Blar i NTNU Open på forfatter "Rootwelt, Helge"
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APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery
Farup, Per Grønaas; Jansen, Aina; Hestad, Knut; Aaseth, Jan; Rootwelt, Helge (Peer reviewed; Journal article, 2022)Background: Obesity is an interplay between genes and the environment, including lifestyle. The genetics of obesity is insufficiently understood. Apolipoprotein E (APOE) genetic polymorphism has been associated with a wide ... -
APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway
Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2023)Abstract: Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations ... -
APOE – a genetic marker of comorbidity in subjects with morbid obesity
Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2020)Background In population-based studies, the genetic variability of the APOE E alleles have been associated with health outcomes. Health problems are common in subjects with obesity. This study explored associations ... -
Changes in circulating sirtuin 1 after bariatric surgery
Opstad, Trine Baur; Farup, Per Grønaas; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022)Background and aims Obesity is associated with chronic inflammation and oxidative stress. Weight loss after bariatric surgery improves the inflammatory state and risk of cardiovascular disease. Improvement in metabolic ... -
Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut; Farup, Per Grønaas (Peer reviewed; Journal article, 2022)The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the ... -
Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency
Böhm, Hans-Otto; Yazdani, Mazyar; Mørk Sandås, Elise; Østeby Vassli, Anja; Kristensen, Erle; Rootwelt, Helge; Skogvold, Hanne Bendiksen; Brodtkorb, Eylert; Elgstøen, Katja B. Prestø (Peer reviewed; Journal article, 2022)Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive developmental and epileptic encephalopathy caused by pathogenic variants in the ALDH7A1 gene (PDE-ALDH7A1), which mainly has its onset in neonates and ...