dc.contributor.author | Rekdal, Mikal | |
dc.contributor.author | pai, Aravind | |
dc.contributor.author | BS, Muddukrishna | |
dc.date.accessioned | 2019-09-06T09:02:12Z | |
dc.date.available | 2019-09-06T09:02:12Z | |
dc.date.created | 2018-11-23T11:18:22Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Data in Brief. 2018, 16 135-140. | nb_NO |
dc.identifier.issn | 2352-3409 | |
dc.identifier.uri | http://hdl.handle.net/11250/2612889 | |
dc.description.abstract | Etravirine is a drug used alongside other medication in the treatment of HIV and is a non-nucleoside reverse transcriptase inhibitor. It is a BCS class IV drug, having low solubility and high permeability (Drugbank, https://www.drugbank.ca/drugs/DB06414) [1]. As a result, large doses of the drug are required for treatment. Two pills have to be taken twice a day, making it a “pill burden” (Intelence, http://www.intelence.com/hcp/dosing/administration-options) [2]. Therefore, attempts of co-crystallizing Etravirine are attractive as the solubility of the drug tends to increase in this solid form (Schultheiss and Newman, 2009) [3].
In this study Etravirine co-crystals were synthesized in the molar ratios 1:1, 1:2 and 2:1 with L-tartaric acid as the co-former. Both slow evaporation and physical mixture was performed to mix the components. DSC values of final products are presented as well as FTIR spectra to observe the altered intermolecular interactions. A chemical stability test was performed after seven days using area under curve data from an HPLC instrument. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Experimental data of co-crystals of Etravirine and L-tartaric acid | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 135-140 | nb_NO |
dc.source.volume | 16 | nb_NO |
dc.source.journal | Data in Brief | nb_NO |
dc.identifier.doi | 10.1016/j.dib.2017.11.019 | |
dc.identifier.cristin | 1634197 | |
dc.description.localcode | (C) 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | nb_NO |
cristin.unitcode | 194,66,30,0 | |
cristin.unitname | Institutt for kjemisk prosessteknologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |