Blar i NTNU Open på forfatter "Grill, Valdemar Erik Robert"
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Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study
Bjørnland, Thea; Langaas, Mette; Mostad, Ingrid Løvold; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)Background Our aim was to assess the influence of age, gender and lifestyle factors on the effect of the obesity-promoting alleles of FTO and MCR4. Methods The HUNT study comprises health information on the ... -
Effekter av ketoner og hyperglykemi på mitokondriell funksjon i insulinproduserende β-celler under diabetes-lignende forhold in vitro
Bjørkvik, Astrid (Master thesis, 2021)Bakgrunn: Kronisk hyperglykemi, også kalt "glukotoksisitet", aktiverer ulike signalveier som har skadelige effekter på β-cellenes funksjon og overlevelse. Dette bidrar videre til utvikling av diabetes og både mikro- og ... -
Exploring Dietary Intake in Adults with Severe Obesity and Associations with the FTO rs9939609 Genotypes
De Soysa, Ann Kristin Hjelle; Alho Letra Martins, Catia Patricia; Langaas, Mette; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Peer reviewed; Journal article, 2023)Background Few have studied the associations between rs9939609 genotypes in the obesity candidate locus FTO and energy and nutrient intakes and meal frequencies in adults with severe obesity. We are unaware of studies ... -
The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity
De Soysa, Ann Kristin Hjelle; Langaas, Mette; Jakic, Anida; Shojaee-Moradie, Fariba; Umpleby, A. Margot; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Peer reviewed; Journal article, 2021)The objective of the study was to assess associations of the rs9939609 FTO allele to glucose tolerance, hepatic and total insulin sensitivity (IS) in individuals with obesity. From a low-dose hyperinsulinemic euglycemic ... -
Fructosamine is a useful indicator of hyperglycaemia and glucose control in clinical and epidemiological studies - Cross-sectional and longitudinal experience from the AMORIS cohort
Malmstrøm, Håkan; Walldius, Gøran; Grill, Valdemar Erik Robert; Jungner, Ingmar; Gudbjörnsdottir, Sofia; Hammar, Niklas (Journal article; Peer reviewed, 2014)Context: Fructosamine is a glycemic biomarker which may be useful for indication and control of diabetes respectively. Objective: The objective of the study was to evaluate fructosamine as an indicator of ... -
Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates
Hals, Ingrid Kathrin; Ohki, Tsuyoshi; Singh, Rinku; Ma, Zuheng; Björklund, Anneli; Balasuriya, Chandima Nirupa Dilruks; Scholz, Hanne; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)We previously showed that hyperoxia in vitro negatively affects beta cells of the rat. Here, we tested for possible clinical significance as well as mitochondrial interactions by hyperoxia, using human islets (function and ... -
Impact of a FTO gene risk variant on variables of energy metabolism in adults with obesity class 2 and 3
De Soysa, Ann Kristin Hjelle; Klevjer, Marie; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Journal article; Peer reviewed, 2019)Purpose The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity per se. Against this background, we investigated the impact of FTO allele ... -
Interaction between overweight and genotypes of HLA, TCF7L2, and FTO in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes
Hjort, Rebecka; Löfvenborg, Josefin E.; Ahlqvist, Emma; Alfredsson, Lars; Andersson, Tomas; Grill, Valdemar Erik Robert; Groop, Leif; Sørgjerd, Elin Pettersen; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2019)Objective We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
Hals, Ingrid Kathrin; Fleiner, Hanne Fiskvik; Reimers, Nina; Astor, Marianne; Filipsson, Karin; Ma, Zuheng; Grill, Valdemar Erik Robert; Björklund, Anneli (Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D
Björklund, Anneli; Hals, Ingrid Kathrin; Grill, Valdemar Erik Robert; Ludvigsson, Johnny (Peer reviewed; Journal article, 2022)Background: Latent Autoimmune Diabetes in Adults (LADA) constitutes around 10% of all diabetes. Many LADA patients gradually lose their insulin secretion and progress to insulin dependency. In a recent trial BALAD (Behandling ... -
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
Hals, Ingrid Katrin; Bruerberg, Simon Gustafson; Ma, Zuheng; Scholz, Hanne; Björklund, Anneli; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2015)Objective: To provide novel insights on mitochondrial respiration in β-cells and the adaptive effects of hypoxia. Methods and Design Insulin-producing INS-1 832/13 cells were exposed to 18 hours of hypoxia followed by ... -
NEFA Dynamics in Adults With Severe Obesity and Insulin Resistance: No Coupling to the rs9939609 FTO Risk Allele
Mostad, Ingrid Løvold; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2023)Context: The FTO gene is highly expressed in adipose tissues; however, whether nonesterified fatty acids (NEFA) dynamics are impacted by FTO has not been rigorously tested for in a uniformly obese study population comprising ... -
Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study
Hjort, Rebecka; Ahlqvist, Emma; Carlsson, Per-Ola; Grill, Valdemar Erik Robert; Groop, Leif; Martinell, Mats; Rasouli, Bahareh; Rosengren, Anders; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Journal article; Peer reviewed, 2018)Aims/hypothesis Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation ... -
Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
Hjort, Rebecka; Ahlqvist, Emma; Andersson, Tomas; Alfredsson, Lars; Carlsson, Per-Ola; Grill, Valdemar Erik Robert; Groop, Leif; Martinell, Mats; Sørgjerd, Elin Pettersen; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2020)Purpose Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune ... -
Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study
Sørgjerd, Elin Pettersen; Thorsby, Per Medbøe; Torjesen, Peter A; Skorpen, Frank; Kvaløy, Kirsti; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2015)Background It is well known that anti-GAD (glutamic acid decarboxylase) serves as a marker for development of autoimmune diabetes in adults. On the other hand, the clinical implications of anti-GAD positivity in persistently ... -
Small RNAs are differentially expressed in autoimmune and non-autoimmune diabetes and controls
Sørgjerd, Elin Pettersen; Mjelle, Robin; Beisvag, Vidar; Flatberg, Arnar; Grill, Valdemar Erik Robert; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2022)Objective Diabetes is a heterogeneous disease and a precise diagnosis of diabetes subgroups is necessary to initiate proper early treatment and clinical management of the disease. Circulating small RNAs (sRNAs) are ... -
Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults
Edstorp, Jessica; Wei, Yuxia; Ahlqvist, Emma; Alfredsson, Lars; Grill, Valdemar Erik Robert; Groop, Leif; Rasouli, Bahareh; Sørgjerd, Elin Pettersen; Thorsby, Per Medbøe; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2022)Aims/hypotheses Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults ... -
The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and negative subjects: A post-hoc analysis of the ORIGIN trial
Birkeland, Kåre I.; Grill, Valdemar Erik Robert; Wium, Cecilie; McQueen, Matthew J.; López-Jaramillo, Patricio; Lee, Shun Fu; Gerstein, Hertzel C. (Journal article; Peer reviewed, 2018)We compared cardiovascular and other outcomes in patients with dysglycaemia with or without anti‐glutamic acid dehydrogenase (GAD) antibodies participating in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) ... -
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL-1ra and IL-1 beta is associated with progressive disease
Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)Background Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ... -
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease
Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)Background - Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ...