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dc.contributor.authorGemes, Katalin
dc.contributor.authorJanszky, Imre
dc.contributor.authorStrand, Linn B
dc.contributor.authorLászló, Krisztina D.
dc.contributor.authorAhnve, Staffan
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorDalen, Håvard
dc.contributor.authorMukamal, Kenneth J
dc.date.accessioned2018-05-16T07:01:49Z
dc.date.available2018-05-16T07:01:49Z
dc.date.created2018-05-15T10:29:33Z
dc.date.issued2018
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/11250/2498251
dc.description.abstractObjectives To investigate the association between alcohol consumption and left ventricular (LV) function in a population with low average alcohol intake. Design, setting and participants A total of 1296 healthy participants, free from cardiovascular diseases, were randomly selected from the third wave of the Norwegian HUNT study (2006–2008) and underwent echocardiography. After validation of the inclusion criteria, 30 participants were excluded due to arrhythmias or myocardial or valvular pathology. Alcohol consumption, sociodemographic and major cardiovascular risk factors were assessed by questionnaires and clinical examination in the HUNT3. General linear models were used to analyse the cross-sectional associations between alcohol intake and LV indices. Primary and secondary outcome measures LV functional and structural indices were measured with tissue Doppler and speckle tracking echocardiography. Results We observed no associations between alcohol consumption and multivariable-adjusted LV functional indices. Excluding abstainers who reported regular alcohol consumption 10 years prior to the baseline did not change the results. Alcohol consumption was positively associated with LV mass indices (p<0.01 for linear trend of the means); there was no such association among participants with non-risky drinking characteristics (p=0.67 for linear trend of the means). Conclusions We found no clear evidence that light–moderate alcohol consumption is associated with measures of LV function, although our results indicate that consumption, especially when marked by binge drinking, is progressively associated with greater LV mass.nb_NO
dc.language.isoengnb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleLight-moderate alcohol consumption and left ventricular function among healthy, middle-aged adults: the HUNT studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.journalBMJ Opennb_NO
dc.identifier.doi10.1136/bmjopen-2017-020777
dc.identifier.cristin1585040
dc.description.localcode© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license.nb_NO
cristin.unitcode194,65,20,0
cristin.unitcode194,65,25,0
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal