Browsing NTNU Open by Author "Oudhoff, Menno"
Now showing items 1-11 of 11
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BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Lindholm, Håvard Takle; Parmar, Naveen; Drurey, Claire; Poveda, Marta Campillo; Vornewald, Pia; Ostrop, Jenny; Sanchez, Alberto Diez; Maizels M, Rick; Oudhoff, Menno (Peer reviewed; Journal article, 2022)Intestinal parasite infections or allergic reactions promote IL-13–induced differentiation of tuft cells as one manifestation of type 2 immunity in the gut. Using organoid cultures of intestinal epithelial cells, Lindholm ... -
Defining changes in the intestinal epithelium in early life and in response to infections
Lindholm, Håvard Takle (Doctoral theses at NTNU;2021:231, Doctoral thesis, 2021) -
Epigenetic control of the intestinal epithelium A role for lysine-specific demethylase 1A during homeostasis and disease
Zwiggelaar, R.T.M. (Doctoral theses at NTNU;2021:151, Doctoral thesis, 2021) -
Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection
Oudhoff, Menno; Antignano, Frann; Chenery, Alistair L; Burrows, Kyle; Redpath, Stephen A; Braam, Mitchell J; Perona-Wright, Georgia; Zaph, Colby (Journal article; Peer reviewed, 2016)The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. Lysine methyltransferases ... -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Ostrop, Jenny; Matono, Mami; Parmar, Naveen; Kvaløy, Emilie; Spanjers, Roos; Nazmi, Kamran; Rye, Morten Beck; Drabløs, Finn; Arrowsmith, Cheryl H; Dahl, John Arne; Jensen, Kim B.; Sato, Toshiro; Oudhoff, Menno (Journal article; Peer reviewed, 2020)Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ... -
Matrix Metalloproteinase (MMP)-17 Regulates Intestinal Regeneration after Irradiation
Hoel, Sigrid (Master thesis, 2019)The intestinal epithelium is a multitasking tissue and has a large flexibility to adapt to different types of insults. This is mostly due to the proliferative intestinal stem cells (ISCs) at the bottom of the intestinal ... -
Orchestrating the intestinal epithelial niche: Intestinal smooth muscle tissue and cytokines in epithelial regulation
Vornewald, Pia M. (Doctoral theses at NTNU;2023:295, Doctoral thesis, 2023)Gut disorders, like inflammatory bowel disease, are becoming increasingly common. To develop better treatments, we need to understand how the gut works and what happens at the cellular level when these disorders occur. ... -
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling
Oudhoff, Menno; Braam, Mitchell JS; Freeman, Spencer A; Wong, Denise; Rattray, David G; Wang, Jia; Antignano, Frann; Snyder, Kimberly; Refaeli, Ido; Hughes, Michael R; McNagny, Kelly M; Gold, Michael R; Arrowsmith, Cheryl H; Sato, Toshiro; Rossi, Fabio MV; Tatlock, John H; Owen, Dafydd R; Brown, Peter J; Zaph, Colby (Journal article; Peer reviewed, 2016)Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are associated with the majority of intestinal ... -
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
Alonso, Mara Martin; Iqbal, Sharif; Vornewald, Pia; Lindholm, Håvard Takle; Damen, Mirjam J.; Martínez, Fernando; Hoel, Sigrid; Sanchez, Alberto Diez; Altelaar, Maarten; Katajisto, Pekka; Arroyo, Alicia G.; Oudhoff, Menno (Peer reviewed; Journal article, 2021)Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells ... -
The role of lysine-specific demethylase 1A (LSD1) in Wnt driven cancer
Brekke, Rita (Master thesis, 2021)Lysine specific demethylase 1A (LSD1) is an epigenetic modifier which interacts with various substrates and has diverse functions. Epigenetic dysregulation is emerging as a hallmark of cancer and thus, epigenetic inhibitors ... -
Unraveling the role of LSD1 in murine intestinal epithelial development
Kvaløy, Emilie (Bachelor thesis, 2019)Background: The intestinal epithelium is a vital organ that absorbs nutrients and water from luminal contents and provide protection against pathogens and chemicals through the stimulation of the immune system and secretion ...