Blar i NTNU Open på forfatter "Rognstad, Line"
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Investigation of 4,6-Disubstituted Pyrrolo[2,3-d]pyrimidines as Potential Colony-Stimulating Factor 1 Receptor Inhibitors; Synthesis of Carboxylic Acid Derivatives on the Aromatic Moiety at Position C-6.
Rognstad, Line (Master thesis, 2019)I medisinsk kjemi har små molekyler blitt et viktig forskningsområde innen legemidler. Fusjonerte heterosykler har blitt rapportert til å utfolde en rekke biologiske aktiviteter, og pyrrolopyrimidiner er en av hovedklassene ... -
Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form
Aarhus, Thomas Ihle; Bjørnstad, Frithjof Andreas; Wolowczyk, Camilla Izabel; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjørkøy, Geir; Pridans, Clare; Eickhoff, Jan; Klebl, Bert; Hoff, Bård Helge; Sundby, Eirik (Peer reviewed; Journal article, 2023)Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible ...