Browsing NTNU Open by Author "Hwang, Liang-Dar"
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A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)
D'Urso, Shannon; Wang, Geng; Hwang, Liang-Dar; Moen, Gunn-Helen; Warrington, Nicole Maree; Evans, David M. (Journal article; Peer reviewed, 2020)Recent studies have used Mendelian randomization (MR) to investigate the observational association between low birth weight (BW) and increased risk of cardiometabolic outcomes, specifically cardiovascular disease, glycemic ... -
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
Warrington, Nicole Maree; Hwang, Liang-Dar; Nivard, Michel G.; Evans, David M. (Peer reviewed; Journal article, 2021)Estimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. We compare several multivariate methods that utilize summary results statistics from ... -
Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs
Hwang, Liang-Dar; Tubbs, Justin D.; Luong, Justin; Lundberg, Mischa; Moen, Gunn-Helen; Wang, Geng; Warrington, Nicole Maree; Sham, Pak C.; Cuellar-Partida, Gabriel; Evans, David M. (Peer reviewed; Journal article, 2020)Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the transmission of genes from parents to their children. However, given ... -
Intrauterine Growth and Offspring Neurodevelopmental Traits A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa)
D'Urso, Shannon; Moen, Gunn-Helen Øiseth; Hwang, Liang-Dar; Hannigan, Laurie John; Corfield, Elizabeth Claire; Ask, Helga; Johannson, Stefan; Njølstad, Pål Rasmus; Beaumont, Robin N.; Freathy, Rachel M.; Evens, David M.; Havdahl, Alexandra (Journal article; Peer reviewed, 2023)Importance Conventional epidemiological analyses have suggested that lower birth weight is associated with later neurodevelopmental difficulties; however, it is unclear whether this association is causal. Objective ... -
Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health
Wang, Geng; Bhatta, Laxmi; Moen, Gunn-Helen; Hwang, Liang-Dar; Kemp, John P.; Bond, Tom A.; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M.; Warrington, Nicole M. (Peer reviewed; Journal article, 2021)Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether ... -
Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk
D’Urso, Shannon; Arumugam, Pooja; Weider, Therese; Hwang, Liang-Dar; Bond, Tom A.; Kemp, John P.; Warrington, Nicole Maree; Evans, David M.; O’Mara, Tracy A.; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2022)Background Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships ... -
Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth
Brito Nunes, Caroline; Huang, Peiyuan; Wang, Geng; Lundberg, Mischa; D'Urso, Shannon; Wootton, Robyn E; Borges, Maria Carolina; Lawlor, Deborah A.; Warrington, Nicole Maree; Evans, David M.; Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2023)Background Coffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee ... -
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes
Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth; Evans, David M. (Peer reviewed; Journal article, 2022)Maternal genetic effects can be defined as the effect of a mother’s genotype on the phenotype of her offspring, independent of the offspring’s genotype. Maternal genetic effects can act via the intrauterine environment ...