• Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...
    • Method for Designing Semantic Annotation of Sepsis Signs in Clinical Text 

      Yan, Melissa Y.; Gustad, Lise Tuset; Høvik, Lise Husby; Nytrø, Øystein (Chapter, 2023)
      Annotated clinical text corpora are essential for machine learning studies that model and predict care processes and disease progression. However, few studies describe the necessary experimental design of the annotation ...
    • Nurses' and Physicians' Experiences After Implementation of a Quality Improvement Project to Improve Sepsis Awareness in Hospitals 

      Gustad, Lise Tuset; Bangstad, Inger-Lise; Torsvik, Malvin Arnold; Rise, Marit By (Peer reviewed; Journal article, 2024)
      Purpose: Previous research has explored nurses´ experience with the implementation of early detection alert systems, and nurses and physicians’ perceptions of sepsis management and use of sepsis triage. As one of the first, ...
    • Predicting In-Hospital Death from Derived EHR Trajectory Features 

      Bopche, Rajeev; Gustad, Lise Tuset; Afset, Jan Egil; Damås, Jan Kristian; Nytrø, Øystein (Chapter, 2024)
      Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ...
    • Predicting in-hospital death from derived EHR trajectory features 

      Bopche, Rajeev; Gustad, Lise Tuset; Afset, Jan Egil; Damås, Jan Kristian; Nytrø, Øystein (Chapter, 2023)
      Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ...
    • Preliminary Processing and Analysis of an Adverse Event Dataset for Detecting Sepsis-Related Events 

      Yan, Melissa; Høvik, Lise Husby; Pedersen, André; Gustad, Lise Tuset; Nytrø, Øystein (Chapter, 2021)
      Adverse event (AE) reports contain notes detailing procedural and guideline deviations, and unwanted incidents that can bring harm to patients. Available datasets mainly focus on vigilance or post-market surveillance of ...
    • Quality of care for peripheral intravenous catheters (PIVCs) in Nepal: A cross-sectional study on feasibility and inter-rater agreement of the Peripheral Intravenous Catheters-mini Questionnaire (PIVC-miniQ) in a tertiary care hospital 

      Shrestha, Sulekha; Vieler, Johannes; Haug, Nikolai Juliussen; Afset, Jan Egil; Høvik, Lise Husby; Lydersen, Stian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2021)
      Objectives There is a lack of data regarding the quality of peripheral intravenous catheter (PIVC)-related care from low-income and middle-income countries, even though the use of PIVCs may lead to local or severe systemic ...
    • Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study 

      Skei, Nina Vibeche; Moe, Karoline; Nilsen, Tom Ivar Lund; Aasdahl, Lene; Prescott, Hallie C.; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2023)
      Background Sepsis survivors commonly experience functional impairment, which may limit return to work. We investigated return to work (RTW) of patients hospitalized with sepsis and the associations with patient and ...
    • SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells 

      Hammer, Quirin; Dunst, Josefine; Christ, Wanda; Picarazzi, Francesca; Wendorff, Mareike; Momayyezi, Pouria; Huhn, Oisín; Netskar, Herman Krogstad; Maleki, Kimia T.; García, Marina; Sekine, Takuya; Sohlberg, Ebba; Azzimato, Valerio; Aouadi, Myriam; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Hov, Johannes Espolin Roksund; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Vadla, May Sissel; Lenning, Ole Bernt; Myhre, Ronny; Haider, Sammra; Dudman, Susanne Gjeruldsen; Karlsen, Tom Hemming; Folseraas, Trine; Skogen, Vegard; Degenhardt, Frauke; Franke, Andre; Spallotta, Francesco; Mori, Mattia; Michaëlsson, Jakob; Björkström, Niklas K.; Rückert, Timo; Romagnani, Chiara; Horowitz, Amir; Klingström, Jonas; Ljunggren, Hans-Gustaf; Malmberg, Karl-Johan (Peer reviewed; Journal article, 2022)
      Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in ...
    • Sepsis prediction, early detection, and identification using clinical text for machine learning: a systematic review 

      Yan, Melissa Y.; Gustad, Lise Tuset; Nytrø, Øystein (Peer reviewed; Journal article, 2021-12-13)
      Objective To determine the effects of using unstructured clinical text in machine learning (ML) for prediction, early detection, and identification of sepsis. Materials and methods PubMed, Scopus, ACM DL, dblp, and ...
    • Sepsistilsyn og kvalitetsforbedringsarbeid på akuttmottaket ved Sykehuset Levanger: Variasjon i trender - antibiotikabruk, antall blodkulturer og resistensutvikling 

      Olsen, Melliane Muteba (Master thesis, 2020)
      Bakgrunn: Sepsis er en alvorlig infeksjon som forårsaker 12% av alle dødsfall i norske sykehus. Sepsis skyldes at mikroorganismer kommer over i blodbanen og utløser en overdreven immunreaksjon. Dette kan gi organsvikt. ...
    • Symptoms of anxiety and depression and risk of acute myocardial infarction: the HUNT 2 study 

      Gustad, Lise Tuset; Laugsand, Lars Erik; Janszky, Imre; Dalen, Håvard; Bjerkeset, Ottar (Journal article; Peer reviewed, 2014)
      Aims The nature of the association of depression and anxiety with risk for acute myocardial infarction (AMI) remains unclear. We aimed to study the prospective association of single and recurrent self-reported symptoms of ...
    • Symptoms of anxiety and depression and risk of heart failure: The HUNT Study 

      Gustad, Lise Tuset; Laugsand, Lars Erik; Janszky, Imre; Dalen, Håvard; Bjerkeset, Ottar (Journal article; Peer reviewed, 2014)
      Aims The nature of the association of depression and anxiety with risk for acute myocardial infarction (AMI) remains unclear. We aimed to study the prospective association of single and recurrent self-reported symptoms of ...
    • Terminology and ontology development for semantic annotation: A use case on sepsis and adverse events 

      Yan, Melissa Yuting; Gustad, Lise Tuset; Høvik, Lise Husby; Nytrø, Øystein (Peer reviewed; Journal article, 2023)
      Annotations enrich text corpora and provide necessary labels for natural language processing studies. To reason and infer underlying implicit knowledge captured by labels, an ontology is needed to provide a semantically ...
    • The effects of shift work on the immune system: A narrative review 

      Thorkildsen, Marianne Stenbekk (Master thesis, 2022)
      Norsk sammendrag Introduksjon: Skiftarbeid påvirker trolig helsen negativt og en av hypotesene er at skiftarbeid påvirker immunforsvaret og fører til økt risiko for infeksjon. Tidligere litterære sammendrag har konkludert ...
    • Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021 

      Skei, Nina Vibeche; Nilsen, Tom Ivar Lund; Mohus, Randi Marie; Prescott, Hallie C.; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2023)
      Background Few studies have reported on mortality beyond one year after sepsis. We aim to describe trends in short- and long-term mortality among patients admitted with sepsis, and to describe the association between ...
    • Understanding and Reasoning About Early Signs of Sepsis - From Annotation Guideline to Ontology 

      Yan, Melissa Y.; Høvik, Lise Husby; Gustad, Lise Tuset; Nytrø, Øystein (Chapter, 2022)
      In the clinical domain, patient states such as sepsis due to bloodstream infection (BSI) result in observable symptoms and signs used to determine diagnosis and treatment, all of which often is documented in electronic ...
    • Use of Peripheral Intravenous Catheters at Dhulikhel Hospital, Nepal 

      Haug, Nikolai Juliussen; Vieler, Johannes (Master thesis, 2020)
      Sammendrag Bakgrunn og mål: Perifere intravenøse venekateter (PIVK) er hyppig brukt på verdensbasis og opptil 80% av pasienter innlagt på sykehus har en PIVK inneliggende. PIVKer er assosiert med komplikasjoner, for ...
    • Use of peripheral venous catheters in two Norwegian hospitals. 

      Høvik, Lise Husby; Gjeilo, Kari Hanne; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2020)
      BAKGRUNN De fleste pasienter ved norske sykehus får rutinemessig ett eller flere perifere venekatetre. Et perifert venekateter regnes som ufarlig, men kan gi lokal infeksjon, med blodstrømsinfeksjon og sepsis som følge. ...