Blar i NTNU Open på forfatter "Selbæk, Geir"

Viser treff 41-60 av 101

    • A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease 

      Wightman, Douglas P.; Jansen, Iris E.; Savage, Jeanne E.; Shadrin, Alexey; Bahrami, Shahram; Holland, Dominic; Rongve, Arvid; Børte, Sigrid; Winsvold, Bendik K S; Drange, Ole Kristian; Martinsen, Amy E.; Skogholt, Anne Heidi; Willer, Cristen; Bråthen, Geir; Bosnes, Ingunn; Nielsen, Jonas Bille; Fritsche, Lars; Thomas, Laurent; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Johnsen, Marianne Bakke; Meisingset, Tore Wergeland; Zhou, Wei; Proitsi, Petroula; Hodges, Angela; Dobson, Richard; Velayudhan, Latha; Sealock, Julia; Davis, Lea K.; Pedersen, Nancy L.; Reynolds, Chandra A.; Karlsson, Ida K.; Magnusson, Sigurdur; Stefansson, Hreinn; Thordardottir, Steinunn; Jónsson, Pálmi V.; Snædal, Jon; Zettergren, Anna; Skoog, Ingmar; Kern, Silke; Waern, Margda; Zetterberg, Henrik; Blennow, Kaj; Stordal, Eystein; Hveem, Kristian; Zwart, John Anker Henrik; Athanasiu, Lavinia; Selnes, Per; Saltvedt, Ingvild; Sando, Sigrid Botne; Ulstein, Ingun; Djurovic, Srdjan; Fladby, Tormod; Aarsland, Dag; Selbæk, Geir; Ripke, Stephan; Stefánsson, Kári; Andreassen, Ole; Posthuma, Danielle (Journal article; Peer reviewed, 2021)
      Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. ...

    • Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers 

      Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Athanasiu, Lavinia; Bahrami, Shahram; Bergh, Sverre; Djurovic, Srdjan; Fladby, Tormod; Jarholm, Jonas Alexander; Knapskog, Anne Brita; Pålhaugen, Lene; Saltvedt, Ingvild; Selbæk, Geir; Selnes, Per; Andreassen, Ole; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tsolaki, Magda; Van Broeckhoven, Christine; Van Dongen, Jasper; van Swieten, John C.; Vandenberghe, Rik; Vidal, Jean-Sébastien; Visser, Pieter J.; Vogelgsang, Jonathan; Waern, Margda; Wagner, Michael; Wiltfang, Jens; Wittens, Mandy M.J.; Zetterberg, Henrik; Zulaica, Miren; van Duijn, Cornelia M.; Bjerke, Maria; Engelborghs, Sebastiaan; Jessen, Frank; Teunissen, Charlotte E.; Pastor, Pau; Hiltunen, Mikko; Ingelsson, Martin; Clarimón, Jordi; Sleegers, Kristel; Ruiz, Agustín; Ramirez, Alfredo; Cruchaga, Carlos; Lambert, Jean-Charles; van der Flier, Wiesje M. (Peer reviewed; Journal article, 2022)
      Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ...

    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...

    • Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty 

      Kirkhus, Lene; Saltyte Benth, Jurate; Kristjansson, Siri Rostoft; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Harneshaug, Magnus; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2017)
      Background: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ...

    • Health-related quality of life in older depressed psychogeriatric patients: one year follow-up 

      Helvik, Anne-Sofie; Corazzini, Kirsten; Selbæk, Geir; Björklöf, Guro Hanevold; Laks, Jerson; Saltyte Benth, Jurate; Østbye, Truls; Engedal, Knut (Peer reviewed; Journal article, 2016)
      Background Knowledge about long-term change in health related quality of life (HQoL) among older adults after hospitalization for treatment of depression has clinical relevance. The aim was firstly to describe the change ...

    • Hearing impairment and risk of dementia in The HUNT Study (HUNT4 70+): a Norwegian cohort study 

      Myrstad, Christian; Engdahl, Bo Lars; Costafreda, Sergi G.; Krokstad, Steinar; Lin, Frank; Livingston, Gill; Strand, Bjørn Heine; Øhre, Beate; Selbæk, Geir (Peer reviewed; Journal article, 2023)
      Hearing impairment is strongly associated with future dementia. No studies have reported objectively measured hearing impairment in a cohort with a long period of follow-up (>20 years), and few have reported follow-up over ...

    • A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease 

      Edwin, Trine Holt; Henjum, Kristi; Nilsson, Lars N. G.; Watne, Leiv; Persson, Karin Ester Torun; Eldholm, Rannveig Sakshaug; Saltvedt, Ingvild; Halaas, Nathalie Bodd; Selbæk, Geir; Engedal, Knut; Strand, Bjørn Heine; Knapskog, Anne Brita (Peer reviewed; Journal article, 2020)
      Introduction: The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity. We explored if cerebrospinal fluid (CSF) soluble TREM2 ...

    • The Human Brain Representation of Odor Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Dementia of Mild Degree 

      Kjelvik, Grete; Evensmoen, Hallvard Røe; Hummel, Thomas; Engedal, Knut; Selbæk, Geir; Saltvedt, Ingvild; Håberg, Asta (Peer reviewed; Journal article, 2020)
      Background: Odor identification (OI) ability is a suggested early biomarker of Alzheimer’s disease. In this study, we investigated brain activity within the brain’s olfactory network associated with OI in patients with ...

    • Impacts of COVID-19 restrictions on level of physical activity and health in home-dwelling older adults in Norway 

      Nygård, Arnhild Jenssen; Taraldsen, Kristin; Granbo, Randi; Selbæk, Geir; Helbostad, Jorunn L. (Journal article; Peer reviewed, 2022)

    • Insomnia and risk of dementia in a large population-based study with 11-year follow-up: The HUNT study 

      Selbæk-Tungevåg, Selma; Selbæk, Geir; Strand, Bjørn Heine; Myrstad, Christian; Livingston, Gill; Lydersen, Stian; Bergh, Sverre; Ernstsen, Linda (Peer reviewed; Journal article, 2023)
      Despite evidence suggesting that insomnia is associated with the risk of dementia and cognitive dysfunction, studies have shown mixed results. Dementia has a long prodromal phase, and studies with long follow-up are required ...

    • Leisure-Time Physical Activity Is Associated With Reduced Risk of Dementia-Related Mortality in Adults With and Without Psychological Distress: The Cohort of Norway 

      Zotcheva, Ekaterina; Selbæk, Geir; Bjertness, Espen; Ernstsen, Linda; Strand, Bjørn Heine (Journal article; Peer reviewed, 2018)
      Background: Leisure-time physical activity (PA) has been proposed as a protective factor against dementia, whereas psychological distress is associated with an increased risk of dementia. We investigated the associations ...

    • Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in Norway 

      Skirbekk, Vegard Fykse; Bowen, Catherine E; Håberg, Asta; Jugessur, Astanand; Engdahl, Bo Lars; Bratsberg, Bernt Magne; Zotcheva, Ekaterina; Selbæk, Geir; Kohler, Hans-Peter; Weiss, Jordan; Harris, Jennifer Ruth; Tom, Sarah; Krokstad, Steinar; Stern, Yaakov; Strand, Bjørn Heine (Peer reviewed; Journal article, 2022)
      Objectives: Earlier studies suggest that being married in later life protects against dementia, and that being single in old age increases the risk of dementia. In this study, we examine midlife marital status trajectories ...

    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...

    • Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study 

      Zotcheva, Ekaterina; Bergh, Sverre; Selbæk, Geir; Krokstad, Steinar; Håberg, Asta; Strand, Bjørn Heine; Ernstsen, Linda (Journal article; Peer reviewed, 2018)
      Background: Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk. Objective: We investigated independent and joint ...

    • Mobility and cognition at admission to the nursing home – a cross-sectional study 

      Sverdrup, Karen; Bergh, Sverre; Selbæk, Geir; Røen, Irene Mari; Kirkevold, Øyvind; Tangen, Gro Gujord (Journal article; Peer reviewed, 2018)
      Background Earlier studies show that the main reasons for admission to long-term nursing home care are cognitive impairment and functional impairments of activities of daily life. However, descriptive evidence of mobility ...

    • Modifiable factors affecting older patients' quality of life and physical function during cancer treatment 

      Kirkhus, Lene; Harneshaug, Magnus; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Bergh, Sverre; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Kirkevold, Øyvind; Borza, Tom; Saltvedt, Ingvild; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)
      Background Maintaining physical function and quality of life (QoL) are prioritized outcomes among older adults. We aimed to identify potentially modifiable factors affecting older patients' physical function and QoL ...

    • Mortality in older adults with frequent alcohol consumption and use of drugs with addiction potential – The Nord Trøndelag Health Study 2006-2008 (HUNT3), Norway, a population-based study 

      Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)
      Background The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential ...

    • MRI-assessed atrophy subtypes in Alzheimer’s disease and the cognitive reserve hypothesis 

      Persson, Karin; Eldholm, Rannveig Sakshaug; Barca, Maria Lage; Cavallin, Lena; Ferreira, Daniel; Knapskog, Anne Brita; Selbæk, Geir; Brækhus, Anne; Saltvedt, Ingvild; Westman, Eric; Engedal, Knut (Journal article; Peer reviewed, 2017)
      Background/Aims MRI assessment of the brain has demonstrated four different patterns of atrophy in patients with Alzheimer’s disease dementia (AD): typical AD, limbic-predominant AD, hippocampal-sparing AD, and a subtype ...

    • MRI-based classification models in prediction of mild cognitive impairment and dementia in late-life depression 

      Lebedeva, Aleksandra K.; Westman, Eric; Borza, Tom; Beyer, Mona K.; Engedal, Knut; Aarsland, Dag; Selbæk, Geir; Håberg, Asta (Journal article; Peer reviewed, 2017)
      Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to ...

    • Multi-psychotropic drug prescription and the association to neuropsychiatric symptoms in three Norwegian nursing home cohorts between 2004 and 2011 

      Gulla, Christine; Selbæk, Geir; Flo, Elisabeth; Kjome, Reidun Lisbet Skeide; Kirkevold, Øyvind; Husebø, Bettina (Journal article; Peer reviewed, 2016)
      Background Neuropsychiatric symptoms, such as affective symptoms, psychosis, agitation, and apathy are common among nursing home patients with and without dementia. Treatment with one or more psychotropic drug is often ...