Browsing Institutt for klinisk og molekylær medisin by Title
Now showing items 270-289 of 3430
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Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
(Peer reviewed; Journal article, 2020)Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ... -
Atezolizumab and stereotactic body radiotherapy in patients with advanced non-small cell lung cancer: safety, clinical activity and ctDNA responses—the ComIT-1 trial
(Peer reviewed; Journal article, 2022)The introduction of immune checkpoint inhibitors has transformed the treatment landscape of metastatic non-small cell lung cancer. However, challenges remain to increase the fraction of patients achieving durable clinical ... -
Atherosclerotic and obesity-associated inflammation : focus on cholesterol crystals, complement and coagulation
(Master thesis, 2015)Atherosclerosis is a chronic inflammatory disease of the arterial wall, and a leading cause of death worldwide. An emerging role for the complement system in the pathogenesis of atherosclerosis is demonstrated by the ... -
ATM instigate melphalan mediated damage response in multiple myeloma: the tip of the iceberg
(Master thesis, 2021)INNLEDNING: Myelomatose (MM) er en uhelbredelig hematologisk krefttype preget av hyperproliferasjon av plasmaceller. Sykdommens robusthet skyldes utvikling av resistens og tilbakefall av sykdommen. Forekomst av minimal ... -
Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity
(Peer reviewed; Journal article, 2013-10-16)Background: Although high aerobic capacity is associated with effective cardiac function, the effect of aerobic capacity on atrial function, especially in terms of cellular mechanisms, is not known. We aimed to investigate ... -
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
(Peer reviewed; Journal article, 2022)Cell proliferation requires the orchestrated actions of a myriad of proteins regulating DNA replication, DNA repair and damage tolerance, and cell cycle. Proliferating cell nuclear antigen (PCNA) is a master regulator which ... -
Atypical brain structure mediates reduced IQ in young adults born preterm with very low birth weight
(Peer reviewed; Journal article, 2022)Preterm birth with very low birth weight (VLBW) confers heightened risk for perinatal brain injury and long-term cognitive deficits, including a reduction in IQ of up to one standard deviation. Persisting gray and white ... -
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia
(Journal article; Peer reviewed, 2019)Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the ... -
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets
(Peer reviewed; Journal article, 2021)COVID-19 outbreak brings intense pressure on healthcare systems, with an urgent demand for effective diagnostic, prognostic and therapeutic procedures. Here, we employed Automated Machine Learning (AutoML) to analyze three ... -
Automated Quantification of Human Osteoclasts Using Object Detection
(Peer reviewed; Journal article, 2022)A balanced skeletal remodeling process is paramount to staying healthy. The remodeling process can be studied by analyzing osteoclasts differentiated in vitro from mononuclear cells isolated from peripheral blood or from ... -
Automatic Detection and Measurement of Fetal Biparietal Diameter and Femur Length — Feasibility on a Portable Ultrasound Device
(Journal article, 2017)An automatic method able to recognize a presented section through the biparietal plane of the fetal head and a section through the fetal femur in ultrasound images is developed. Once the correct anatomical section for ... -
Autophagy as a Survival Mechanism or a Cause of Disease
(Doctoral thesis at NTNU;2016:52, Doctoral thesis, 2016)Proper turnover of cellular components is crucial for all cells. If damaged or excessive content in the cell is not removed at a sufficient pace, normal cell functions may be compromised. The same may occur if the ... -
Autopsy findings of central nervous system anomalies in intact fetuses following termination of pregnancy after prenatal ultrasound diagnosis
(Journal article; Peer reviewed, 2019)Objectives Central nervous system (CNS) anomalies are the second most frequent category of congenital anomalies after congenital heart defects (CHDs). In this study, the aim was to investigate the distribution of different ... -
Avoiding ambient air in test tubes during incubations of human whole-blood minimizes complement background activation
(Peer reviewed; Journal article, 2020)Background In vitro, the complement system can be studied in test tubes incubated with anticoagulated human whole-blood. Background activation of complement may mask inflammatory signals. Air bubbles are known to activate ... -
Avvikshåndtering - noe å lære av? En kvalitativ studie av enhets- og avdelingslederes tanker og erfaringer
(Master thesis, 2021)Bakgrunn Bakgrunnen for denne masteroppgaven er å undersøke hvilke erfaringer ledere har med å håndtere legemiddelhåndteringsavvik i primærhelsetjenesten. Dagens legemiddelbrukere i primærhelsetjenesten lever lengre med ... -
Awareness of cervical cancer and prevalence of human papillomavirus and other sexually transmitted infections among women in rural Nepal.: Implications for future cervical cancer prevention in Nepal
(Doctoral theses at NTNU;2017:87, Doctoral thesis, 2017)Cervical cancer is a leading cause of cancer deaths among women in Nepal. Limited information is available on public awareness on cervical cancer, the prevalence of its causative agents and associated risk factors. No ... -
Awareness of hypoglycemia in type 1 diabetes - On the assessment, prevalence, and clinical associations of impaired awareness of hypoglycemia in children and adults
(Doctoral theses at NTNU;2023:408, Doctoral thesis, 2023)Over one hundred years after the first doses of insulin were given as treatment for type 1 diabetes (TlD), hypoglycemia is still the main factor limiting optimal blood glucose control. Episodes of hypoglycemia are by itself ... -
Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe.
(Journal article; Peer reviewed, 2019)Objective To date, little is known about differences in the knowledge, diagnosis making and treatment strategies of health care providers regarding polycystic ovary syndrome (PCOS) across different disciplines in countries ...