Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne; Halvorsen, Bente
Journal article, Peer reviewed
Published version
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http://hdl.handle.net/11250/2603744Utgivelsesdato
2018Metadata
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Sammendrag
Background
The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with non-ST-elevation myocardial infarction (NSTEMI).
Methods
Lp(a) was assessed by immunoassay (n = 117 patients) at 7 consecutive time-points between day 1 and 3 and at 3 and 6 months follow-up.
Results
Tocilizumab did not affect Lp(a) at any time-point during the study and was not associated with cardiovascular risk factors.
Conclusions
Short-time inhibition of IL-6 with tocilizumab in patients with NSTEMI did not influence Lp(a) levels.