dc.contributor.advisor | Fossmark, Reidar | |
dc.contributor.advisor | Bringeland, Erling A. | |
dc.contributor.author | Beck, Marianne | |
dc.contributor.author | Bringeland, Erling A. | |
dc.contributor.author | Qvigstad, Gunnar | |
dc.contributor.author | Fossmark, Reidar | |
dc.date.accessioned | 2021-10-21T18:21:42Z | |
dc.date.available | 2021-10-21T18:21:42Z | |
dc.date.issued | 2021 | |
dc.identifier | no.ntnu:inspera:71607394:16618829 | |
dc.identifier.uri | https://hdl.handle.net/11250/2824778 | |
dc.description | Full text not available | |
dc.description.abstract | Bakgrunn
Andelen intervallcancer (IC) ved øvre endoskopi (ØE) har tidligere blitt rapportert å være mellom 4.7% og 9.8% i andre vestlige land. Målet med denne populasjonsbaserte studien var å finne andelen av IC i Midt-Norge og identifisere faktorer knyttet til IC.
Metode
Dette var en retrospektiv populasjonsbasert kohortstudie med 730 pasienter diagnostisert med adenokarsinom i ventrikkel i Midt-Norge 2007-2016. Pasientene ble hentet fra det Norske Kreftregisteret og det Norske Pasientregisteret, og hver pasients journal ble gjennomgått manuelt. IC ble definert som adenokarsinom i ventrikkel diagnostisert mellom 6 og 36 måneder etter en tidligere ØE. Faktorer assosiert med IC ble undersøkt. Intervallcancere ble delt inn i definitivt oversett (ØE 6-12 måneder før diagnose) og potensielt oversett (ØE 12-36 måneder før diagnose) og gruppenes egenskaper ble sammenlignet.
Resultat
Av 730 pasienter med ventrikkelcancer var 67 pasienter IC og frekvensen av IC var 9.2%. IC var assosiert med cancer lokalisert i corpus (p = 0.009), Laurens histologisk type diffus (p = 0.028) og tidligere Billroth 2-anastomose (14.9% vs. 4.7%, p = 0.001). IC hadde en tendens til å bli diagnostisert på et tidligere stadium, men dette funnet var ikke signifikant (p = 0.22). Ulcus ble oftere funnet ved ØE hos pasienter med definitivt oversett versus potensielt oversett ventrikkelcancer (40.9% mot 17.8%, p = 0.041).
Konklusjon
IC utgjorde 9.2% av ventrikkecancere i Midt-Norge. IC var assosiert med lokalisering i corpus, Lauren diffuse type og tidligere Billroth-2-anastomose. Intensivert oppfølging og tilstrekkelig biopsitaking av pasienter med ulcus kan gjøre at færre ventrikkelcancere blir oversett. | |
dc.description.abstract | Background
The rate of missed gastric cancer (MGC) at upper endoscopy (UE) have previously been reported to be between 4.7% and 9.8% in other Western countries. The aim of this population-based study was to calculate the rate of MGC in Central Norway and identify factors associated with MGC.
Methods
This was a retrospective population-based cohort study including 730 patients diagnosed with gastric adenocarcinoma in Central Norway 2007-2016. Patients were identified from the Norwegian Cancer Registry and the Norwegian Patient Registry and each patients’ medical record was reviewed manually. MGC was defined as incident gastric adenocarcinoma diagnosed between 6 and 36 months after a previous UE. Factors associated with MGC were examined. MGCs were subdivided into definitely missed (UE 6-12 months prior) and potentially missed (UE 12-36 months prior) and their characteristics were compared.
Results
Out of 730 patients with gastric cancer, 67 patients were MGCs and the rate of MGC was 9.2%. MGC was associated with localization (p=0.009) with MGC more frequently in the corpus, Laurens histological type (p=0.028) with diffuse type more frequent among MGCs and previous Billroth 2-anastomosis (14.9% vs. 4.7%, p = 0.001). MGC tended to be diagnosed at an earlier stage, but not significantly (p=0.22). An ulceration was more frequently found at the UE prior to the diagnosis in patients with definitely missed versus potentially missed gastric cancer (40.9% vs. 17.8%, p=0.041).
Conclusions
MGC accounted for 9.2% of gastric cancers in Central Norway. MGC was associated with localization in the corpus, Lauren distribution diffuse and previous Billroth-2-anastomosis. Intensified follow-up and adequate biopsy sampling of patients with gastric ulcerations could reduce the rate of missed gastric cancer. | |
dc.language | eng | |
dc.publisher | NTNU | |
dc.title | Gastric cancers missed at upper endoscopy in Central Norway 2007 to 2016 - a population-based study | |
dc.type | Master thesis | |