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    • Synaptic input as a directional cue for migrating interneuron precursors 

      Wefers, Annika K; Haberlandt, Christian; Tekin, Nuriye Basdag; Fedorov, D.; Timmermann, A.; Van der Want, Johannes; Chaudhry, Farrukh Abbas; Steinhäuser, Christian; Schilling, K; Jabs, Ronald (Journal article; Peer reviewed, 2017)
      During CNS development, interneuron precursors have to migrate extensively before they integrate in specific microcircuits. Known regulators of neuronal motility include classical neurotransmitters, yet the mechanisms that ...

    • Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice 

      Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne; Bjørås, Magnar (Journal article; Peer reviewed, 2015)
      Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these ...

    • Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections 

      Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji; Yang, Jaewon; Ravlo, Erlend; Wang, Wei; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Tenson, Tanel; Windisch, Marc P.; Poranen, Minna M.; Nieminen, Anni I.; Nordbø, Svein Arne; Fenstad, Mona H.; Grødeland, Gunnveig; Aukrust, Pål; Trøseid, Marius; Kantele, Anu; Lastauskienė, Eglė; Vitkauskienė, Astra; Legrand, Nicolas; Merits, Andres; Bjørås, Magnar; Kainov, Denis (Journal article; Peer reviewed, 2021)
      Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in ...

    • Synergistic Role between p53 and JWA: Prognostic and Predictive Biomarkers in Gastric Cancer 

      Liu, Xin; Wang, Shouyu; Xia, Xiaowei; Chen, Yansu; Zhou, Yan; Wu, Xuming; Zhang, Jianbing; He, Song; Tan, YongFei; Qiang, FuLin; Røe, Oluf Dimitri; Li, Gang; Zhou, Jianwei (Journal article; Peer reviewed, 2012)
      Expression of p53 appears to be correlated to prognosis in patients with malignancy, but its role in gastric carcinoma has remained controversial. Recently we reported that JWA, an ADP-ribosylation-like factor 6 interacting ...

    • Syntese av fenylpropanoider ved bruk av trekomponentsyntese med Bestmann-ylid 

      Ryjoan Karwan Ahmed Ahmed (Master thesis, 2022)
      Fenylpropanoider er plante sekundærmetabolitter og har i de siste årene fått oppmerksomhet da de har vist forskjellige biologiske effekter. Målet for dette master prosjektet var å danne et kjemisk bibliotek av fenylpropanoid ...

    • Syntetiske studier av chrysogeamide A og B 

      Ervik, Karina (Master thesis, 2020)
      En av de største utfordringene i dagens samfunn er utviklingen av antibiotikaresistens hos bakterier. For å forhindre at bakterielle infeksjoner blir like dødelig som før oppdagelsen av antibiotika er det helt avgjørende ...

    • Synthesis of Scopularide A and B 

      Halvorsen Brenna, Eivind (Master thesis, 2020)
      Scopularid A og B er en del av en familie av sykloheksadepsipeptider som har vist å ha betydelig effekt mot tumorvekst hos visse typer kreftceller. For å studere denne effekten i større detalj, så har det blitt utprøvd en ...

    • The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model 

      Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Peer reviewed; Journal article, 2019)
      The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host ...

    • The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model 

      Granslo, Hildegunn Norbakken; Aarag, Elizabeth; Esaiassen, Eirin; Christophersen, Lars; Jensen, Peter Østrup; Mollnes, Tom Eirik; Moser, Claus; Flægstad, Trond; Klingenberg, Claus; Cavanagh, Jorunn Pauline (Peer reviewed; Journal article, 2019)
      The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host ...

    • Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53 

      Castañeda-Zegarra, Sergio; Xing, Mengtan; Gago-Fuentes, Raquel; Sæterstad, Siri; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)
      Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core Ku70 and Ku80 subunits bind DSBs as a heterodimer ...

    • Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70 

      Xing, Mengtan; Bjørås, Magnar; Daniel, Jeremy A.; Alt, Frederick W.; Oksenych, Valentyn (Journal article; Peer reviewed, 2017)
      DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds ...

    • Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release 

      de Boer, Eline; Sokolova, Marina; Quach, Huy Quang; Mc Adam, Karin Ekholt; Götz, Maximilian P.; Chaban, Viktoriia; Vaage, Ingvar Jarle; Fageräng, Beatrice Linnea Christina; Woodruff, Trent M.; Garred, Peter; Nilsson, Per; Mollnes, Tom Eirik; Pischke, Soeren (Peer reviewed; Journal article, 2022)
      Bacterial and mitochondrial DNA, sharing an evolutionary origin, act as danger-associated molecular patterns in infectious and sterile inflammation. They both contain immunomodulatory CpG motifs. Interactions between CpG ...

    • Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents 

      Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2021)
      Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ...

    • A systematic review examining nutrition support interventions in patients with incurable cancer 

      Blackwood, Honor A.; Hall, Charlie C.; Balstad, Trude Rakel; Solheim, Tora Skeidsvoll; Fallon, Marie; Haraldsdottir, Erna; Laird, Barry J (Peer reviewed; Journal article, 2019)
      Purpose Recent guidelines by the European Society for Clinical Nutrition and Metabolism (ESPEN) have advocated increased attention to nutritional support in all patients with cancer; however, little is known about the ...

    • Systematic review: predictive value of organoids in colorectal cancer 

      Sakshaug, Baard Cristoffer; Folkesson, Emma Evelina; Haukaas, Tonje Husby; Visnes, Torkild; Flobak, Åsmund (Peer reviewed; Journal article, 2023)
      While chemotherapy alone or in combination with radiotherapy and surgery are important modalities in the treatment of colorectal cancer, their widespread use is not paired with an abundance of diagnostic tools to match ...

    • Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients 

      Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne; Holten, Aleksander Rygh; Tonby, Kristian; Barratt-Due, Andreas; Sokolova, Marina; Schjalm, Camilla; Chaban, Viktoriia; Kolderup, Anette; Tran, Trung; Tollefsrud Gjølberg, Torleif; Skeie, Linda Gail; Hesstvedt, Liv; Ormåsen, Vidar; Fevang, Børre; Austad, Cathrine; Muller, Karl Erik; Fladeby, Cathrine; Holberg-Petersen, Mona; Halvorsen, Bente; Müller, Fredrik; Aukrust, Pål; Dudman, Susanne Gjeruldsen; Ueland, Thor; Andersen, Jan Terje; Lund-Johansen, Fridtjof; Heggelund, Lars; Dyrhol-Riise, Anne Ma; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2020)
      Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ...

    • Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study 

      Rath, Eivind; Palma Medina, Laura M.; Jahagirdar, Sanjeevan; Mosevoll, Knut Anders; Damås, Jan Kristian; Madsen, Martin B.; Svensson, Mattias; Hyldegaard, Ole; Martins dos Santos, Vitor A.P.; Saccenti, Edoardo; Norrby-Teglund, Anna; Skrede, Steinar; Bruun, Trond (Peer reviewed; Journal article, 2023)
      Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ...

    • Systemic inflammation persists the first year after mild traumatic brain injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study 

      Chaban, Viktoriia; Clarke, Gerard; Skandsen, Toril; Islam, Rakibul; Einarsen, Cathrine Elisabeth; Vik, Anne; Damås, Jan Kristian; Mollnes, Tom Eirik; Håberg, Asta; Pischke, Soeren (Peer reviewed; Journal article, 2020)
      Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate immune activation are unknown. We determined ...

    • Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation 

      Holm, Mari; Morken, Tora Sund; Fichorova, Raina Nakove; VanderVeen, Deborah; Allred, Elizabeth; Dammann, Olaf; Leviton, Alan (Peer reviewed; Journal article, 2017)
      PURPOSE. To assess the association between systemic levels of inflammation-associated proteins and severe retinopathy of prematurity (ROP) in extremely preterm infants. METHODS. We collected whole blood on filter paper on ...

    • Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention 

      Rø, Anne Dorthea Bjerkenes; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae (Peer reviewed; Journal article, 2023)
      Background Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondheim ...