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Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG
(Journal article; Peer reviewed, 2017)Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ... -
Uracil DNA Glycosylase UNG2 carrying the germline mutation Arg88Cys: Potential implications for adaptive immunity and cancer
(Master thesis, 2011)Uracil is normally found in RNA where it replaces the DNA base thymine. However, it can occur in DNA if misincorporated in place of thymine, or as a result of deamination of cytosine. Uracil is also a normal intermediate ... -
Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A
(Journal article; Peer reviewed, 2011)Uracil is removed from DNA by the conserved enzyme Uracil DNA N-glycosylase (UNG). Previously, we observed that inhibiting UNG in Xenopus egg extracts blocked assembly of CENP-A, a histone H3 variant. CENP-A is an essential ... -
Uracil in DNA - necessary intermediate for antibody maturation and mutagenic lesion
(Doctoral thesis at NTNU;2015:153, Doctoral thesis, 2015)Uracil in DNA - et viktig mellomprodukt for adaptiv immunitet og mutagen skade Uracil er en av fire nukleobaser i RNA, men små mengder kan også befinne seg i DNA. Det er to kilder til genomisk uracil: misinkorporering ... -
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
(Journal article; Peer reviewed, 2019)UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in ... -
Uracil-DNA glycosylase, activation-induced deaminase and regulation of adaptive immune responses
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:318, Doctoral thesis, 2012)Uracil-DNA glykosylase, activation-induced deaminase og regulering av ervervet immunitet Det eksterne miljøet er rikt på potensielle farer for alle multicellulære organismer. Det mammalske immunforsvaret er en barriere ... -
Ureteric injuries during hysterectomy—A Norwegian retrospective study of occurrence and claims for compensation over an 11-year period
(Peer reviewed; Journal article, 2021)Introduction: Ureteric injury is a rare but serious, iatrogenic complication of hysterectomy. The risk depends on indication for surgery, predisposing risk factors, and peroperative conditions. Our aims were to evaluate ... -
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
(Journal article; Peer reviewed, 2013)Objective: To investigate urine albumin leakage as a marker of endothelial dysfunction in migraine patients. Design: A population-based health study. Participants: 303 patients with migraine, 1009 patients with ... -
Urinary and colorectal-anal distress in women - prevalence, risk factors and effect of pelvic floor muscle exercise in women with pelvic organ prolapse
(Doctoral theses at NTNU;2021:199, Doctoral thesis, 2021) -
Urinary incontinence and drug use: Data from the Norwegian Prescription Database and the HUNT3 study
(Doctoral theses at NTNU;2018:125, Doctoral thesis, 2018)Introduction Urinary incontinence is a common health problem in the female population. The most common drug group used for the treatment of urgency urinary incontinence is anticholinergic drugs, including oxybutynin, ... -
Urinary Incontinence and Urinary Tract Infections in the Elderly: Risk Factors and Consequences
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:342, Doctoral thesis, 2012) -
Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria
(Journal article; Peer reviewed, 2015)Background: The contrast between a high prevalence of chronic kidney disease (CKD) and the low incidence of end-stage renal disease highlights the need for new biomarkers of progression beyond albuminuria testing. ... -
Urinveisinfeksjoner ved St. Olavs hospital HF
(Master thesis, 2020)Urinveisinfeksjoner (UVI) er blant de vanligste bakterielle infeksjonene og er årsak til en betydelig andel av antibiotikaforbruket i Norge. Over halvparten av alle kvinner vil gjennomgå én eller flere tilfeller av UVI i ... -
Usability testing of EirV3-a computer-based tool for patient-reported outcome measures in cancer
(Journal article, 2018)Purpose Eir version 3 (V3) is an electronic tool for administration of patient-reported outcome measures (Eir-Patient) that immediately presents patient scores on the physician’s computer (Eir-Doctor). Perceived usability ... -
Use and validity of child neurodevelopment outcome measures in studies on prenatal exposure to psychotropic and analgesic medications – A systematic review
(Journal article; Peer reviewed, 2019)In recent years there has been increased attention to child neurodevelopment in studies on medication safety in pregnancy. Neurodevelopment is a multifactorial outcome that can be assessed by various assessors, using ... -
Use of CRISPR/Cas9-Mediated Genome Editing in Human Induced Pluripotent Stem Cells to Study Oxidative Base Lesion Repair in Cerebral Organoids
(Master thesis, 2020)The role of DNA glycosylase OGG1 beyond the base excision repair (BER) pathway involves regulation of brain development and function. However, the molecular mechanisms remain to be unravelled. Here, we describe a reliable ... -
Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment
(Peer reviewed; Journal article, 2022)Objectives: Elevated low-density lipoprotein cholesterol (LDL-C) increases the risk of recurrent cardiovascular disease (CVD) events. We examined use of lipid-lowering therapy (LLT) following ischaemic stroke, and estimated ... -
Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment
(Journal article; Peer reviewed, 2022) -
Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome
(Journal article; Peer reviewed, 2017)Background Many families with a high burden of colorectal cancer fulfil the clinical criteria for Lynch Syndrome. However, in about half of these families, no germline mutation in the mismatch repair genes known to be ... -
Use of new sequencing technology to improve clinical diagnostics of hereditary colorectal cancer
(Doctoral theses at NTNU;2018:94, Doctoral thesis, 2018)Backgroud: Identification of a germline pathogenic variant that causes increased risk and aggregation of CRC in a family is important for the clinical management of the family members. Next generation sequencing technology ...