dc.contributor.author | Høgestøl, Ingvild Kristine | |
dc.contributor.author | Aasbrenn, Martin | |
dc.contributor.author | Chahal-Kummen, Monica | |
dc.contributor.author | Brunborg, Cathrine | |
dc.contributor.author | Eribe, Inger | |
dc.contributor.author | Kristinsson, Jon Adalsteinn | |
dc.contributor.author | Farup, Per Grønaas | |
dc.contributor.author | Mala, Tom | |
dc.date.accessioned | 2020-01-31T12:01:42Z | |
dc.date.available | 2020-01-31T12:01:42Z | |
dc.date.created | 2020-01-06T21:05:06Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | BMC Gastroenterology. 2019, 19:204 1-11. | nb_NO |
dc.identifier.issn | 1471-230X | |
dc.identifier.uri | http://hdl.handle.net/11250/2639052 | |
dc.description.abstract | BACKGROUND: Irritable bowel syndrome (IBS) is prevalent in patients with morbid obesity. After Roux-en-Y gastric bypass (RYGB) chronic abdominal pain is common, however the etiology is largely unknown. We aimed to study the change in the prevalence of IBS-like symptoms 2 years after RYGB and possible preoperative predictors of such symptoms. Secondly, to evaluate changes in symptoms of constipation and diarrhea, and Health related quality of life (HRQoL). METHODS: Patients with morbid obesity were included at two obesity centers in South-Eastern Norway. IBS was diagnosed according to the Rome III criteria. Predictors were evaluated in a multivariable logistic regression analysis. RESULTS: Of 307 participants operated with RYGB, 233 (76%) completed the study questionnaires. Preoperatively 27/233 participants (12%) had IBS, 2 years after RYGB 61/233 (26%) had IBS-like symptoms (p < 0.001). Eleven participants with IBS preoperatively (41%) did not report such symptoms after RYGB. New onset IBS-like symptoms was identified in 45/206 (22%) after RYGB. Fibromyalgia, low LDL levels, high vitamin B1 levels and IBS before RYGB were independent preoperative predictors of IBS-like symptoms at the follow-up visit. Symptom scores for constipation preoperatively and 2 year after RYGB were 1.5 (0.9) and 1.8 (1.2), and for diarrhea 1.4 (0.9) and 1.8 (1.1), respectively (p < 0.001). We observed a significant improvement in the physical component score for all participants. However, participants with new onset IBS-like symptoms had a significant worsening of the mental component score. CONCLUSIONS: The prevalence of IBS-like symptoms doubled 2 years after RYGB, and these symptoms were associated with reduced HRQoL. Preoperative IBS and fibromyalgia were strong predictors of postoperative IBS-like symptoms. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BioMed Central | nb_NO |
dc.relation.uri | https://bmcgastroenterol.biomedcentral.com/track/pdf/10.1186/s12876-019-1103-0 | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Irritable bowel syndrome-like symptoms and health related quality of life two years after Roux-en-Y gastric bypass - a prospective cohort study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-11 | nb_NO |
dc.source.volume | 19:204 | nb_NO |
dc.source.journal | BMC Gastroenterology | nb_NO |
dc.identifier.doi | 10.1186/s12876-019-1103-0 | |
dc.identifier.cristin | 1767238 | |
dc.description.localcode | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |