Adverse effects of proton pump inhibitors – evidence and plausibility
Journal article, Peer reviewed
Published version
Åpne
Permanent lenke
http://hdl.handle.net/11250/2627112Utgivelsesdato
2019Metadata
Vis full innførselSamlinger
Originalversjon
10.3390/ijms20205203Sammendrag
Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential side effects are causal. However, important evidence from experimental and mechanistic studies that could support a causal relationship may have been underestimated by epidemiologists and meta-analysists. In the current manuscript we review the combined epidemiological and mechanistic evidence of the adverse effects of PPI use.