dc.contributor.author | Khan, S | |
dc.contributor.author | Mai, Xiao-Mei | |
dc.contributor.author | Chen, Y | |
dc.date.accessioned | 2017-11-15T14:53:02Z | |
dc.date.available | 2017-11-15T14:53:02Z | |
dc.date.created | 2014-03-03T08:45:01Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | American Journal of Clinical Nutrition. 2013, 98 (1), 174-179. | nb_NO |
dc.identifier.issn | 0002-9165 | |
dc.identifier.uri | http://hdl.handle.net/11250/2466514 | |
dc.description.abstract | Background: Vitamin D deficiency is an important health issue, particularly among people residing in northern countries. Low concentrations of 25-hydroxyvitamin D [25(OH)D] have been linked to several health conditions.
Objective: The objective was to determine the association between plasma 25(OH)D and pulmonary function and the effect modifications of sex and body mass index (BMI) in adults.
Design: A cross-sectional study included 3359 adults aged ≥18 y who participated in the Canadian Health Measures Survey, and a 2-stage multiple linear regression analysis was conducted.
Results: Overall, 26% of the adults had a plasma 25(OH)D concentration <50 nmol/L, which is considered deficient (ie, hypovitaminosis D). This deficiency was more prevalent among men than among women (30% compared with 23%). Regression analysis showed that deficient plasma 25(OH)D was associated with lower mean residual forced vital capacity and forced expiratory volume in 1 s in men after adjustment for covariates. When further stratified by BMI, the associations were more marked in overweight and obese men. Vitamin D deficiency associated with pulmonary function was not statistically significant in normal-weight men or in women, regardless of BMI categories. Similar results were obtained when plasma 25(OH)D was examined as a continuous variable in the models.
Conclusions: Hypovitaminosis D may be a risk factor for lung dysfunction, especially for overweight and obese men. Further research is necessary to determine the mechanism of the interrelation between vitamin D, adiposity, and pulmonary function. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | American Society for Nutrition | nb_NO |
dc.title | Plasma 25-hydroxyvitamin D associated with pulmonary function in Canadian adults with excess adiposity | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 174-179 | nb_NO |
dc.source.volume | 98 | nb_NO |
dc.source.journal | American Journal of Clinical Nutrition | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.doi | 10.3945/ajcn.112.054734 | |
dc.identifier.cristin | 1119607 | |
dc.relation.project | Norges forskningsråd: 201895 | nb_NO |
dc.description.localcode | This article will not be available due to copyright restrictions (c) 2013 by American Society for Nutrition | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitname | Institutt for samfunnsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |