Blar i NTNU Open på forfatter "Zotchev, Sergey B"
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Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: Insights from the promoter fusion studies
Sekurova, Olga N.; Zhang, Jianhai; Kristiansen, Kåre Andre; Zotchev, Sergey B (Peer reviewed; Journal article, 2016)Background Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES), respectively. Biosynthesis of Cml and Jad was shown ... -
An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts
Mevaere, Jimmy; Goulard, Christophe; Schneider, Olha; Sekurova, Olga N.; Ma, Haiyan; Zirah, Severine; Afonso, Carlos; Rebuffat, Sylvie; Zotchev, Sergey B; Li, Yanyan (Journal article; Peer reviewed, 2018)Lasso peptides are ribosomally synthesized and post-translationally modified peptides produced by bacteria. They are characterized by an unusual lariat-knot structure. Targeted genome scanning revealed a wide diversity of ... -
Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic
Schneider, Olha; Simic, Nebojsa; Aachmann, Finn Lillelund; Rückert, Christian; Kristiansen, Kåre Andre; Kalinowski, Jörn; Jiang, Yi; Wang, Lisong; Jiang, Cheng-Lin; Lale, Rahmi; Zotchev, Sergey B (Journal article; Peer reviewed, 2018)Streptomyces bacteria are recognized as an important source for antibiotics with broad applications in human medicine and animal health. Here, we report the isolation of a new lichen-associating Streptomyces sp. YIM 130001 ... -
Genomics-based insights into the biosynthesis and unusually high accumulation of free fatty acids by Streptomyces sp. NP10
Schneider, Olha; Ilic-Tomic, Tatjana; Rückert, Christian; Kalinowski, Jörn; Gencic, Marija S; Zivkovic, Milena Z; Stankovic, Nada; Radulovic, Niko S; Vasiljevic, Branka; Nikodinovic-Runic, Jasmina; Zotchev, Sergey B (Journal article; Peer reviewed, 2018)Streptomyces sp. NP10 was previously shown to synthesize large amounts of free fatty acids (FFAs). In this work, we report the first insights into the biosynthesis of these fatty acids (FAs) gained after genome sequencing ...