Blar i NTNU Open på forfatter "Røsand, Øystein"
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Cardiac exosomes in ischemic heart disease—A narrative review
Røsand, Øystein; Høydal, Morten (Peer reviewed; Journal article, 2021)Ischemic heart disease (IHD) is the primary cause of death globally. IHD is associated with the disruption of blood supply to the heart muscles, which often results in myocardial infarction (MI) that further may progress ... -
Characterization of new mouse model lacking DNA repair factor MRI
Røsand, Øystein (Master thesis, 2019)Double-strand breaks (DSBs) are constantly generated in the DNA by endogenous and exogenous agents. In mammalian cells, DSBs activate DNA damage responses (DDRs) to repair the lesions. One major DSB repair pathway is ... -
Effects of doxorubicin on cell death and the transcriptome in human AC16 cardiomyocytes
Lunde, Ingvild (Master thesis, 2022)Bakgrunn: Kreft og hjarte- og karsjukdom er leiande dødsårsaker i verda. Doxorubicin er mykje nytta som cellegift i kreftbehandling, men utvikling av kardiotoksisitet avgrensar bruken. Faktorar som bidreg til doxorubicin-indusert ... -
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
Castaneda Zegarra, Sergio Miguel; Huse, Camilla; Røsand, Øystein; Sarno, Antonio; Xing, Mengtan; Zhang, Qindong; Alirezaylavasani, Amin; Werner, Julia; Ji, Ping; Liabakk, Nina-Beate; Wang, Wei; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)Classical non-homologous end joining (NHEJ) is a molecular pathway that detects, processes, and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. Mutations in several NHEJ genes result in neurological ... -
GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
Marwarha, Gurdeep; Røsand, Øystein; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2022)Apoptotic cell death is a deleterious consequence of hypoxia-induced cellular stress. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxia stress. We have ... -
miR-210 Regulates Apoptotic Cell Death during Cellular Hypoxia and Reoxygenation in a Diametrically Opposite Manner
Marwarha, Gurdeep; Røsand, Øystein; Scrimgeour, Nathan Robert; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2021)Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic ... -
Overexpression of neuron-derived orphan receptor 1 (NOR-1) rescues cardiomyocytes from cell death and improves viability after doxorubicin induced stress
Berg, Per-Christian; Hansson, Åse Mari Larsen; Røsand, Øystein; Marwarha, Gurdeep; Høydal, Morten (Peer reviewed; Journal article, 2021)Following myocardial infarction, reperfusion injury (RI) is commonly observed due to the excessive formation of, e.g., reactive oxygen species (ROS). Doxorubicin (DOX), a widely used anti-cancer drug, is also known to cause ...