dc.contributor.author | Hagen, Knut | |
dc.contributor.author | Pettersen, Elin | |
dc.contributor.author | Stovner, Lars Jacob | |
dc.contributor.author | Skorpen, Frank | |
dc.contributor.author | Zwart, John-Anker | |
dc.date.accessioned | 2015-09-21T12:55:11Z | |
dc.date.accessioned | 2016-06-15T07:11:32Z | |
dc.date.available | 2015-09-21T12:55:11Z | |
dc.date.available | 2016-06-15T07:11:32Z | |
dc.date.issued | 2006-05-04 | |
dc.identifier.citation | BMC Musculoskeletal Disorders 2006, 4:7-40 | nb_NO |
dc.identifier.issn | 1471-2474 | |
dc.identifier.uri | http://hdl.handle.net/11250/2392598 | |
dc.description.abstract | Background: The Catechol-O-methyltransferase (COMT) gene contains a functional
polymorphism, Val158Met, that has been found to influence human pain perception. In one study
fibromyalgia was less likely among those with Val/Val genotype.
Methods: In the 1995–97 Nord-Trøndelag Health Study (HUNT), the association between Val/
Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was
evaluated in a random sample of 3017 individuals.
Results: The distribution of the COMT Val158Met genotypes and alleles were similar between
controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met
genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar
between controls and the chronic MSCs groups.
Conclusion: In this population-based study, no significant association was found between Val/Met
polymorphism at the COMT gene and chronic MSCs. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BioMed Central | nb_NO |
dc.rights | Navngivelse 3.0 Norge | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/no/ | * |
dc.title | No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.date.updated | 2015-09-21T12:55:11Z | |
dc.source.volume | 7 | nb_NO |
dc.source.journal | BMC Musculoskeletal Disorders | nb_NO |
dc.source.issue | 40 | nb_NO |
dc.identifier.doi | 10.1186/1471-2474-7-40 | |
dc.identifier.cristin | 378578 | |
dc.description.localcode | © 2006 Hagen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |