; Onland-Moret, N. Charlotte; Ono, Lariane M.; Ordunez, Pedro; Ornelas, Rui; Ortiz, Ana P.; Ortiz, Pedro J.; Osler, Merete; Osmond, Clive; Ostojic, Sergej; Ostovar, Afshin; Otero, Johanna A.; Overvad, Kim; Owusu-Dabo, Ellis; Paccaud, Fred Michel; Pagkalos, Ioannis; Pahomova, Elena; de Paiva, Karina Mary; Pająk, Andrzej; Palloni, Alberto; Palmieri, Luigi; Pan, Wen-Harn; Panda-Jonas, Songhomitra; Pandey, Arvind; Panza, Francesco; Paoli, Mariela; Papadopoulou, Sousana K.; Papandreou, Dimitrios; Pareja, Rossina G.; Park, Soon-Woo; Park, Suyeon; Parnell, Winsome R.; Parsaeian, Mahboubeh; Pascanu, Ionela M.; Pasquet, Patrick; Patel, Nikhil D.; Pattussi, Marcos; Pavlyshyn, Halyna; Pechlaner, Raimund; Pećin, Ivan; Pednekar, Mangesh S.; Pedro, João M.; Peer, Nasheeta; Peixoto, Sergio Viana; Peltonen, Markku; Pereira, Alexandre C.; Peres, Marco A.; Pérez, Cynthia M.; Peterkova, Valentina; Peters, Annette; Petersmann, Astrid; Petkeviciene, Janina; Petrauskiene, Ausra; Kovtun, Olga Petrovna; Pettenuzzo, Emanuela; Peykari, Niloofar; Pfeiffer, Norbert; Phall, Modou Cheyassin; Pham, Son Thai; Pichardo, Rafael N.; Pierannunzio, Daniela; Pigeot, Iris; Pikhart, Hynek; Pilav, Aida; Pilotto, Lorenza; Pistelli, Francesco; Pitakaka, Freda; Piwonska, Aleksandra; Pizarro, Andreia N.; Plans-Rubió, Pedro; Platonova, Alina G.; Poh, Bee Koon; Pohlabeln, Hermann; Polka, Nadija S.; Pop, Raluca M.; Popovic, Stevo R.; Porta, Miquel; Posch, Georg; Poudyal, Anil; Poulimeneas, Dimitrios; Pouraram, Hamed; Pourfarzi, Farhad; Pourshams, Akram; Poustchi, Hossein; Pradeepa, Rajendra; Price, Alison J.; Price, Jacqueline F.; Prista, Antonio; Providencia, Rui; Puder, Jardena J.; Pudule, Iveta; Puiu, Maria; Punab, Margus; Qadir, Muhammed S.; Qasrawi, Radwan F.; Qorbani, Mostafa; Quintana, Hedley K.; Quiroga-Padilla, Pedro J.; Bao, Tran Quoc; Rach, Stefan; Radic, Ivana; Radisauskas, Ricardas; Rahimikazerooni, Salar; Rahman, Mahfuzar; Rahman, Mahmudur; Raitakari, Olli; Raj, Manu; Rajabov, Tamerlan; Rakhmatulloev, Sherali; Rakovac, Ivo; Rao, Sudha Ramachandra; Ramachandran, Ambady; Ramadan, Otim P. C.; Ramires, Virgílio V.; Ramke, Jacqueline; Ramos, Elisabete; Ramos, Rafel; Rampal, Lekhraj; Rampal, Sanjay; Rangelova, Lalka S.; Rarra, Vayia; Rascon-Pacheco, Ramon A.; Rech, Cassiano Ricardo; Redon, Josep; Reganit, Paul Ferdinand M.; Regecová, Valéria; Renner, Jane D. P.; Repasy, Judit A.; Reuter, Cézane P.; Revilla, Luis; Rezaianzadeh, Abbas; Rho, Yeunsook; Ribas-Barba, Lourdes; Ribeiro, Robespierre; Riboli, Elio; Richter, Adrian; Rigo, Fernando; Rigotti, Attilio; Rinaldo, Natascia; Rinke de Wit, Tobias F.; Rito, Ana I.; Ritti-Dias, Raphael M.; Rivera, Juan A.; Roa, Reina G.; Robinson, Louise; Robitaille, Cynthia; Roccaldo, Romana; Rodrigues, Daniela; Rodríguez-Artalejo, Fernando; del Cristo Rodriguez-Perez, María; Rodríguez-Villamizar, Laura A.; Rodríguez, Andrea Y.; Roggenbuck, Ulla; Rohloff, Peter; Rohner, Fabian; Rojas-Martinez, Rosalba; Rojroongwasinkul, Nipa; Romaguera, Dora; Romeo, Elisabetta L.; Rosario, Rafaela V.; Rosengren, Annika; Rouse, Ian; Rouzier, Vanessa; Roy, Joel G. R.; Ruano, Maira H.; Rubinstein, Adolfo; Rühli, Frank J.; Ruidavets, Jean-Bernard; Ruiz-Betancourt, Blanca Sandra; Ruiz-Castell, Maria; Moreno, Emma Ruiz; Rusakova, Iuliia A.; Jonsson, Kenisha Russell; Russo, Paola; Rust, Petra; Rutkowski, Marcin; Saamel, Marge; Sabanayagam, Charumathi; Sabbaghi, Hamideh; Sacchini, Elena; Sachdev, Harshpal S.; Sadjadi, Alireza; Safarpour, Ali Reza; Safi, Sare; Safiri, Saeid; Saghi, Mohammad Hossien; Saidi, Olfa; Saki, Nader; Šalaj, Sanja; Salanave, Benoit; Martinez, Eduardo Salazar; Saleva, Calogero; Salmerón, Diego; Salomaa, Veikko; Salonen, Jukka T.; Salvetti, Massimo; Samoutian, Margarita; Sánchez-Abanto, Jose; Rodríguez, Inés Sánchez; Sandjaja, NN; Sans, Susana; Marina, Loreto Santa; Santacruz, Ethel; Santos, Diana A.; Santos, Ina S.; Santos, Lèlita C.; Santos, Maria Paula; Santos, Osvaldo; Santos, Rute; Santos, Tamara R.; Saramies, Jouko L.; Sardinha, Luis B.; Sarrafzadegan, Nizal; Sathish, Thirunavukkarasu; Saum, Kai-Uwe; Savva, Savvas; Savy, Mathilde; Sawada, Norie; Sbaraini, Mariana; Scazufca, Marcia; Schaan, Beatriz D.; Rosario, Angelika Schaffrath; Schargrodsky, Herman; Schienkiewitz, Anja; Schindler, Karin; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Ida Maria; Schneider, Andrea; Schnohr, Peter; Schöttker, Ben; Schramm, Sara; Schramm, Stine; Schröder, Helmut; Schultsz, Constance; Schulze, Matthias B.; Schutte, Aletta E.; Sebert, Sylvain; Sedaghattalab, Moslem; Selamat, Rusidah; Sember, Vedrana; Sen, Abhijit; Senbanjo, Idowu O.; Sepanlou, Sadaf G.; Sequera, Guillermo; Serra-Majem, Luis; Servais, Jennifer; Ševčíková, Ľudmila; Shalnova, Svetlana; Shamah-Levy, Teresa; Shamshirgaran, Seyed Morteza; Shanthirani, Coimbatore Subramaniam; Sharafkhah, Maryam; Sharma, Sanjib K.; Shaw, Jonathan E.; Shayanrad, Amaneh; Shayesteh, Ali Akbar; Shengelia, Lela; Shi, Zumin; Shibuya, Kenji; Shimizu-Furusawa, Hana; Shimony, Tal; Shiri, Rahman; Shrestha, Namuna; Si-Ramlee, Khairil; Siani, Alfonso; Siantar, Rosalynn; Sibai, Abla M.; Sidossis, Labros S.; Silitrari, Natalia; Silva, Antonio M.; de Moura Silva, Caroline Ramos; Silva, Diego Augusto Santos; Silva, Kelly S.; Sim, Xueling; Simon, Mary; Simons, Judith; Simons, Leon A.; Sjöberg, Agneta; Sjöström, Michael; Skoblina, Natalia A.; Skodje, Gry Irene; Slazhnyova, Tatyana; Slowikowska-Hilczer, Jolanta; Slusarczyk, Przemysław; Smeeth, Liam; So, Hung-Kwan; Soares, Fernanda Cunha; Sobek, Grzegorz; Sobngwi, Eugène; Sodemann, Morten; Söderberg, Stefan; Soekatri, Moesijanti Y. E.; Soemantri, Agustinus; Sofat, Reecha; Solfrizzi, Vincenzo; Somi, Mohammad Hossein; Sonestedt, Emily; Song, Yi; Soofi, Sajid; Sørensen, Thorkild I. A.; Sørgjerd, Elin Pettersen; Jérome, Charles Sossa; Soto-Rojas, Victoria E.; Soumaré, Aïcha; Sousa-Poza, Alfonso; Sovic, Slavica; Sparboe-Nilsen, Bente; Sparrenberger, Karen; Spencer, Phoebe R.; Spinelli, Angela; Spiroski, Igor; Staessen, Jan A.; Stamm, Hanspeter; Staub, Kaspar; Stavreski, Bill; Steene-Johannessen, Jostein; Stehle, Peter; Stein, Aryeh D.; Stergiou, George S.; Stessman, Jochanan; Stevanović, Ranko; Stieber, Jutta; Stöckl, Doris; Stokwiszewski, Jakub; Stoyanova, Ekaterina; Stratton, Gareth; Stronks, Karien; Strufaldi, Maria Wany; Sturua, Lela; Suárez-Medina, Ramón; Suka, Machi; Sun, Chien-An; Sun, Liang; Sundström, Johan; Sung, Yn-Tz; Sunyer, Jordi; Suriyawongpaisal, Paibul; Sweis, Nabil William G.; Swinburn, Boyd A.; Sy, Rody G.; Sylva, René Charles; Szklo, Moyses; Szponar, Lucjan; Tabone, Lorraine; Tai, E. Shyong; Tambalis, Konstantinos D.; Tammesoo, Mari-Liis; Tamosiunas, Abdonas; Tan, Eng Joo; Tang, Xun; Tanrygulyyeva, Maya; Tanser, Frank; Tao, Yong; Tarawneh, Mohammed Rasoul; Tarp, Jakob; Tarqui-Mamani, Carolina B.; Braunerová, Radka Taxová; Taylor, Anne; Taylor, Julie; Tchibindat, Félicité; te Velde, Saskia J.; Tebar, William R.; Tell, Grethe S.; Tello, Tania; Tham, Yih Chung; Thankappan, K.R.; Theobald, Holger; Theodoridis, Xenophon; Thomas, Nihal; Thorand, Barbara; Thuesen, Betina H.; Tichá, Ľubica; Timmermans, Erik J.; Tjandrarini, Dwi H.; Tjonneland, Anne; Tolonen, Hanna K.; Tolstrup, Janne S.; Topbas, Murat; Topór-Mądry, Roman; Torheim, Liv Elin; Tormo, María José; Tornaritis, Michael J.; Torrent, Maties; Torres-Collado, Laura; Toselli, Stefania; Touloumi, Giota; Traissac, Pierre; Tran, Thi Tuyet-Hanh; Tremblay, Mark S.; Triantafyllou, Areti; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Trinh, Oanh T. H.; Trivedi, Atul; Tsao, Yu-Hsiang; Tshepo, Lechaba; Tsigga, Maria; Tsintavis, Panagiotis; Tsugane, Shoichiro; Tuitele, John; Tuliakova, Azaliia M.; Tulloch-Reid, Marshall K.; Tullu, Fikru; Tuomainen, Tomi-Pekka; Tuomilehto, Jaakko; Turley, Maria L.; Twig, Gilad; Tynelius, Per; Tzala, Evangelia; Tzotzas, Themistoklis; Tzourio, Christophe; Ueda, Peter; Ugel, Eunice; Ukoli, Flora A. M.; Ulmer, Hanno; Unal, Belgin; Usupova, Zhamyila; Uusitalo, Hannu M. T.; Uysal, Nalan; Vaitkeviciute, Justina; Valdivia, Gonzalo; Vale, Susana; Valvi, Damaskini; van Dam, Rob M.; van den Born, Bert-Jan; Van der Heyden, Johan; van der Schouw, Yvonne T.; Van Herck, Koen; Van Lippevelde, Wendy; Van Minh, Hoang; Van Schoor, Natasja M.; van Valkengoed, Irene G. M.; Vanderschueren, Dirk; Vanuzzo, Diego; Varbo, Anette; Varela-Moreiras, Gregorio; Vargas, Luz Nayibe; Varona-Pérez, Patricia; Vasan, Senthil K.; Vasques, Daniel G.; Vega, Tomas; Veidebaum, Toomas; Velasquez-Melendez, Gustavo; Velika, Biruta; Verloigne, Maïté; Veronesi, Giovanni; Verschuren, W. M. Monique; Victora, Cesar G.; Viegi, Giovanni; Viet, Lucie; Vik, Frøydis Nordgård; Vilar, Monica; Villalpando, Salvador; Vioque, Jesus; Virtanen, Jyrki K.; Visvikis-Siest, Sophie; Viswanathan, Bharathi; Vladulescu, Mihaela; Vlasoff, Tiina; Vocanec, Dorja; Vollenweider, Peter; Völzke, Henry; Voutilainen, Ari; Vrijheid, Martine; Vrijkotte, Tanja G. M.; Wade, Alisha N.; Waldhör, Thomas; Walton, Janette; Wambiya, Elvis O. A.; Bebakar, Wan Mohamad Wan; Mohamud, Wan Nazaimoon Wan; de Souza Wanderley Júnior, Rildo; Wang, Ming-Dong; Wang, Ningli; Wang, Qian; Wang, Xiangjun; Wang, Ya Xing; Wang, Ying-Wei; Wannamethee, S. Goya; Wareham, Nicholas; Weber, Adelheid; Webster-Kerr, Karen; Wedderkopp, Niels; Weghuber, Daniel; Wei, Wenbin; Weres, Aneta; Werner, Bo; Westbury, Leo D.; Whincup, Peter H.; Wickramasinghe, Kremlin; Widhalm, Kurt; Widyahening, Indah S.; Więcek, Andrzej; Wild, Philipp S.; Wilks, Rainford J.; Willeit, Johann; Willeit, Peter; Williams, Julianne; Wilsgaard, Tom; Wojciech, Rusek; Wojtyniak, Bogdan; Wolf, Kathrin; Wong-McClure, Roy A.; Wong, Andrew; Wong, Emily B.; Wong, Jyh Eiin; Wong, Tien Yin; Woo, Jean; Woodward, Mark; Wu, Frederick C.; Wu, Hon-Yen; Wu, Jianfeng; Wu, Li Juan; Wu, Shouling; Wyszyńska, Justyna; Xu, Haiquan; Xu, Liang; Yaacob, Nor Azwany; Yamborisut, Uruwan; Yan, Weili; Yang, Ling; Yang, Xiaoguang; Yang, Yang; Yardim, Nazan; Yasuharu, Tabara; García, Martha Yépez; Yiallouros, Panayiotis K.; Yngve, Agneta; Yoosefi, Moein; Yoshihara, Akihiro; You, Qi Sheng; You, San-Lin; Younger-Coleman, Novie O.; Yu, Yu-Ling; Yu, Yunjiang; Yusof, Safiah Md; Yusoff, Ahmad Faudzi; Zaccagni, Luciana; Zafiropulos, Vassilis; Zainuddin, Ahmad A.; Zakavi, Seyed Rasoul; Zamani, Farhad; Zambon, Sabina; Zampelas, Antonis; Zamrazilová, Hana; Zapata, Maria Elisa; Zargar, Abdul Hamid; Zaw, Ko Ko; Zayed, Ayman A.; Zdrojewski, Tomasz; Żegleń, Magdalena; Zejglicova, Kristyna; Vrkic, Tajana Zeljkovic; Zeng, Yi; Zhang, Luxia; Zhang, Zhen-Yu; Zhao, Dong; Zhao, Ming-Hui; Zhao, Wenhua; Zhecheva, Yanitsa V.; Zhen, Shiqi; Zheng, Wei; Zheng, Yingfeng; Zholdin, Bekbolat; Zhou, Maigeng; Zhu, Dan; Zins, Marie; Zitt, Emanuel; Zocalo, Yanina; Zoghlami, Nada; Cisneros, Julio Zuñiga; Zuziak, Monika; Bhutta, Zulfiqar A.; Black, Robert E.; Ezzati, Majid (Peer reviewed; Journal article, 2023)Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1,2,3,4,5,6. Here we used data from 2,325 population-based studies, with measurements of height and weight from ... -
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
Ezzati, Majid; Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Danaei, Goodarz; Hajifathalian, Kaveh; Taddei, Cristina; Carrillo-Larco, Rodrigo M; Djalalinia, Shirin; Khatibzadeh, Shahab; Lugero, Charles; Peykari, Niloofar; Zhang, Wan Zhu; Bennett, James; Bilano, Ver; Stevens, Gretchen A; Cowan, Melanie J; Riley, Leanne M; Chen, Zhengming; Hambleton, Ian R; Jackson, Rod T; Kengne, Andre Pascal; Khang, Young-Ho; Laxmaiah, Avula; Liu, Jing; Malekzadeh, Reza; Neuhauser, Hannelore K; Sorić, Maroje; Starc, Gregor; Sundström, Johan; Woodward, Mark; Abarca-Gómez, Leandra; Abdeen, Ziad A; Abu-Rmeileh, Niveen M; Acosta-Cazares, Benjamin; Adams, Robert J; Aekplakorn, Wichai; Afsana, Kaosar; Aguilar-Salinas, Carlos A; Agyemang, Charles; Ahmad, Noor Ani; Ahmadvand, Alireza; Ahrens, Wolfgang; Ajlouni, Kamel; Akhtaeva, Nazgul; Al-Raddadi, Rajaa; Ali, Mohamed M; Ali, Osman; Alkerwi, Ala'a; Aly, Eman; Amarapurkar, Deepak N; Amouyel, Philippe; Amuzu, Antoinette; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ängquist, Lars H; Anjana, Ranjit Mohan; Ansong, Daniel; Aounallah-Skhiri, Hajer; Araujo, Joana; Ariansen, Inger; Aris, Tahir; Arlappa, Nimmathota; Arveiler, Dominique; Aryal, Krishna K; Aspelund, Thor; Assah, Felix K; Assunção, Maria Cecília Formoso; Avdicova, Macria; Azevedo, Ana; Azizi, Fereidoun; Babu, Bontha V; Bahijri, Suhad; Balakrishna, Nagalla; Bamoshmoosh, Mohamed; Banach, Maciej; Bandosz, Piotr; Banegas, Jose R; Barbagallo, Carlo M; Barceló, Alberto; Barkat, Amina; Barros, Aluisio JD; Barros, Mauro V; Bata, Iqbal; Batieha, Anwar M; Batyrbek, Assembekov; Baur, Louise A; Beaglehole, Robert; Romdhane, Habiba Ben; Benet, Mikhail; Benson, Lowell S; Bernabe-Ortiz, Antonio; Bernotiene, Gailute; Bettiol, Heloisa; Bhagyalaxmi, Aroor; Bharadwaj, Sumit; Bhargava, Santosh K; Bi, Yufang; Bikbov, Mukharram; Bista, Bihungum; Bjerregaard, Peter; Bjertness, Espen; Bjertness, Marius Bergsmark; Björkelund, Cecilia; Blokstra, Anneke; Bo, Simona; Bobak, Martin; Boeing, Heiner; Boggia, Jose G; Boissonnet, Carlos P; Bongard, Vanina; Borchini, Rossana; Bovet, Pascal; Braeckman, Lutgart; Brajkovich, Imperia; Branca, Francesco; Breckenkamp, Juergen; Brenner, Hermann; Brewster, Lizzy M; Bruno, Graziella; Bueno-De-Mesquita, Hendrik Bastiaan; Bugge, Anna; Burns, Con; Bursztyn, Michael; de Léon, Antonio Cabrera; Cacciottolo, Joseph; Cai, Hui; Cameron, Christine; Can, Gunay; Candido, Ana Paula C; Capuano, Vincenzo; Cardoso, Viviane C; Carlsson, Axel C; Carvalho, Maria J; Casanueva, Felipe F; Casas, Juan-Pablo; Caserta, Carmelo A; Chamukuttan, Snehalatha; Chan, Angelique W; Chan, Queenie; Chaturvedi, Himanshu K; Chaturvedi, Nishi; Chen, Chien-Jen; Chen, Fangfang; Chen, Huashuai; Chen, Shuohua; Cheng, Ching-Yu; Dekkaki, Imane Cherkaoui; Chetrit, Angela; Chiolero, Arnaud; Chiou, Shu-Ti; Chirita-Emandi, Adela; Chirlaque, Maria-Dolores; Cho, Belong; Cho, Yumi; Christofaro, Diego G; Chudek, Jerzy; Cifkova, Renata; Cinteza, Eliza; Claessens, Frank; Clays, Els; Concin, Hans; Cooper, Cyrus; Cooper, Rachel; Coppinger, Tara C; Costanzo, Simona; Cottel, Dominique; Cowell, Chris; Craig, Cora L; Crujeiras, Ana B; Cruz, Juan J; D'Arrigo, Graziella; d'Orsi, Eleonora; Dallongeville, Jean; Damasceno, Albertino; Dankner, Rachel; Dantoft, Thomas M; Dauchet, Luc; Davletov, Kairat; De Backer, Guy; De Bacquer, Dirk; de Gaetano, Giovanni; De Henauw, Stefaan; de Oliveira, Paula Duarte; De Smedt, Delphine; Deepa, Mohan; Dehghan, Abbas; Delisle, Helene; Deschamps, Valerie; Dhana, Klodian; Di Castelnuovo, Augusto F; Dias-da-Costa, Juvenal Soares; Diaz, Alejandro; Dickerson, Ty T; Do, Ha TP; Dobson, Annette J; Donfrancesco, Chiara; Donoso, Silvana P; Doring, Angela; Dorobantu, Maria; Doua, Kouamelan; Drygas, Wojciech; Dulskiene, Virginija; Dzakula, Aleksandar; Dzerve, Vilnis; Dziankowska-Zaborszczyk, Elzbieta; Eggertsen, Robert; Ekelund, Ulf; El Ati, Jalila; Elliott, Paul; Elosua, Roberto; Erasmus, Rajiv T; Erem, Cihangir; Eriksen, Louise; Eriksson, Johan G; Escobedo-de la Peña, Jorge; Evans, Alun; Faeh, David; Fall, Caroline H; Farzadfar, Farshad; Felix-Redondo, Francisco J; Ferguson, Trevor S; Fernandes, Romulo A; Fernandez-Berges, Daniel; Ferrante, Daniel; Ferrari, Marika; Ferreccio, Catterina; Ferrieres, Jean; Finn, Joseph D; Fischer, Krista; Foger, Bernhard; Foo, Leng Huat; Forslund, Ann-Sofie; Forsner, Maria; Fouad, Heba M; Francis, Damian K; Franco, Maria do Carmo; Franco, Oscar H; Frontera, Guillermo; Fuchs, Flavio D; Fuchs, Sandra C; Fujita, Yuki; Furusawa, Takuro; Gaciong, Zbigniew; Galvano, Fabio; Garcia-de-la-Hera, Manoli; Gareta, Dickman; Garnett, Sarah P; Gaspoz, Jean-Michel; Gasull, Magda; Gates, Louise; Geleijnse, Johanna M; Ghasemian, Anoosheh; Ghimire, Anup; Giampaoli, Simona; Gianfagna, Francesco; Gill, Tiffany K; Giovannelli, Jonathan; Goldsmith, Rebecca A; Gonçalves, Helen; Gonzalez-Gross, Marcela; González-Rivas, Juan P; Gorbea, Mariano Bonet; Gottrand, Frederic; Graff-Iversen, Sidsel; Grafnetter, Dusan; Grajda, Aneta; Grammatikopoulou, Maria G; Gregor, Ronald D; Grodzicki, Tomasz; Grøntved, Anders; Grosso, Giuseppe; Gruden, Gabriella; Grujic, Vera; Gu, Dongfeng; Guan, Ong Peng; Gudmundsson, Elias F; Gudnason, Vilmundur; Guerrero, Ramiro; Guessous, Idris; Guimaraes, Andre L; Gulliford, Martin C; Gunnlaugsdóttir, Johanna; Gunter, Marc; Gupta, Prakash C; Gupta, Rajeev; Gureje, Oye; Gurzkowska, Beata; Gutierrez, Laura; Gutzwiller, Felix; Hadaegh, Farzad; Halkjær, Jytte; Hardy, Rebecca; Kumar, Rachakulla Hari; Hata, Jun; Hayes, Alison J; He, Jiang; He, Yuna; Hendriks, Marleen Elisabeth; Henriques, Ana; Cadena, Leticia Hernandez; Herrala, Sauli; Heshmat, Ramin; Hihtaniemi, Ilpo Tapani; Ho, Sai Yin; Ho, Suzanne C; Hobbs, Michael; Hofman, Albert; Dinc, Gonul Horasan; Horimoto, Andrea RVR; Hormiga, Claudia M; Horta, Bernardo L; Houti, Leila; Howitt, Christina; Htay, Thein Thein; Htet, Aung Soe; Htike, Maung Maung Than; Hu, Yonghua; Huerta, José María; Huisman, Martijn; Husseini, Abdullatif S; Huybrechts, Inge; Hwalla, Nahla; Iacoviello, Licia; Iannone, Anna G; Ibrahim, Mohsen M; Wong, Norazizah Ibrahim; Ikeda, Nayu; Ikram, M Arfan; Irazola, Vilma E; Islam, Muhammad; al-Safi Ismail, Aziz; Ivkovic, Vanja; Iwasaki, Masanori; Jacobs, Jeremy M; Jaddou, Hashem; Jafar, Tazeen; Jamrozik, Konrad; Janszky, Imre; Jasienska, Grazyna; Jóźwiak, Ana; Jelakovic, Bojan; Jennings, Garry; Jeong, Seung-Lyeal; Jiang, Chao Qiang; Joffres, Michel; Johansson, Mattias; Jokelainen, Jari J; Jonas, Jost B; Jørgensen, Torben; Joshi, Pradeep; Jóźwiak, Jacek Jerzy; Juolevi, Anne; Jurak, Gregor; Juresa, Vesna; Kaaks, Rudolf; Kafatos, Anthony; Kajantie, Eero O; Kalter-Leibovici, Ofra; Kamaruddin, Nor Azmi; Karki, Khem B; Kasaeian, Amir; Katz, Joanne; Kauhanen, Jussi; Kaur, Prabhdeep; Kavousi, Maryam; Kazakbaeva, Gyulli; Keil, Ulrich; Boker, Lital Keinan; Keinänen-Kiukaanniemi, Sirkka; Kelishadi, Roya; Kemper, Han CG; Kengne, Andre P; Kerimkulova, Alina; Kersting, Mathilde; Key, Timothy; Khader, Yousef Saleh; Khalili, Davood; Khateeb, Mohammad; Khaw, Kay-Tee; Kiechl-Kohlendorfer, Ursula; Kiechl, Stefan; Killewo, Japhet; Kim, Jeongseon; Kim, Yeon-Yong; Klumbiene, Jurate; Knoflach, Michael; Kolle, Elin; Kolsteren, Patrick; Korrovits, Paul; Koskinen, Seppo; Kouda, Katsuyasu; Kowlessur, Sudhir; Koziel, Slawomir; Kriemler, Susi; Kristensen, Peter Lund; Krokstad, Steinar; Kromhout, Daan; Kruger, Herculina S; Kubinova, Ruzena; Kuciene, Renata; Kuh, Diana; Kujala, Urho M; Kulaga, Zbigniew; Kumar, R Krishna; Kurjata, Pawel; Kusuma, Yadlapalli S; Kuulasmaa, Kari; Kyobutungi, Catherine; Laatikainen, Tiina; Lachat, Carl; Lam, Tai Hing; Landrove, Orlando; Lanska, Vera; Lappas, Georg; Larijani, Bagher; Laugsand, Lars Erik; Bao, Khanh Le Nguyen; Le, Tuyen D; Leclercq, Catherine; Lee, Jeannette; Lee, Jeonghee; Lehtimäki, Terho; Leon-Munoz, Luz M; Levitt, Naomi S; Li, Yanping; Lilly, Christa L; Lim, Wei-Yen; Lima-Costa, M Fernanda; Lin, Hsien-Ho; Lin, Xu; Lind, Lars; Linneberg, Allan; Lissner, Lauren; Litwin, Mieczyslaw; Lorbeer, Roberto; Lotufo, Paulo A; Lozano, Jose Eugenio; Luksiene, Dalia; Lundqvist, Annamari; Lunet, Nuno; Lytsy, Per; Ma, Guansheng; Ma, Jun; Machado-Coelho, George LL; Machi, Suka; Maggi, Stefania; Magliano, Dianna J; Magriplis, Emmanuella; Majer, Marjeta; Makdisse, Marcia; Malhotra, Rahul; Rao, Kodavanti Mallikharjuna; Malyutina, Sofia; Manios, Yannis; Mann, Jim I; Manzato, Enzo; Margozzini, Paula; Marques-Vidal, Pedro; Marques, Larissa Pruner; Marrugat, Jaume; Martorell, Reynaldo; Mathiesen, Ellisiv B.; Matijasevich, Alicia; Matsha, Tandi E; Mbanya, Jean Claude N; Posso, Anselmo J Mc Donald; McFarlane, Shelly R; McGarvey, Stephen T; McLachlan, Stela; McLean, Rachael M; McLean, Scott B; McNulty, Breige A; Mediene-Benchekor, Sounnia; Medzioniene, Jurate; Meirhaeghe, Aline; Meisinger, Christa; Menezes, Ana Maria B; Menon, Geetha R; Meshram, Indrapal I; Metspalu, Andres; Meyer, Haakon E; Mi, Jie; Mikkel, Kairit; Miller, Jody C; Minderico, Claudia S; Miquel, Juan Francisco; Miranda, J Jaime; Mirrakhimov, Erkin; Misigoj-Durakovic, Marjeta; Modesti, Pietro A; Mohamed, Mostafa K; Mohammad, Kazem; Mohammadifard, Noushin; Mohan, Viswanathan; Mohanna, Salim; Yusoff, Muhammad Fadhli Mohd; Møllehave, Line Tang; Møller, Niels C; Molnar, Denes; Momenan, Amirabbas; Mondo, Charles K; Monyeki, Kotsedi Daniel K; Moon, Jin Soo; Moreira, Leila B; Morejon, Alain; Moreno, Luis A; Morgan, Karen; Moschonis, George; Mossakowska, Malgorzata; Mostafa, Aya; Mota, Jorge; Motlagh, Mohammad Esmaeel; Motta, Jorge; Msyamboza, Kelias P; ThetMu, Thet; Muiesan, Maria L; Muller-Nurasyid, Martina; Murphy, Neil; Mursu, Jaakko; Musil, Vera; Nabipour, Iraj; Nagel, Gabriele; Naidu, Balkish M; Nakamura, Harunobu; Námešná, Jana; Nang, Ei Ei K; Nangia, Vinay B; Narake, Sameer; Nauck, Matthias; Navarrete-Muñoz, Eva María; Ndiaye, Ndeye Coumba; Neal, William A; Nenko, Ilona; Neovius, Martin; Nervi, Flavio; Nguyen, Chung T; Nguyen, Nguyen D; Nguyen, Quang Ngoc; Nguyen, Quang V; Nieto-Martinez, Ramfis E; Niiranen, Teemu J; Ning, Guang; Ninomiya, Toshiharu; Nishtar, Sania; Noale, Marianna; Noboa, Oscar A; Noorbala, Ahmad Ali; Norat, Teresa; Noto, Davide; Al Nsour, Mohannad; O'Reilly, Dermot; Oda, Eiji; Oehlers, Glenn; Oh, Kyungwon; Ohara, Kumiko; Olinto, Maria Teresa A; Oliveira, Isabel O; Omar, Mohd Azahadi; Onat, Altan; Ong, Sok King; Ono, Lariane M; Ordunez, Pedro; Ornelas, Rui; Osmond, Clive; Ostojic, Sergej M; Ostovar, Afshin; Otero, Johanna A; Overvad, Kim; Owusu-Dabo, Ellis; Paccaud, Fred Michel; Padez, Cristina; Pahomova, Elena; Pajak, Andrzej; Palli, Domenico; Palmieri, Luigi; Pan, Wen-Harn; Panda-Jonas, Songhomitra; Panza, Francesco; Papandreou, Dimitrios; Park, Soon-Woo; Parnell, Winsome R; Parsaeian, Mahboubeh; Patel, Nikhil D; Pecin, Ivan; Pednekar, Mangesh S; Peer, Nasheeta; Peeters, Petra H; Peixoto, Sergio Viana; Peltonen, Markku; Pereira, Alexandre C; Peters, Annette; Petersmann, Astrid; Petkeviciene, Janina; Pham, Son Thai; Pigeot, Iris; Pikhart, Hynek; Pilav, Aida; Pilotto, Lorenza; Pitakaka, Freda; Piwonska, Aleksandra; Plans-Rubió, Pedro; Polašek, Ozren; Porta, Miquel; Portegies, Marileen LP; Pourshams, Akram; Poustchi, Hossein; Pradeepa, Rajendra; Prashant, Mathur; Price, Jacqueline F; Puder, Jardena J; Puiu, Maria; Punab, Margus; Qasrawi, Radwan F; Qorbani, Mostafa; Bao, Tran Quoc; Radic, Ivana; Radisauskas, Ricardas; Rahman, Mahfuzar; Raitakari, Olli; Raj, Manu; Rao, Sudha Ramachandra; Ramachandran, Ambady; Ramos, Elisabete; Rampal, Lekhraj; Rampal, Sanjay; Rangel Reina, Daniel A; Redon, Josep; Reganit, Paul Ferdinand M; Ribeiro, Robespierre; Riboli, Elio; Rigo, Fernando; Rinke de Wit, Tobias F; Ritti-Dias, Raphael M; Robinson, Sian M; Robitaille, Cynthia; Rodriguez-Artalejo, Fernando; Rodriguez-Perez, Maria del Cristo; Rodriguez-Villamizar, Laura A; Rojas-Martinez, Rosalba; Romaguera, Dora; Ronkainen, Kimmo; Rosengren, Annika; Roy, Joel GR; Rubinstein, Adolfo; Ruiz-Betancourt, Blanca Sandra; Rutkowski, Marcin; Sabanayagam, Charumathi; Sachdev, Harshpal S; Saidi, Olfa; Sakarya, Sibel; Salanave, Benoit; Martinez, Eduardo Salazar; Salmerón, Diego; Salomaa, Veikko; Salonen, Jukka T; Salvetti, Massimo; Sánchez-Abanto, José; Sans, Susana; Santos, Diana A; Santos, Ina S; Santos, Renata Nunes dos; Santos, Rute; Saramies, Jouko L; Sardinha, Luis B; Sarganas, Giselle; Sarrafzadegan, Nizal; Saum, Kai-Uwe; Savva, Savvas; Scazufca, Marcia; Schargrodsky, Herman; Schipf, Sabine; Schmidt, Carsten O; Schöttker, Ben; Schultsz, Constance; Schutte, Aletta E; Sein, Aye Aye; Sen, Abhijit; Senbanjo, Idowu O; Sepanlou, Sadaf G; Sharma, Sanjib K; Shaw, Jonathan E; Shibuya, Kenji; Shin, Dong Wook; Shin, Youchan; Si-Ramlee, Khairil; Siantar, Rosalynn; Sibai, Abla M; Silva, Diego Augusto Santos; Simon, Mary; Simons, Judith; Simons, Leon A; Sjöström, Michael; Skovbjerg, Sine; Slowikowska-Hilczer, Jolanta; Slusarczyk, Przemyslaw; Smeeth, Liam; Smith, Margaret C; Snijder, Marieke B; So, Hung-Kwan; Sobngwi, Eugene; Soderberg, Stefan; Solfrizzi, Vincenzo; Sonestedt, Emily; Song, Yi; Sørensen, Thorkild IA; Soric, Maroje; Jérome, Charles Sossa; Soumare, Aicha; Staessen, Jan A; Stathopoulou, Maria G; Stavreski, Bill; Steene-Johannessen, Jostein; Stehle, Peter; Stein, Aryeh D; Stergiou, George S; Stessman, Jochanan; Stieber, Jutta; Stöckl, Doris; Stocks, Tanja; Stokwiszewski, Jakub; Stronks, Karien; Strufaldi, Maria Wany; Sun, Chien-An; Sung, Yn-Tz; Suriyawongpaisal, Paibul; Sy, Rody G; Tai, E Shyong; Tammesoo, Mari-Liis; Tamosiunas, Abdonas; Tan, Eng Joo; Tang, Xun; Tanser, Frank; Tao, Yong; Tarawneh, Mohammed Rasoul; Tarqui-Mamani, Carolina B; Tautu, Oana-Florentina; Taylor, Anne; Theobald, Holger; Theodoridis, Xenophon; Thijs, Lutgarde; Thuesen, Betina H; Tjønneland, Anne; Tolonen, Hanna K; Tolstrup, Janne S; Topbas, Murat; Tópor-Madry, Roman; Tormo, Maria Jose; Torrent, Maties; Traissac, Pierre; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Trinh, Oanh TH; Trivedi, Atul; Tshepo, Lechaba; Tulloch-Reid, Marshall K; Tullu, Fikru; Tuomainen, Tomi-Pekka; Tuomilehto, Jaakko; Turley, Maria L; Tynelius, Per; Tzourio, Christophe; Ueda, Peter; Ugel, Eunice E; Ulmer, Hanno; Uusitalo, Hannu MT; Valdivia, Gonzalo; Valvi, Damaskini; van der Schouw, Yvonne T; Van Herck, Koen; Van Minh, Hoang; van Rossem, Lenie; Van Schoor, Natasja M; van Valkengoed, Irene GM; Vanderschueren, Dirk; Vanuzzo, Diego; Vatten, Lars Johan; Vega, Tomas; Velasquez-Melendez, Gustavo; Veronesi, Giovanni; Verschuren, WM Monique; Verstraeten, Roosmarijn; Victora, Cesar G; Viet, Lucie; Viikari-Juntura, Eira; Vineis, Paolo; Vioque, Jesus; Virtanen, Jyrki K; Visvikis-Siest, Sophie; Viswanathan, Bharathi; Vlasoff, Tiina; Vollenweider, Peter; Voutilainen, Sari; Wade, Alisha N; Wagner, Aline; Walton, Janette; Wan Bebakar, Wan Mohamad; Wan Mohamud, Wan Nazaimoon; Wanderley, Rildo S; Wang, Ming-Dong; Wang, Qian; Wang, Ya Xing; Wang, Ying-Wei; Wannamethee, S Goya; Wareham, Nicholas; Wedderkopp, Niels; Weerasekera, Deepa; Whincup, Peter H; Widhalm, Kurt; Widyahening, Indah S; Wiecek, Andrzej; Wijga, Alet H; Wilks, Rainford J; Willeit, Johann; Willeit, Peter; Williams, Emmanuel A; Wilsgaard, Tom; Wojtyniak, Bogdan; Wong-McClure, Roy A; Wong, Justin YY; Wong, Tien Yin; Woo, Jean; Wu, Aleksander Giwercman; Wu, Frederick C; Wu, Shouling; Xu, Haiquan; Yan, Weili; Yang, Xiaoguang; Ye, Xingwang; Yiallouros, Panayiotis K; Yoshihara, Akihiro; Younger-Coleman, Novie O; Yusoff, Ahmad Faudzi; Zainuddin, Ahmad Ali; Zambon, Sabina; Zampelas, Antonis; Zdrojewski, Tomasz; Zeng, Yi; Zhao, Dong; Zhao, Wenhua; Zheng, Wei; Zheng, Yingfeng; Zhu, Dan; Zhussupov, Baurzhan; Zimmermann, Esther; Cisneros, Julio Zuñiga (Journal article; Peer reviewed, 2018)Background Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) ... -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, Cristian; Teumer, Alexander; Gorski, Mathias; Chu, Audrey Y.; Li, Man; Mijatovic, Vladan; Garnaas, Maija; Tin, Adrienne; Sorice, Rossella; Li, Yong; Taliun, Daniel; Olden, Matthias; Foster, Meredith; Yang, Qiong; Chen, Ming-Huei; Pers, Tune H.; Johnson, Andrew D.; Ko, Yi-An; Fuchsberger, Christian; Tayo, Bamidele; Nalls, Michael; Feitosa, Mary F.; Isaacs, Aaron; Dehghan, Abbas; D'Adamo, Pio; Adeyemo, Adebowale; Dieffenbach, Aida Karina; Zonderman, Alan B.; Nolte, Ilja M.; van der Most, Peter J.; Wright, Alan F.; Shuldiner, Alan R.; Morrison, Alanna C.; Hofman, Albert; Smith, Albert V.; Dreisbach, Albert W.; Franke, Andre; Uitterlinden, André G.; Metspalu, Andres; Tonjes, Anke; Lupo, Antonio; Robino, Antonietta; Johansson, Åsa; Demirkan, Ayse; Kollerits, Barbara; Freedman, Barry I.; Ponte, Belen; Oostra, Ben A.; Paulweber, Bernhard; Krämer, Bernhard K.; Mitchell, Braxton D.; Buckley, Brendan M.; Peralta, Carmen A.; Hayward, Caroline; Helmer, Catherine; Rotimi, Charles N.; Shaffer, Christian M.; Müller, Christian; Sala, Cinzia; Van Duijn, Cornelia M.; Saint-Pierre, Aude; Ackermann, Daniel; Shriner, Daniel; Ruggiero, Daniela; Toniolo, Daniela; Lu, Yingchang; Cusi, Daniele; Czamara, Darina; Ellinghaus, David; Siscovick, David S; Ruderfer, Douglas; Gieger, Christian; Grallert, Harald; Rochtchina, Elena; Atkinson, Elizabeth J; Holliday, Elizabeth G; Boerwinkle, Eric; Salvi, Erika; Bottinger, Erwin P; Murgia, Federico; Rivadeneira, Fernando; Ernst, Florian; Kronenberg, Florian; Hu, Frank B; Navis, Gerjan J; Curhan, Gary C; Ehret, George B; Homuth, Georg; Coassin, Stefan; Thun, Gian-Andri; Pistis, Giorgio; Gambaro, Giovanni; Malerba, Giovanni; Montgomery, Grant W; Eiriksdottir, Gudny; Jacobs, Gunnar; Li, Guo; Wichmann, H-Erich; Campbell, Harry; Schmidt, Helena; Wallaschofski, Henri; Völzke, Henry; Brenner, Hermann; Kroemer, Heyo K; Kramer, Holly; Lin, Honghuang; Leach, I Mateo; Ford, Ian; Guessous, Idris; Rudan, Igor; Prokopenko, Inga; Borecki, Ingrid; Heid, Iris M; Kolcic, Ivana; Persico, Ivana; 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(Peer reviewed; Journal article, 2016)Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...