dc.contributor.advisor | Hoff, Bård Helge | |
dc.contributor.author | Willumsen, Fredrik Bysting | |
dc.date.accessioned | 2019-09-11T10:35:53Z | |
dc.date.created | 2015-05-15 | |
dc.date.issued | 2015 | |
dc.identifier | ntnudaim:10367 | |
dc.identifier.uri | http://hdl.handle.net/11250/2615613 | |
dc.description.abstract | Reaction conditions were investigated and developed for coupling of acrylates with
different properties. A total of seven acrylic thienopyrimidines were
synthesized, five of which were synthesized directly with the Heck reaction. Testing of in vitro enzymatic inhibition activity indicated that the acrylic moieties
has potential as very selective inhibitors, but due cis-trans isomerization problems,
they are unsuitable for pharmaceutical use. Computer calculations indicate that
the bioavailability properties of the acrylic moiety are improved, compared to the
aryl moiety. Several acrylates were tested as a result of the project and the thesis
postulates some new and stable, potential candidates with similar biological interactions. | en |
dc.language | eng | |
dc.publisher | NTNU | |
dc.subject | Kjemi, Organisk kjemi | en |
dc.title | The Heck reaction for synthesis of novel kinase inhibitors. | en |
dc.type | Master thesis | en |
dc.source.pagenumber | 193 | |
dc.contributor.department | Norges teknisk-naturvitenskapelige universitet, Fakultet for naturvitenskap,Institutt for kjemi | nb_NO |
dc.date.embargoenddate | 10000-01-01 | |