dc.contributor.author | Krogvold, Lars | |
dc.contributor.author | Henrichsen, Thore Andre | |
dc.contributor.author | Bjerre, Anna Kristina | |
dc.contributor.author | Brackman, Damien | |
dc.contributor.author | Døllner, Henrik | |
dc.contributor.author | Gudmundsdottir, Helga | |
dc.contributor.author | Næss, Pål Aksel | |
dc.contributor.author | Syversen, Gaute | |
dc.contributor.author | Bangstad, Hans J | |
dc.date.accessioned | 2015-09-25T12:04:57Z | |
dc.date.accessioned | 2015-10-01T12:23:16Z | |
dc.date.available | 2015-09-25T12:04:57Z | |
dc.date.available | 2015-10-01T12:23:16Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2011, 19 | nb_NO |
dc.identifier.issn | 1757-7241 | |
dc.identifier.uri | http://hdl.handle.net/11250/1607141 | |
dc.description.abstract | Background: Report a nationwide epidemic of Shiga toxin-producing E. coli (STEC) O103:H25 causing hemolytic
uremic syndrome (D+HUS) in children.
Methods: Description of clinical presentation, complications and outcome in a nationwide outbreak.
Results: Ten children (median age 4.3 years) developed HUS during the outbreak. One of these was presumed to
be a part of the outbreak without microbiological proof. Eight of the patients were oligoanuric and in need of
dialysis. Median need for dialysis was 15 days; one girl did not regain renal function and received a kidney
transplant. Four patients had seizures and/or reduced consciousness. Cerebral oedema and herniation caused the
death of a 4-year-old boy. Two patients developed necrosis of colon with perforation and one of them developed
non-autoimmune diabetes.
Conclusion: This outbreak of STEC was characterized by a high incidence of HUS among the infected children,
and many developed severe renal disease and extrarenal complications. A likely explanation is that the O103:H25
(eae and stx2-positive) strain was highly pathogen, and we suggest that this serotype should be looked for in
patients with HUS caused by STEC, especially in severe forms or outbreaks. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BioMed Central | nb_NO |
dc.title | Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome (HUS) in children | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | en_GB |
dc.date.updated | 2015-09-25T12:04:57Z | |
dc.source.volume | 19 | nb_NO |
dc.source.journal | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | nb_NO |
dc.identifier.doi | 10.1186/1757-7241-19-44 | |
dc.identifier.cristin | 847532 | |
dc.description.localcode | © 2011 Krogvold et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |