Blar i Institutt for klinisk og molekylær medisin på tittel
Viser treff 1295-1314 av 3585
-
GABAA receptor subunit α3 in network dynamics in the medial entorhinal cortex
(Journal article; Peer reviewed, 2019)Layer II of the medial entorhinal cortex (MEC LII) contains the largest number of spatially modulated grid cells and is one of the first regions in the brain to express Alzheimer’s disease (AD)-related pathology. The most ... -
Gammadelta T cells in Crohn's disease: a new player in the disease pathogenesis?
(Journal article; Peer reviewed, 2017)Crohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. An altered immune response to commensal intestinal bacteria takes place in genetically predisposed individuals, resulting ... -
GAPGOM—an R package for gene annotation prediction using GO metrics
(Peer reviewed; Journal article, 2021)Objective Properties of gene products can be described or annotated with Gene Ontology (GO) terms. But for many genes we have limited information about their products, for example with respect to function. This is ... -
Gastric Adenocarcinoma in Central Norway: Incidence, treatment, and long term survival rates, with emphasis on outcomes after introducing perioperative chemotherapy
(Doctoral thesis at NTNU;2016:261, Doctoral thesis, 2016)I løpet av de siste 20 årene er flere endringer gjort i utredning og behandling av pasienter fra Midt Norge med kreft i magesekken. Kartlegging av svulstomfang med snitt røntgen (CT) er standardisert, og selvekspanderende ... -
Gastric cancer in Japanese cotton rats
(Doktoravhandlinger ved NTNU, 1503-8181; 2004:125, Doctoral thesis, 2004)The role of gastrin and the enterochromaffin-like (ECL) cell in human gastric carcinogenesis is not fully understood. There are numerous animal models that can be useful when studying this process. One such model is the ... -
Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—a Population-Based Study
(Peer reviewed; Journal article, 2021)Simple summary: Stomach cancer may be missed during upper endoscopy. We have examined how often this occurs and identified factors associated with missed cancers. Among 730 patients with gastric cancer, 67 (9.2%) were ... -
Gastric Carcinomas Localized to the Cardia
(Journal article; Peer reviewed, 2012)Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
(Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Gastric neuroendocrine cells - role in gastric neoplasia in man and rodents
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:183, Doctoral thesis, 2010)In paper I we showed that neuroendocrine markers could be found in signet ring cancer cells, a cell type thought to originate from exocrine committed cells and thus these tumours have previously been classified as ... -
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells
(Journal article; Peer reviewed, 2017)Background: The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a ... -
Gastrin and gastric cancer
(Journal article; Peer reviewed, 2017)Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced ... -
Gastrin induced autophagy in gastric adenocarcinoma cells
(Master thesis, 2014)The Gastroenterology and Cell biology research group at NTNU studies the role of gastrin in gastric cancer. Gastrin is shown to be involved in proliferation, anti-apoptosis, migration, invasion and angiogenesis. The role ... -
Gastrin regulated activation of proteins in the elF2α-p-ATF4 network
(Master thesis, 2013)This master's thesis is a part of a research project of The Gastroenterology Cell Biology Group investigating molecular responses to gastrin induced gene expression, with focus on how duration and intensity of gastrin ... -
Gastrin-mediated regulation of gene expression; a systems biology approach
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:336, Doctoral thesis, 2012)Gastrin-regulert genuttrykk; en systembiologisk tilnærming I tillegg til å være det viktigste hormonet som kontrollerer utskillelsen av magesyre (saltsyre, HCl), er gastrin også involvert i vekstregulering av mageslimhinnen. ... -
Gastritis, Gastric Polyps and Gastric Cancer
(Peer reviewed; Journal article, 2021)Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction ... -
Gastrointestinal hormones and appetite ratings after weight loss induced by diet or bariatric surgery
(Peer reviewed; Journal article, 2023)Objective The aim of this study was to compare changes in gastrointestinal hormones and appetite ratings after a similar weight loss induced by a very low-energy diet alone or in combination with sleeve gastrectomy (SG) ... -
Gefitinib or Erlotinib as Maintenance Therapy in Patients with Advanced Stage Non-Small Cell Lung Cancer: A Systematic Review
(Journal article; Peer reviewed, 2013)Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), gefitinib and erlotinib have been tested as maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC). The ... -
Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks
(Journal article; Peer reviewed, 2017)Background Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems—the PAXgene and Tempus tubes—differently influence RNA expression signatures. The aim ... -
Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort
(Journal article; Peer reviewed, 2021)Active smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes ... -
Gene expression profile changes after short-activating RNA-mediated induction of endogenous pluripotency factors in human mesenchymal stem cells
(Journal article; Peer reviewed, 2012)It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened ...