Institutt for klinisk og molekylær medisin: Nye registreringer
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TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy
(Doctoral theses at NTNU;2024:74, Doctoral thesis, 2024)TAK1- and IAP-inhibitors as novel approaches to multiple myeloma therapy Multiple myeloma is a hematological malignancy characterized by accumulation of malignant plasma cells in the bone marrow. This can lead to uncontrolled ... -
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
(Peer reviewed; Journal article, 2023)Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target ... -
Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial
(Peer reviewed; Journal article, 2023)Rationale & Objective In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could ... -
No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway
(Peer reviewed; Journal article, 2024)Objective There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between ... -
Ultrasound and microbubble-enhanced therapy of Gastrointestinal tumors using conventional cytotoxic drugs in preclinical and clinical settings
(Doctoral theses at NTNU;2024:94, Doctoral thesis, 2024)Pancreatic ducal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a very short life expectancy. Together with late diagnosis and aggressive biology, chemoresistance is one important cause of poor survival. ... -
Healthy ageing from birth to age 84 years in the Helsinki Birth Cohort Study, Finland: a longitudinal study
(Peer reviewed; Journal article, 2023)Background The true prevalence of healthy ageing on a population level is unknown. In this study we aimed to examine the upper limit for the prevalence of healthy ageing, by quantifying the probability of surviving and ... -
Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
(Peer reviewed; Journal article, 2024)Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs ... -
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
(Peer reviewed; Journal article, 2023)The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured ... -
Inflammation and Digestive Cancer
(Journal article; Peer reviewed, 2023)Chronic inflammation is linked to carcinogenesis, particularly in the digestive organs, i.e., the stomach, colon, and liver. The mechanism of this effect has, however, only partly been focused on. In this review, we focus ... -
APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway
(Peer reviewed; Journal article, 2023)Abstract: Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations ... -
Methplotlib: Analysis of modified nucleotides from nanopore sequencing
(Journal article; Peer reviewed, 2020)Summary Modified nucleotides play a crucial role in gene expression regulation. Here, we describe methplotlib, a tool developed for the visualization of modified nucleotides detected from Oxford Nanopore Technologies ... -
Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma
(Journal article; Peer reviewed, 2023)Background Despite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers ... -
Gestational diabetes is associated with the risk of offspring's congenital anomalies: a register-based cohort study
(Peer reviewed; Journal article, 2023)Background Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of ... -
Støtte til fallforebygging hos eldre
(Journal article; Peer reviewed, 2023) -
Effectiveness of a group-based Diabetes Prevention Education Program (DiPEP) in a population with pre-diabetes: a cluster randomised controlled trial in Nepal
(Journal article; Peer reviewed, 2023)Background Although several lifestyle intervention studies have been conducted in low/middle-income countries, there were no such studies in Nepal. Therefore, a group-based culturally tailored Diabetes Prevention Education ... -
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
(Journal article; Peer reviewed, 2023)Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature ... -
Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma
(Peer reviewed; Journal article, 2023)Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ... -
Antenatal corticosteroid treatment and infectious diseases in children: a nationwide observational study
(Peer reviewed; Journal article, 2023)Background Antenatal Corticosteroid Treatment (ACT) improves the outcome of preterm infants, but may influence immune system development and risk of immune-related diseases. We investigated whether ACT is associated ... -
Quality learning in undergraduate medical education - Improving teaching and assessment practices
(Doctoral theses at NTNU;2024:88, Doctoral thesis, 2024)Although there have been significant advancements in our understanding of human learning over the last century, many educational practices within the medical field have not integrated educational research findings. ...