Browsing NTNU Open by Author "Høgset, Anders"
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Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization
Baglo, Yan; Hagen, Lars; Høgset, Anders; Drabløs, Finn; Otterlei, Marit; Gederaas, Odrun Arna (Journal article; Peer reviewed, 2014)Bleomycin is a cytotoxic chemotherapeutic agent widely used in cancer treatment. However, its efficacy in different cancers is low, possibly due to limited cellular internalization. In this study, a novel approach known ... -
Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination
Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind (Journal article; Peer reviewed, 2018)Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer vaccination. This requires cytosolic antigens that feed into the MHC class ... -
Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells
Gederaas, Odrun Arna; Sharma, Animesh; Mbarak, Saide; Sporsheim, Bjørnar; Høgset, Anders; Bogoeva, Vanya; Slupphaug, Geir; Hagen, Lars (Peer reviewed; Journal article, 2023)Photochemical internalization (PCI) is a promising new technology for site-specific drug delivery, developed from photodynamic therapy (PDT). In PCI, light-induced activation of a photosensitizer trapped inside endosomes ... -
Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells
Gederaas, Odrun Arna; Sørensen, Andreas S.; Lindgren, Mikael; Melø, Thor Bernt; Altin, Dag; Flatby, Ellen M. Samdahl; Høgset, Anders; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Glioblastoma multiforme is one of the most aggressive cancer forms in humans, and has low recovery rates after surgery, ionizing radiation and chemotherapy. Therefore, there is a high interest in the development of new ...